A5100414145- Surface Modification and Superhydrophobicity
- Lipid Membrane Structure and Behavior
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Sensor and Energy Harvesting Materials
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Adhesion, Friction, and Surface Interactions
- CAR-T cell therapy research
- Aerogels and thermal insulation
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Allergic Rhinitis and Sensitization
- Innovative Microfluidic and Catalytic Techniques Innovation
- Asthma and respiratory diseases
- Microfluidic and Bio-sensing Technologies
- Polymer composites and self-healing
- Membrane Separation Technologies
- Dermatology and Skin Diseases
- Advanced Photocatalysis Techniques
- Thermochemical Biomass Conversion Processes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Muscle activation and electromyography studies
University of Illinois Chicago
2014-2025
Shanxi Medical University
2023-2025
First Hospital of Shanxi Medical University
2023-2025
Southwest University of Science and Technology
2023-2024
Zhejiang University
2024
Ocean University of China
2015-2024
Nanchang University
2023-2024
Anhui Agricultural University
2024
University of Cambridge
2024
Cardiff University
2024
Working mechanism of self-healing, superhydrophobic coatings.
Our previous study indicated that GPC3-targeted chimeric antigen receptor (CAR) T cell therapy has a high safety profile in patients with hepatocellular carcinoma (HCC). However, the response rate requires further improvement. Here, we analyzed combined effect of GPC3-CAR cells and sorafenib both immunocompetent immunodeficient mouse models carcinoma. In model, CAR (mCAR) induced regression small tumors (approximately 130 mm3 tumor volume) but had no on large, established 400 volume)....
Slippery liquid-infused porous surfaces (SLIPSs) have recently been intensively investigated because of promising potential in various applications that require water repellency. However, the use SLIPS is limited by its unsatisfactory oil-storage and -replacement capabilities. Here we designed network surface structures with interconnected microchannels cross-linked nanosheets, which acted as natural oil reservoirs vessels. A lubricant can be firmly locked stored into networks, leading to an...
Osteoarthritis (OA) is characterized by cartilage damage, inflammation, and pain. Vascular endothelial growth factor receptors (VEGFRs) have been associated with OA severity, suggesting that inhibitors targeting these alleviate pain (via VEGFR1) or degeneration VEGFR2). We developed a nanoparticle-based formulation of pazopanib (Votrient), an FDA-approved anticancer drug targets both VEGFR1 VEGFR2 (Nano-PAZII). demonstrate single intraarticular injection Nano-PAZII can effectively reduce...
Tunable water adhesion was realized on a TiO(2) nanotube film with patterned wettability formed via selective illumination through mask. Meanwhile, the can be switched between sliding superhydrophobicity and sticky by masked heat annealing.
To increase the understanding of reaction behavior heavy hydrocarbons in presence sub- and supercritical water, upgrading residual oil was applied a batch reactor at temperatures 653 to 713 K water densities 0.05 0.20 g/cm3. It is confirmed that still dominated by free radical mechanism based thermal cracking. The ion hydrolysis only has an extremely limited influence on performance. With density, system may evolve from partially miscible two-phase structure pseudo single-phase which...
This paper presents a facile method for preparing Ag nanoparticle (NP)-loaded superamphiphobic surfaces on an Al substrate with efficient anticorrosion and antibacterial properties. A hierarchical steplike microstructure nanopores is fabricated surface through chemical etching anodization; subsequent fluorination confers superhydrophobic superoleophobic properties to this surface. NPs are loaded the stabilized by self-assembled aminopropyltriethoxysilane monolayer amino-group bonding prevent...
Nanofibrillated cellulose (NFC)-based aerogels have been widely used for various applications. However, the disadvantages of poor structural stability, low mechanical toughness, and easy contamination by bacteria hinder their large-scale application. In this work, 3-(3'-acrylicacidpropylester)-5,5-dimethyl hydantoin (APDMH) was grafted on oxidized NFC (ONC) to prepare antibacterial poly(APDMH)-g-ONC (PAC). PAC poly(ethyleneimine) (PEI) were chemically cross-linked using...
Recently, replacing chemical fertilizers with straw returning and new has received considerable attention in the agricultural sector, as it is believed to increase rice yield improve soil properties. However, less known about growth properties paddy fields addition of different fertilizers. Thus, this paper, we investigated effects fertilizer treatments, including no fertilization (CK), optimized based on medium recommended amount (OF), 4.50 Mg ha−1 (SF), 0.59 slow-release (SRF), 0.60...
Aligned samples of lipid bilayers have been fully hydrated from water vapor in a different type x-ray chamber. Our use aligned resolves issues concerning the ripple phase that were ambiguous previous powder studies. In particular, our diffraction data conclusively demonstrate that, on cooling ${L}_{\ensuremath{\alpha}}$ to ${P}_{{\ensuremath{\beta}}^{\ensuremath{'}}}$ phase, both chiral and racemic dipalmitoyl phosphatidylcholine (DPPC) exhibit coexistence long short ripples with wavelength...
Ninety percent of relapse/refractory B-cell acute lymphatic leukemia (R/R B-ALL) patients can achieve complete remission (CR) after CD19-targeting chimeric antigen receptor T (CAR-T) cell therapy. However, around 50% them relapse in 1 year. Persistent CAR-T engraftment is considered as the key to remain durable remission. Here, we initiated a phase I study treat 10 pediatric B-ALL using CD19-targeted second generation CAR with 4-1BB intracellular costimulatory domain. All received standard...
Abstract Biological particle separation has wide applications in medical diagnosis, bioengineering, and various other domains. Traditional methods, such as filtration, density gradient centrifugation, size exclusion chromatography, face many challenges, including low resolution, purity, the inability to be seamlessly integrated into continuous processes. The development of microfluidics paved way for efficient precise biological separation. Microfluidic chip‐based methods can generally...
Secretory phospholipase A2 (sPLA2), an enzyme overexpressed in numerous diseases, has been used to trigger structural transformations lipid-based drug delivery systems, enabling payload release at target sites. Zwitterionic peptides are known for their superior antifouling properties, often outperforming poly(ethylene glycol) (PEG) surface modification by resisting protein adsorption. In this study, we examined lipid monolayers the water–vapor interface on a Langmuir trough, incorporating...
Background: Mounting evidence supports the efficacy of sublingual immunotherapy (SLIT) due to its favorable safety profile and convenience. However, there is limited research comparing SLIT between adults children. Objective: The aim this prospective study contribute additional corroborative findings by evaluating a vaccine formulated with Artemisia annua extracts in children adult patients seasonal allergic rhinoconjunctivitis (SARC). Methods: SARC (n = 75, group: 49, control 26) were...
A large group of functional nanomaterials employed in biomedical applications, including targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads via self-assembly processes. Knowledge the micelle structures will provide critical insights into design polymeric delivery systems. Core-shell micelles composed linear diblock copolymers poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL), oxide)-b-poly(lactic acid) (PEG-b-PLA), as well a heterografted brush...
Size-controlled granular polyphosphate (PolyP) nanoparticles were synthesized by precipitation in aqueous solutions containing physiological concentrations of calcium and magnesium. We demonstrate using dynamic light scattering (DLS) that the solubility is correlated inversely with PolyP chain length, very long (PolyP1000+, more than 1000 repeating units) normally found prokaryotes precipitating much robustly shorter chains like those human platelet dense granules (PolyP80, range 76–84...
Chronic use of opioid analgesics has been hindered by the development addiction and tolerance. We have reported that curcumin, a natural flavonoid from rhizome <i>Curcuma longa,</i> attenuated tolerance, although underlying mechanism remains unclear. In this study, we tested hypothesis curcumin may inhibit Ca<sup>2+</sup>/calmodulin-dependent protein kinase II <i>α</i> (CaMKII<i>α</i>), previously proposed to be critical for tolerance dependence. used state-of-the-art polymeric formulation...