A5081889729- Chemotherapy-induced organ toxicity mitigation
- Nigella sativa pharmacological applications
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Pain Mechanisms and Treatments
- Renin-Angiotensin System Studies
- Osteoarthritis Treatment and Mechanisms
- Arsenic contamination and mitigation
- Cancer Treatment and Pharmacology
- Nuclear Receptors and Signaling
- Sodium Intake and Health
- Drug-Induced Hepatotoxicity and Protection
- Cytokine Signaling Pathways and Interactions
- Parkinson's Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Mesenchymal stem cell research
- Selenium in Biological Systems
- Biomedical Research and Pathophysiology
- Nitric Oxide and Endothelin Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Eicosanoids and Hypertension Pharmacology
University of Illinois Chicago
2023-2024
University of Houston
2019-2023
Aligarh Muslim University
2014-2021
Institute of Medical Sciences
2017
University of Missouri–St. Louis
2017
Osteoarthritis (OA) is characterized by cartilage damage, inflammation, and pain. Vascular endothelial growth factor receptors (VEGFRs) have been associated with OA severity, suggesting that inhibitors targeting these alleviate pain (via VEGFR1) or degeneration VEGFR2). We developed a nanoparticle-based formulation of pazopanib (Votrient), an FDA-approved anticancer drug targets both VEGFR1 VEGFR2 (Nano-PAZII). demonstrate single intraarticular injection Nano-PAZII can effectively reduce...
Cisplatin (CP) is a potent anti-cancer drug widely used against solid tumors. However, it exhibits pronounced adverse effects including hepatotoxicity. Several strategies were attempted to prevent CP hepatotoxicity but not found suitable for therapeutic application. Nigella sativa has been shown prevent/reduce the progression of certain type cardiovascular, kidney and liver diseases. Present study investigates whether N. oil (NSO) can induced hepatotoxic effects. Rats divided into four...
Oxidative stress and renal inflammation play a pivotal role in the pathogenesis of hypertension. The redox-sensitive transcription factor, nuclear factor E2-related 2 (Nrf2) is master regulator phase II antioxidant enzymes that protects against oxidative inflammation. This study aimed to investigate effect Nrf2 inhibition on stress-associated hypertension dopamine 1 receptor (D1R) dysfunction mice. Male C57BL/6 J mice were treated with pro-oxidant, L-buthionine sulfoximine (BSO) (10 mmol/L...
Hepatotoxicity is a major dose-limiting side effect of CP chemotherapy besides nephrotoxicity and gastrointestinal dysfunction. TQ, principal Nigella sativa seed oil constituent, has been shown to improve hepatic functions in various vivo models acute injury. In view this, the present study aimed evaluate TQ against CP-induced hepatotoxicity. Rats were divided into four experimental groups; control, CP, CP+TQ TQ. Animals groups administered (1.5 mg/kg bwt, orally), with or without single...
The effect of 1, 3 and 5-day fasting was studied on serum parameters; enzymes brush border membrane carbohydrate metabolism; transport Pi proline in different parts the rat kidney. Fasting decreased activities lactate dehydrogenase, malate dehydrogenase but increased glucose-6-phosphatase fructose 1,6-bisphosphatase; glucose-6-phosphate malic enzyme. These observations suggest that degradation glucose is its production by gluconeogenesis enhanced upon fasting. led to significant decrease...
Background: Cisplatin (CP) is an effective chemotherapeutic agent widely used against various malignancies. However, CP exerts several side effects through oxidative stress by generating reactive oxygen species (ROS). The major effect of chemotherapy dose dependent nephrotoxicity that limits its clinical usage. We have previously shown fish oil (FO) supplementation ameliorated gentamicin induced as evident increase in the activities brush border membrane (BBM) and free radical scavenging...
and HMP-shunt pathway but enzymes of gluconeogenesis were increased by fasting in rat intestine kidney [2,10].BBM biomarker transport Pi was also decreased 1, 3, 5 d superficial juxta-medullary cortex [10].Now we have determined the effect fasting-re-feeding on carbohydrate metabolism, BBM homogenates and/ or BBMVs prepared from whole (BBMV-WC), (BBMV-SC) (BBMV-JMC) kidney.The simultaneously under same experimental conditions freshly vesicles.The results show that caused significant decrease...
Angiotensin (Ang) 1-7, a bioactive heptapeptide of the renin-angiotensin aldosterone system is known to exert antioxidant and nephroprotective effects. However, cellular mechanisms involved in beneficial effect Ang 1-7 not entirely understood. Here, we studied on H2 O2 -mediated oxidative damage, endoplasmic reticulum (ER) stress apoptosis human proximal tubular (HK2) cells specific mechanisms. HK2 were incubated with (500 µM) pre-treated without (100 nM). We measured reactive oxygen species...