A5100694696- Photonic Crystals and Applications
- Mesenchymal stem cell research
- Metamaterials and Metasurfaces Applications
- Fern and Epiphyte Biology
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Obesity, Physical Activity, Diet
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Nutritional Studies and Diet
- Radioactivity and Radon Measurements
- Metal complexes synthesis and properties
- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
- Advanced Antenna and Metasurface Technologies
- Cancer Mechanisms and Therapy
- Osteoarthritis Treatment and Mechanisms
- Metal-Organic Frameworks: Synthesis and Applications
- Nutrition, Genetics, and Disease
- Sperm and Testicular Function
- Antioxidant Activity and Oxidative Stress
- Natural Antidiabetic Agents Studies
- interferon and immune responses
Nanchang University
2024-2025
Second Hospital of Hebei Medical University
2024-2025
Hebei Medical University
2024-2025
Ollscoil na Gaillimhe – University of Galway
2024-2025
Tsinghua University
2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Peking University
2022-2024
Sun Yat-sen University
2020-2024
Second Affiliated Hospital of Harbin Medical University
2020-2024
Harbin Medical University
2014-2024
Background Depression escalating public health concern and the modest efficacy of currently available treatments have prompted efforts to identify modifiable risk factors associated with depression symptoms. Physical inactivity, poor nutrition, or other lifestyle behaviors are among potentially most consistently linked depression. Past evidence regarding single effect physical activity (PA) dietary quality (DQ) on reducing symptoms has been well-documented. However, association joint PA DQ...
Artemisia pollen allergy is a major cause of asthma in Northern China. Possible associations between IgE responses to allergen components and clinical phenotypes have not yet been evaluated. This study was establish sensitization patterns four allergens possible with demographic characteristics three areas China.Two hundred forty patients allergic were examined, 178 from Shanxi 30 Shandong Provinces China, 32 Yunnan Province Southwestern Allergic asthma, rhinitis, conjunctivitis, eczema...
Objective: To elucidate the potential causality of leukocyte telomere length (LTL) with immune-mediated inflammatory diseases (IMIDs), we conducted a Mendelian randomization (MR) study. Methods: The genetically predicted causation between LTL and IMIDs was evaluated using two-sample MR method. We analyzed 16 major IMIDs, which included systemic lupus erythematosus (SLE), bowel disease (IBD), ulcerative colitis (UC), Crohn's (CD), ankylosing spondylitis (AS), sicca syndrome (SS), rheumatoid...
This study aimed to investigate the impact of a common non-synonymous gene variant (C>G, rs738409) in patatin-like phospholipase domain-containing 3 (PNPLA3), leading substitution isoleucine with methionine at position 148 (PNPLA3-I148M), on susceptibility nonalcoholic fatty liver disease (NAFLD) and explore potential therapeutic nutritional strategies targeting PNPLA3. It contributed understanding sustainable dietary practices for managing NAFLD, recently referred as...
Lupus nephritis (LN) is a major determinant of morbidity and mortality in systemic lupus erythematosus (SLE). Pim-1 regulates lymphocyte proliferation activation. The role autoimmune disease remains unclear. This study was undertaken to test the hypothesis that inhibition would have therapeutic potential patients with LN.Pim-1 expression analyzed lupus-prone (NZB × NZW)F1 mice (n = 6), human peripheral blood mononuclear cells (PBMCs) from SLE 10), glomeruli LN 8). effect inhibitor AZD1208...
Abstract Androgen receptor (AR) signaling inhibitors provide limited survival benefits to patients with prostate cancer (PCa), and worse, few feasible genomic lesions restrict targeted treatment PCa. Thus, a better understanding of the critical dependencies PCa may enable more therapeutic approaches dilemma. We performed kinome-scale CRISPR/Cas9 screen identified cyclin-dependent kinase 12 (CDK12) as being conservatively required for cell survival. Suppression CDK12 by covalent inhibitor...
Tendon and ligament ruptures are prevalent, severe sports injuries require surgical repair. In clinical practice, monitoring of tissue strain is critical to alert postoperative complications such as graft reinjury loosening. Here, we present a sensor system that integrates communication coil onto silk sutures, enabling in situ wireless readout strains via implantation. The flexible shows excellent adaptability soft tissues, providing range 0 10% with minimum detection threshold 0.25%...
ABSTRACT Fabric Filter (FF) and Electrostatic‐Fabric Integrated Precipitator (EF) are the main equipment for industrial flue dust control, but their energy consumption levels not yet clear especially after ultra‐low emission. In this paper, efficiency data of 22 sets FF 21 EF before emission, 9 62 emission systematically studied analyzed by field testing technical investigation. The results showed that converted CO 2 in coal‐fired power plants increased significantly. For (EF), specific...
To investigate the prevalence and risk factors of visual impairment associated with refractive error unmet need for spectacles in a special suburban senior population Baoshan District Shanghai, one several rural areas undergoing transition from to urban area, where data are limited.The study was based survey 4545 Chinese aged (age: >60 years or older ) at Baoshan, 2009. One copy questionnaire completed each subject. Examinations included standardized refraction measurement presenting best...
ObjectiveTo investigate microRNA (miRNA) expression profiles in the seminal plasma of nonobstructive azoospermia (NOA) patients with different histopathologic patterns and evaluate potential noninvasive diagnostic biomarkers NOA.DesignSequencing validation using quantitative reverse transcription polymerase chain reaction (qRT-PCR).SettingReproductive center research institute.Patient(s)Thirteen NOA (7 Sertoli cell–only syndrome [SCOS] 6 hypospermatogenesis to spermatogenesis arrest [SA]) 7...
Application of differentiation therapy targeting cellular plasticity for the treatment solid malignancies has been lagging. Nasopharyngeal carcinoma (NPC) is a distinctive cancer with poor and high prevalence Epstein-Barr virus (EBV) infection. Here, we show that expression EBV latent protein LMP1 induces dedifferentiated stem-like status through transcriptional inhibition CEBPA. Mechanistically, upregulates STAT5A recruits HDAC1/2 to CEBPA locus reduce its histone acetylation. HDAC restored...
Class switch recombination (CSR) diversifies the effector functions of antibodies and involves complex regulation transcription DNA damage repair. Here, we show that deubiquitinase USP7 promotes CSR to immunoglobulin A (IgA) suppresses unscheduled IgG switching in mature B cells independent its role repair, but through modulating region germline transcription. depletion impairs Sα transcription, leading abnormal activation Sγ increased interaction with center via loop extrusion for...
Abstract Rheumatoid arthritis ( RA ) is a chronic inflammatory disease characterized by joint swelling, tenderness and destruction of synovial joints, leading to severe disability. Anti‐inflammatory drugs disease‐modifying anti‐rheumatic DMARD s) may improve process. However, in most patients the treatment effect still not satisfactory. Cyclin‐dependent kinase 7 (CDK7) plays well‐established role regulation eukaryotic cell division cycle, recent studies indicated that it exerted...