A5102005165- Quantum and electron transport phenomena
- Advancements in Semiconductor Devices and Circuit Design
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Semiconductor materials and devices
- Semiconductor Quantum Structures and Devices
- Total Knee Arthroplasty Outcomes
- Neurological Disease Mechanisms and Treatments
- Orthopaedic implants and arthroplasty
- Magnetic properties of thin films
- Advanced Radiotherapy Techniques
- Reconstructive Surgery and Microvascular Techniques
- Pelvic and Acetabular Injuries
- Surgical Sutures and Adhesives
- Knee injuries and reconstruction techniques
- Radiation Therapy and Dosimetry
- Sarcoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Spinal Fractures and Fixation Techniques
- Quantum Computing Algorithms and Architecture
- Orthopedic Infections and Treatments
- Hemostasis and retained surgical items
University of Science and Technology of China
2019-2025
Quantum (Australia)
2025
Chinese PLA General Hospital
2016-2024
CAS Key Laboratory of Urban Pollutant Conversion
2020-2023
Ruijin Hospital
2022
Shanghai Jiao Tong University
2022
Hong Kong Polytechnic University
2020
Shanghai University of Medicine and Health Sciences
2020
Pudong New Area People's Hospital
2020
Chinese People's Liberation Army
2020
To test the utility of "A/T/N" system in Chinese population, we study core Alzheimer's disease (AD) biomarkers a newly established cohort.
Abstract Background CSF-soluble platelet-derived growth factor receptor beta (sPDGFRβ) is closely associated with pericyte damage. However, the changes in CSF sPDGFRβ levels and their role blood – brain barrier (BBB) leakage at different stages of Alzheimer’s disease (AD), or without cerebral small vessel (CSVD) burden, remain unclear. Methods A total 158 individuals from China Aging Neurodegenerative Disorder Initiative cohort were selected, including 27, 48, 83 a clinical dementia rating...
In our toolbox of quantum gates for spin qubits, the SWAP-family based on Heisenberg exchange coupling are quite versatile: SWAP gate can help solve connectivity problem by realizing both short- and long-range state transfer, while is a basic two-qubit entangling gate. Here we demonstrate in double dot isotopically enriched silicon presence micromagnet. We achieve two-orders-of-magnitude adjustable ratio between J Zeeman energy difference ΔEz, overcoming major obstacle high-fidelity also...
In silicon quantum dots (QDs), at a certain magnetic field commonly referred to as the "hot spot," electron spin relaxation rate (T1−1) can be drastically enhanced due strong spin-valley mixing. Here, we experimentally find that with valley splitting of 78.2±1.6 μeV, this hot spot in suppressed by more than 2 orders magnitude when in-plane is oriented an optimal angle, about 9° from [100] sample plane. This directional anisotropy exhibits sinusoidal modulation 180° periodicity. We explain...
Preserving qubit coherence and maintaining high-fidelity control under complex noise environment is an enduring challenge for scalable quantum computing. Here we demonstrate addressable fault-tolerant single spin with average fidelity of 99.12% via randomized benchmarking on a silicon dot device integrated micromagnet. Its dephasing time ${T}_{2}^{\ensuremath{\ast}}$ $1.025\phantom{\rule{0.2em}{0ex}}\text{\ensuremath{\mu}}\mathrm{s}$, can be enlarged to...
Spin qubits based on silicon metal-oxide semiconductor (Si-MOS) quantum dots (QDs) are promising platforms for large-scale computers. To control spin in QDs, electric dipole resonance (EDSR) has been most commonly used recent years. By delocalizing an electron across a double charge state, “flopping-mode” EDSR realized Si/SiGe QDs. Here, we demonstrate flopping-mode qubit Si-MOS QD via Elzerman single-shot readout. When changing the detuning with fixed drive power, achieve s-shape...
Early-onset Alzheimer's disease (EOAD) exhibits a notable degree of heterogeneity as compared to late-onset (LOAD). The proteins and pathways contributing the pathophysiology EOAD still need be completed elucidated.
This study aimed to develop and validate radiomics-based nomograms for the identification of EGFR mutations in non-small cell lung cancer (NSCLC). A retrospective analysis was performed on 313 NSCLC patients, who were randomly divided into training (n = 250) validation 63) groups. Radiomic features extracted from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) thin-section computed (CT) scans. After selecting optimal radiomic features, four machine learning algorithms,...
Magnetic resonance imaging (MRI), combined with artificial intelligence techniques, has improved our understanding of brain structural change and enabled the estimation age. Neurodegenerative disorders, such as Alzheimer's disease (AD), have been linked to accelerated aging. In this study, we aimed develop a deep-learning framework that processes integrates MRI images more accurately predict age, cognitive function, amyloid pathology. pathology.We collected over 10,000 T1-weighted scans from...
Objective.This paper describes the development and validation of a GPU-accelerated Monte Carlo (MC) dose computing module dedicated to organ calculations individual patients undergoing nuclear medicine (NM) internal radiation exposures involving PET/CT examination.Approach. This new extends more-than-10-years-long ARCHER project that developed MC engine by adding NM source-definition features. To validate code, we compared distributions from point ion source, including18F,11C,15O, and68Ga,...
Blood-brain barrier (BBB) damage is considered an important part of Alzheimer's disease (AD) progression, and cerebral small-vessel (CSVD) commonly associated with AD. However, the relationship between BBB damage, small cerebrovascular lesions, especially microbleeds (CMBs), amyloid tau biomarkers remains controversial. Therefore, our study aimed to further investigate their association in cohort patients AD.A total 139 individuals were divided into probable AD (18F-florbetapir PET positive,...
The current diagnoses of Alzheimer's disease (AD) mainly rely on such measures as amyloid-β (Aβ) and tau neuropathology biomarkers in vivo via cerebrospinal fluid (CSF) positron emission tomography (PET) imaging, which had been systematically studied Caucasian individuals, whereas diagnostic performances these approaches Chinese dementia population still remain unclear. This study investigated the associations between levels CSF core AD biomarkers, including phosphorylated (p-Tau181), total...
High-fidelity singlet-triplet state readout is essential for large-scale quantum computing. However, the widely used threshold method of comparing a mean value with fixed will limit judgment accuracy, especially relaxed triplet state, under restriction relaxation time and signal-to-noise ratio. Here, we achieve an enhanced latching based on Pauli spin blockade in Si-MOS double dot device demonstrate average singlet-triplet-state fidelity 97.59% by method. We reveal inherent deficiency...
Blood-based biomarkers have been considered as a promising method for the diagnosis of Alzheimer's disease (AD). The reliability and accuracy plasma core AD biomarkers, including phosphorylated tau (P-tau181), total (T-tau), Aβ42, Aβ40, also confirmed in diagnosing predicting cerebral β-amyloid (Aβ) deposition Western populations, while fewer research studies ever conducted China's Han population. In this study, we investigated capability Aβ burden among China Aging Neurodegenerative...
[18F]-4-((E)-(((E)-4-(2-(2-(2-Fluoroethoxy)ethoxy)ethoxy)benzylidene)-hydrazono)methyl)-N-methylaniline ([18F]92) is a novel positron emission tomography (PET) tracer previously reported to exhibit high binding affinity aggregated β-amyloid (Aβ). This study aims report fully automated radiosynthesis procedure for [18F]92, explore its radioactive distribution in the brains of healthy subjects, and investigate potential application value early diagnosis Alzheimer's disease (AD). The [18F]92...
Tunable synthetic spin-orbit coupling (SSOC) is one of the key challenges in various quantum systems, such as ultracold atomic gases, topological superconductors, and semiconductor dots. Here we experimentally demonstrate controlling SSOC by investigating anisotropy spin-valley resonance a silicon dot. As rotate applied magnetic field plane, find striking nonsinusoidal behavior amplitude that distinguishes from intrinsic (ISOC), associate this with previously overlooked in-plane transverse...
In the last 20 years, silicon quantum dots have received considerable attention from academic and industrial communities for research on readout, manipulation, storage, near-neighbor long-range coupling of spin qubits. this paper, we introduce how to realize a single qubit Si-MOS dots. First, structure typical dot experimental setup. Then, show basic properties dot, including charge stability diagram, orbital state, valley lever arm, electron temperature, tunneling rate lifetime. After that,...
To summarize the research progress of medial buttress plate assisted fixation for femoral neck fractures in young adults.The literature about adults was widely reviewed and analyzed. The design principle, background, biomechanical characteristics, clinical results were summarized.Medial is latest treatment adults, which can convert shear force at fracture sides into compression promote healing. Medial improve stability reduce maximum stress implants. In clinical, maintain reduction,...