A5100730126- Spaceflight effects on biology
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Trace Elements in Health
- Bone health and osteoporosis research
- Ovarian cancer diagnosis and treatment
- Electromagnetic Fields and Biological Effects
- Immunotherapy and Immune Responses
- Bone Metabolism and Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Drug Transport and Resistance Mechanisms
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
- Cell Adhesion Molecules Research
- Medical and Biological Ozone Research
- Chronic Lymphocytic Leukemia Research
- Climate variability and models
- Body Composition Measurement Techniques
Zhuhai People's Hospital
2024-2025
Beijing Institute of Technology
2025
Jinan University
2024-2025
Zhuhai Institute of Advanced Technology
2025
Henan University of Science and Technology
2025
People's Hospital of Bishan District
2025
Anhui and Huaihe River Institute of Hydraulic Research
2024
Beijing Tongren Hospital
2024
Capital Medical University
2024
Shanghai University of Traditional Chinese Medicine
2023-2024
Background and Aims Tumor metastasis is a major factor of high recurrence mortality in hepatocellular carcinoma (HCC), but its underlying mechanism remains elusive. We report that PDZ LIM domain protein 1 (PDLIM1) significantly down‐regulated metastatic human HCC tissues, which predicts unfavorable prognosis, suggesting PDLIM1 may play an important inhibitory role during metastasis. Approach Results Functional studies indicate knockdown induces epithelial‐to‐mesenchymal transition (EMT)...
Many studies have indicated that static magnetic fields (SMFs) positive effects on bone tissue, including formation and healing process. Evaluating the of SMFs cell (especially osteoblast) function exploring mechanism, which is critical for understanding possible risks or benefits from to balance remodeling. Iron natural relationship, iron an essential element normal metabolism. overload deficiency can cause severe disorders osteoporosis. However, there are few reports regarding role in...
The detection of HLA-G expression might serve as a clinical marker in the diagnosis or prediction outcomes for certain types carcinoma. aim this study was to determine whether has any important applications patients with esophageal squamous cell carcinoma (ESCC) by using immunohistochemical methods. We observed that protein expressed 90.9% (110/121) primary sites ESCC but not normal tissues. tumors significantly correlated histologic grade, depth invasion, nodal status, host immune response,...
Abstract Background The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but colorectal carcinoma (CRC) remains be established. purpose this study was investigate expression pattern significance CRC progression. Method 265 specimens 129 matched adjacent normal mucosa were collected. Expression clinical samples examined by immunostaining. effect on cell proliferation measured MTT assay,...
Objective Although Polymerase-epsilon (POLE)-mutated and mismatch repair (MMR)-deficient endometrial cancers (ECs) are considered as promising candidates for anti-PD-1/PD-L1 therapy, selecting only these patients may exclude other who could potentially respond to this treatment strategy, highlighting the need of additional biomarkers better patient selection. This study aims evaluate potential predictive therapy in addition POLE mutation (POLEm) MMR deficiency (MMRd). Methods We performed...
G-protein-coupled receptor 48 (GPR48) is an orphan belonging to the receptors family, which plays important role in development of various organs and cancer progression such as gastric colorectal (CRC). However, prognostic value GPR48 expression patients with CRC has not been reported. In this study, we observed that was overexpressed primary metastatic lymph nodes closely correlated tumor invasion metastasis. Multivariate analysis indicated high a poor factor for overall survival patients....
Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies. found be expressed a variety of malignant tumors. In this study, we investigated the histologic colorectal or breast cancers, as well relationship between and proteinuria cancers. A total 101 enrolled 81 them had cancer 20 cancer. detected by immunohistochemical staining tumor tissues....
Angiogenesis is a crucial process in tumorigenesis and development. The role of exosomes derived from hepatocellular carcinoma (HCC) cells angiogenesis has not been clearly elucidated.Exosomes were isolated HCC cell lines (HCCLM3, MHCC97L, PLC/RFP/5) by ultracentrifugation identified nano transmission electron microscopy (TEM), NanoSight analysis western blotting, respectively. In vitro vivo analyses showed that highly metastatic enhanced the migration, invasion tube formation human...
Live streaming, as an emerging e-commerce model, has changed the traditional shopping experience and business model. However, due to high slot commission fees, many brands have refused celebrities for sales instead invested more marketing effort in official live streaming channel, such advertising or inviting room. This paper focuses on impact of brand's invite room promotional purposes channel selection strategy. An interesting finding this is that can change celebrity's charisma rate...