A5100361596- Advanced biosensing and bioanalysis techniques
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Medical Imaging Techniques and Applications
- Enzyme function and inhibition
- DNA and Nucleic Acid Chemistry
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Statistical Methods and Inference
- Bone and Joint Diseases
- Orthopedic Infections and Treatments
- Statistical Distribution Estimation and Applications
- Microbial Inactivation Methods
- Nanoplatforms for cancer theranostics
- Atherosclerosis and Cardiovascular Diseases
- Radiomics and Machine Learning in Medical Imaging
- Biosensors and Analytical Detection
- Hemoglobin structure and function
- Statistical Methods and Bayesian Inference
- Spinal Dysraphism and Malformations
- Electrochemical sensors and biosensors
- Extracellular vesicles in disease
- Neurological Disease Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
Inner Mongolia Medical University
2015-2025
The First People's Hospital of Changde
2022
Hebei Medical University
2021
Fourth Hospital of Hebei Medical University
2021
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2020
Inner Mongolia Autonomous Region Meteorological Bureau
2020
Second Affiliated Hospital of Inner Mongolia Medical University
2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
National Health and Family Planning Commission
2020
Background and Aims Tumor metastasis is a major factor of high recurrence mortality in hepatocellular carcinoma (HCC), but its underlying mechanism remains elusive. We report that PDZ LIM domain protein 1 (PDLIM1) significantly down‐regulated metastatic human HCC tissues, which predicts unfavorable prognosis, suggesting PDLIM1 may play an important inhibitory role during metastasis. Approach Results Functional studies indicate knockdown induces epithelial‐to‐mesenchymal transition (EMT)...
Aptamers are single-stranded oligonucleotides with specific spatial structures. They have been widely used in preclinical studies because of their high affinity and specificity for various biological targets. AS1411, an aptamer targeting the nucleolin overexpressed on cancer cell membrane, is one most promising extensively studied aptamers. However, extremely low bioavailability due to rapid renal excretion remains a great obstacle aptamers' clinical translation. Human serum albumin (HSA),...
Background: Acute liver injury (ALI) is a prevalent and potentially lethal condition globally, where pharmacotherapy plays vital role. However, challenges such as rapid drug excretion insufficient concentration at hepatic lesions often impede the treatment’s effectiveness. Methods: We successfully prepared glycyrrhizinate monoammonium cysteine (GMC)-loaded lipid nanoparticles (LNPs) using high-pressure homogenization. The characterization safety of LNPs were measured electrophoretic light...
SYL3C is an optimized DNA aptamer with high selectivity and affinity for the epithelial cell adhesion molecule (EpCAM), overexpressed tumor antigen in colorectal cancer (CRC). While its cellular has been validated, vivo studies are lacking. This study modifies fluorescent motif Cy7 to evaluate metabolism diagnostic potential EpCAM-positive HT-29 xenograft mice using near-infrared fluorescence (NIRF). We also employ Tetrahedra (DTN) load Cy7-DTN-SYL3C probe assess whether this strategy...
This study aimed to develop and validate radiomics-based nomograms for the identification of EGFR mutations in non-small cell lung cancer (NSCLC). A retrospective analysis was performed on 313 NSCLC patients, who were randomly divided into training (n = 250) validation 63) groups. Radiomic features extracted from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) thin-section computed (CT) scans. After selecting optimal radiomic features, four machine learning algorithms,...
The purpose of this study was to observe the effect fasting and feeding on <sup>18</sup>F-FDG uptake in a mouse model human non–small cell lung cancer. <b>Methods:</b> In vivo studies, small-animal PET scans were acquired 5 mice bearing cancer A549 xenografts each flank with continuous after overnight changes intratumoral distribution tumor standardized value (SUV). ex spatial assessed by autoradiography compared microenvironment (including hypoxia pimonidazole stroma hematoxylin eosin...
Self-assembled DNA nanostructures, as a new type of nanocarriers, have shown great potential in molecular imaging probes. bipyramid nanostructures (DBNs), classic kind nanostructure, can be precisely constructed through the unparalleled base-pairing precision oligonucleotide strands. DBNs were prepared by self-assembly six oligonucleotides with equal molar amounts single annealing step, and purified high performance liquid chromatography (HPLC). stable 10% FBS well 80% mouse serum for at...
Objective To evaluate 125I-labeled anti-carbonic anhydrase IX monoclonal antibody (125I-MAb) as a novel single-photon emission computed tomography tracer for imaging carbonic in the mice bearing HT-29 tumors. Methods Anti-carbonic was labeled with iodine-125 by iodogen method. The radiochemical purity of 125I-MAb measured radio-thin-layer chromatography. in-vitro stability determined PBS (0.05 mol/l, pH 7.4) or new-born calf serum at 37°C, and analyzed A biodistribution study planar were...
The CL signal was amplified by CRET in CdTe QDs@luminol to improve the sensitivity and CsMG-MIP introduced selectivity.
Abstract To develop a DNA aptamer-based PET tracer for imaging of glioblastoma. 5 mM NOTA-AS1411, 60-min, and 37 °C were selected as the optimal condition 64 Cu radiolabeling AS1411. Cu-NOTA-AS1411 remained stable in PBS 100% mouse serum at least six hours. From images, tended to be excreted out through kidneys there was high accumulation bladder. There higher tumor uptake AS1411 group than that control group. is suitable potential murine
This essay aims to make investigation on the mechanism of glucose metabolism disorder and Lipopolysaccharide administration-induced cognitive function impairment in adult rats with surgery. Divide objects, 40 male Sprague-Dawley at age 9 months, into 4 groups. Provide unilateral nephrectomy surgery and/or lipopolysaccharide intraperitoneal injection. Postoperative evaluation would be tested by Morris water maze. Rats Cognitive Dysfunction (POCD) were scanned analyze brain means 18F-FDG...
We constructed 68 Ga-BDF and employed PET imaging to establish its pharmacokinetic model. BDF was eliminated from the body via urinary system. observed distinct indicators in UUO AKI mouse models. Furthermore, we therapeutic effect of on AKI.
A novel electrochemical aptasensor based on Klenow Fragment induced extension reaction has been developed successfully for the ultrasensitive detection of platelet-derived growth factor (PDGF) protein. In presence target protein, recognition probe changed its hairpin conformation and gave a 3-single-stranded sequence complementary to biotinylated primer. polymerase reaction, served as template capture probe, then protein was released from replicated DNA duplex subsequently could bind with...
It has been proven that vitamin D was decreased and function of circulating endothelial progenitor cells (EPCs) injured in systemic lupus erythematosus (SLE) patients. However, the effect on EPCs vitro its mechanism need further study. Therefore, we investigated whether improved vitro. The peripheral blood mononuclear participants were isolated from SLE patients control subjects cultured to EPCs. After treated with (1,25-(OH)2D3), evaluated number, migratory proliferative activities, nitric...
Abstract Background At present, the early diagnosis of femoral head necrosis mainly relies on Magnetic resonance imaging (MRI), and most patients are difficult to make an accurate diagnosis. Therefore, investigate diagnostic value 99m Tc-Cys-Annexin V Single-photon emission computed tomography (SPECT) were compared with MRI in rabbit models steroid-induced necrosis. Methods The animal model (SIFHN) was established 5-month-old healthy New Zealand white rabbits by injecting horse serum into...
Objective . To validate the ability of 99m Tc-Annexin V to visualize early stage glucocorticoid-induced femoral head necrosis by comparing with Tc-MDP bone scanning. Methods Femoral was induced in adult New Zealand white rabbits intramuscular injection methylprednisolone. scintigraphy and scans were performed before 5, 6, 8 weeks after methylprednisolone administration. Rabbits sacrificed at various time points conducted for TUNEL H&E staining. Results All treated animals developed...
Near-infrared fluorescence (NIRF) imaging technology is a highly sensitive modality and has been widely used in noninvasively studying the status of receptor expression small animal models, with an appropriate NIRF probe targeting specific receptor. In this report, Cy5.5-conjugated anti-CAIX monoclonal antibody (Mab-Cy5.5) was evaluated athymic mice bearing HT-29 tumor xenografts order to investigate effect conjugate on efficacy. vitro binding studies showed that Mab-Cy5.5 could specifically...