A5101814547- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Behavioral Health and Interventions
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Head and Neck Cancer Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Transgenic Plants and Applications
- Delphi Technique in Research
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Voice and Speech Disorders
- Cell Adhesion Molecules Research
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Plant-based Medicinal Research
- Epigenetics and DNA Methylation
- Microbial Inactivation Methods
- Yersinia bacterium, plague, ectoparasites research
First Hospital of Shanxi Medical University
2011-2025
Shanxi Medical University
2011-2025
Shandong Normal University
2024
Shanxi Provincial Cancer Hospital
2021
Artemisia pollen allergy is a major cause of asthma in Northern China. Possible associations between IgE responses to allergen components and clinical phenotypes have not yet been evaluated. This study was establish sensitization patterns four allergens possible with demographic characteristics three areas China.Two hundred forty patients allergic were examined, 178 from Shanxi 30 Shandong Provinces China, 32 Yunnan Province Southwestern Allergic asthma, rhinitis, conjunctivitis, eczema...
Background: Mounting evidence supports the efficacy of sublingual immunotherapy (SLIT) due to its favorable safety profile and convenience. However, there is limited research comparing SLIT between adults children. Objective: The aim this prospective study contribute additional corroborative findings by evaluating a vaccine formulated with Artemisia annua extracts in children adult patients seasonal allergic rhinoconjunctivitis (SARC). Methods: SARC (n = 75, group: 49, control 26) were...
There are two major forms of the Fas molecule, membranous and soluble (sFas). To clarify clinical significance sFas in autoimmune diseases, we designed a sandwich ELISA to determine serum concentrations its molecular structure, then analysed correlation between levels laboratory findings patients with SLE other diseases. The were significantly higher than subjects diseases healthy donors, frequency positive was much greater high disease activity index scores those low scores. In addition,...
Artemisia weed pollen allergy is important in the northern hemisphere. While over 350 species of this genus have been recorded, there has no full investigation into whether different may affect allergen diagnosis and treatment. This study aimed to evaluate variations amino acid sequences content major allergens, how these specific IgE binding capacity representative species.
The dysfunction of regulatory B cells (Breg) may result in immune inflammation such as allergic rhinitis (AR); the underlying mechanism is not fully understood yet. Short-chain fatty acids, propionic acid (PA), have functions. This study aimed at testing a hypothesis that modulates PA production alleviating airway allergy through maintaining Breg were isolated from blood obtained AR patients and healthy control (HC) subjects. stabilization IL-10 mRNA was tested with RT-qPCR. An mouse model...
This study was to investigate the relationship between spring pollen distribution concentration, species and detection results of air-borne allergens in Taiyuan City, Shanxi Province during March May 2022 2023.A retrospective conducted Otorhinolaryngology Head Neck Surgery Clinic First Hospital Medical University.Pollen particles will be monitored by gravity sedimentation method on roof outpatient department University downtown from 2022-2023, quantity observed recorded under an optical...
Abstract Allergen‐specific immunotherapy (AIT) is an aetiology‐targeting therapy for allergic diseases. The therapeutic mechanism of AIT not fully understood yet. Endoplasmic reticulum stress associated with the pathogenesis disorders. This study aims to elucidate effects on suppressing response through regulating endoplasmic stress. In this study, patients perennial rhinitis were recruited. was conducted patients. An (AR) mouse model established mite extracts as allergens. We found that...
The mechanism of antigen-specific regulatory T cell (Treg ) induction is not yet fully understood. Curcumin has an immune function. This study aims to induce Tregs by employing extracellular vesicles (EVs) that carry two types activators. Two activators, ovalbumin (OVA)/major histocompatibility complex-II (MHC-II) and tetramethylcurcumin (FLLL31) (a curcumin analog) were carried dendritic cell-derived vesicles, designated OFexo. A murine model allergic rhinitis (AR) was developed with OVA as...
Rationale: Mast cells play a crucial role in allergic diseases.Yet, the regulation of mast cell bioactivities is not fully understood.This study aims to elucidate B lymphoma 2 like protein 12 (Bcl2L12), one anti-apoptosis proteins, regulating apoptosis.Methods: A food allergy (FA) mouse model was developed establish over population intestinal tissue.Either compound 48/80 (C48/80) or specific antigens were used activate mucosa.Results: After treating with C48/80, apoptosis induced intestine...
ObjectiveThis study aimed to confirm the efficacy of an intervention based on information-motivation-behavior skills (IMB) model in improving sublingual immunotherapy adherence score, medication beliefs self-efficacy and knowledge score patients with allergic rhinitis.MethodsA total 120 rhinitis from otorhinolaryngology clinic were divided into control group (n = 60) experimental 60); was conducted August 2021 March 2022. The received routine intervention, whereas IMB model. adherence,...
Objective:To observe the auxiliary curative effect of combined clostridium and bifidobacterium capsules, live (also called Changlekang) in treatment allergic rhinitis by comparing IL-10, transforming growth factor-β1(TGF-β1), quality life score symptom before after oral Changlekang.Method:Twenty qualified patients study group 20 control were enrolled.The was given changlekang, desloratadine citrate disodium tablets mometasone furoate nasal spray for treatment. After 2 weeks treatment,...
Objective To study the DNA methylation of nucleated cells in peripheral blood patients died from anaphylactic shock caused by cephalosporin drugs and to provide a new research direction basis for forensic diagnosis drug hypersensitiveness. Methods Methylation microarray was used detect normal subjects. Sequencing data chip were analyzed differences using R language methylkit, ChAMP package. Random forest algorithm evaluate importance differential sites. Results Differential sites highly...
To study the efficacy and compliance analysis of pollen allergen drops in treatment allergic rhinitis. The method single-center controlled was used to analyze dates' results. From July 2021 September 2021, 80 patients with seasonal rhinitis were referred clinic otorhinolaryngology First Hospital Shanxi Medical University.40 received sublingual immunotherapy (SLIT group), other 40 symptomatic drug as control group. total rhinoconjunctivitis symptom score (TRSS), visual analogue scale(VAS),...
Objective: To investigate the damage and mechanism of artemisia annua pollen on tight junction human nasal mucosa epithelial cells (HNEpC). Methods: HNEpC were cultured in vitro. Different concentrations (0, 20, 40, 80, 100, 160, 200 μg/ml) used to intervene for 24 h, cell proliferation activity was detected by CCK-8 method. The expression phosphorylation p38MAPK signaling pathway Western Blot before after intervention SB203580, a inhibitor HNEpC. Immunofluorescence chemical staining,...