A5101768903- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- COVID-19 epidemiological studies
- MicroRNA in disease regulation
- Lymphatic System and Diseases
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Evaluation Methods in Various Fields
- Inflammatory mediators and NSAID effects
- Cancer Research and Treatments
- Environmental Quality and Pollution
- RNA modifications and cancer
- EEG and Brain-Computer Interfaces
- Gut microbiota and health
- Histone Deacetylase Inhibitors Research
- Infection Control and Ventilation
- Cancer Mechanisms and Therapy
- Innovations in Concrete and Construction Materials
- High Altitude and Hypoxia
- Functional Brain Connectivity Studies
- SARS-CoV-2 and COVID-19 Research
- Breast Cancer Treatment Studies
Tianjin Hospital
2014-2025
Tianjin University
2024-2025
Zhuhai People's Hospital
2025
Jinan University
2025
Jiangsu Cancer Hospital
2020-2024
Nanjing Medical University
2009-2024
Ruian People's Hospital
2017-2024
Wenzhou Medical University
2017-2024
Tianjin Huanhu Hospital
2024
Xiamen University of Technology
2022-2024
Peroxisome proliferator–activated receptor–δ (PPARD) is upregulated in many major human cancers, but the role that its expression cancer cells has metastasis remains poorly understood. Here, we show specific PPARD downregulation or genetic deletion of significantly repressed various models vivo. Mechanistically, promoted angiogenesis via interleukin 8 vivo and vitro. Analysis transcriptome profiling HCT116 colon with without gene patterns The Cancer Genome Atlas colorectal adenocarcinoma...
Transfer RNA-derived RNA fragments (tRFs) belong to non-coding RNAs (ncRNAs) discovered in most carcinomas. Although some articles have demonstrated the characteristics of tRFs gastric carcinoma (GC), underlying mechanisms still need be elucidated. Meanwhile, it was reported that MAPK pathway momentous GC progression. Thus we focused on investigating whether tRF-Glu-TTC-027 could act as a key role progression with regulation pathway. We collected data tRNA-derived expression profile from six...
Abstract Background As a new kind of non-coding RNAs (ncRNAs), tRNA derivatives play an important role in gastric carcinoma (GC). Nevertheless, the underlying mechanism were involved was rarely illustrated. Methods We screened out derivative, tRF-Val-CAC-016, based on tsRNA sequencing and demonstrated effect tRF-Val-CAC-016 exerted GC proliferation vitro vivo. applied Dual-luciferase reporter assay, RIP bioinformatic analysis to discover downstream target tRF-Val-CAC-016. Then CACNA1d...
Abstract APC mutations activate aberrant β-catenin signaling to drive initiation of colorectal cancer; however, cancer progression requires additional molecular mechanisms. PPAR-delta (PPARD), a downstream target β-catenin, is upregulated in cancer. However, promotion intestinal tumorigenesis following deletion PPARD Apcmin mice has raised questions about the effects on activation and In this study, we used mouse models overexpression or combined with mutation (ApcΔ580) epithelial cells...
The incidence and clinical features of portopulmonary hypertension (POPH) have not been adequately described it is currently unknown whether an association exists between the severity POPH liver function. Additionally, risk factors are yet to be identified. aim this study was determine prevalence, describe investigate potential POPH. We conducted a 100 cirrhotic patients hospitalized March 2011 May 2012 at Tongji Hospital in Shanghai. characteristics with without were analyzed. Clinical...
Abstract Long non-coding RNAs (lncRNA) have been identified as key regulators of tumorigenesis and development. We aim to explore the biological functions molecular mechanisms lncRNA MIR200CHG in breast cancer. found that is highly expressed cancer tissues related tumor size histopathological grade. In vitro vivo experiments confirmed can promote proliferation, invasion, drug resistance. directly binds transcription factor Y-box binding protein-1 (YB-1), inhibits its ubiquitination...
Supernumerary robotic finger (SRF) has shown unique advantages in the field of motor augmentation and rehabilitation, while development brain computer interface (BCI) technology provided possibility for direct control SRF. However, neuroplasticity effects BCI-actuated SRF (BCI-SRF) training based on "six finger" imagery paradigm are still unclear. This study recruited 20 healthy right-handed participants randomly assigned them to either a BCI-SRF group or sham group. During testing phase...
Background: Vascular endothelial growth factor (VEGF) is highly expressed in many types of tumors, including pancreatic cancer. Tumor cellderived VEGF promotes angiogenesis and tumor progression. However, the role glucose metabolism remains unclear. Objective: We investigated underlying mechanism cancer cells. Method: Pancreatic cells were stimulated with VEGF165 for 1 or 2 h. The oxygen consumption rates (OCR) extracellular acidification (ECAR) measured using Seahorse XF96 Extracellular...
Abstract Background Peroxisome proliferator-activated receptor delta (PPARδ) promotes inflammation and carcinogenesis in many organs, but the underlying mechanisms remains elusive. In stomachs, PPARδ significantly increases chemokine Ccl20 expression gastric epithelial cells while inducing adenocarcinoma (GAC). CCR6 is sole of CCL20. Here, we examine role PPARδ–mediated Ccl20/Ccr6 signaling GAC investigate mechanisms. Methods The effects inhibition by its specific antagonist GSK3787 on were...
The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 dependence. In non-small cell lung cancer (NSCLC), these mutations are associated enhanced sensitivity to inhibitors vitro clinical response vivo. Although less prevalent, insertions exon 20 have also been described NSCLC. These mutations, however, resistance inhibitors. NSCLC, identified family...
Autophagy has been reported to be widely involved in the pathogenesis of osteoarthritis (OA). Increasing evidence suggested important role microRNAs (miRs) progression OA. However, functional miR‑17‑5p OA development remained fully elucidated. First, a mouse model was established and relative level determined using PCR. Safranin O‑fast green staining applied determine cartilage degeneration. TargetScan software dual luciferase reporter assay were potential target genes miR‑17‑5P. measurement...
MicroRNA-135b (miR‑135b) functions as an oncogene in malignant tumors suggesting that it might be a target for tumor therapy, but its role osteosarcoma has not been investigated to date. In this study, we found myocardin expression is specifically attenuated MG63 cells. Silencing miR‑135b restores the of and inhibits by targeting 3'UTR additional experiments, was highly expressed tissues promoted cell proliferation, migration invasion. Myocardin had opposite effects miR‑135b, which...
Abstract The expression of 15‐lipoxygenase‐1 (15‐ LOX ‐1) is downregulated in colon cancer and other major cancers, 15‐ ‐1 reexpression cells suppresses colonic tumorigenesis. Various lines evidence indicate that premetastatic stages tumorigenesis; nevertheless, the role loss epithelial metastases continues to be debated. Hypoxia, a common feature microenvironment, promotes prometastatic mechanisms such as upregulation hypoxia‐inducible factor ( HIF )‐1 α , transcriptional master regulator...
Circular RNAs (circRNAs), a new kind of non-coding RNAs, have gradually been proved to be critical regulators gene expression; however, the underlying mechanisms still need elaborated.In present study, we investigated role hsa-circ-0007766 in gastric carcinoma (GC).Quantitative real-time PCR was applied detect differential expression levels circRNA, miRNAs, and mRNAs human tissues specific cell lines.GC lines were transiently transfected with siRNA.Then proliferation, migration, invasion...
There are occupational disparities in the risk of contracting COVID-19. Occupational characteristics and work addresses play key roles tracking down “patient zero.” The present descriptive analysis for management measures sporadic COVID-19 outbreaks from June to December 2020 China offers important new information international community at this stage pandemic. These data suggest that Chinese including zero,” launching mass testing SARS-CoV-2-positive areas, designating a high- or...
The high incidence of patients with chronic itch highlights the importance fundamental research. Recent advances in interface gut microbiota have shed new light into exploring this phenomenon. However, it is unknown whether plays a role rodents or without cognitive dysfunction. In study, diphenylcyclopropenone (DCP)-evoked was investigated mice and hierarchical cluster analysis novel object recognition test (ORT) results were used to classify DCP-evoked model dysfunction (CD)-like phenotype...
To explore proliferation of glomerular mesangial cells (GMC) and secretion extracellular matrix (fibronectin induced by sublytic C5b-9 complexes), then ascertain the role phosphatidylinositol 3-kinase (PI3-k)/Akt signal pathway in these processes, using small hairpin RNAs.