The ability of bacteria to develop antibiotic resistance and colonize abiotic surfaces by forming biofilms is a major cause medical implant-associated infections results in prolonged hospitalization periods patient mortality. Different approaches have been used for preventing biofilm-related health care settings. Many these methods their own demerits that include chemical-based complications; emergent antibiotic-resistant strains, so on. Silver nanoparticles (AgNPs) are renowned influential...

The antibacterial effect of AgNPs was investigated by determining MIC/MBC and growth kinetics assay. lowest found to be in the range 11.25–22.5 µg ml −1 . curve shows that 25 strongly inhibits bacterial growth. Confocal laser scanning electron microscopy (CLSM) as concentration NPs increases, reduction number cells observed at 50 NPs, 100% death noticed. Scanning (SEM) were severely damaged with pits, multiple depressions, indentation on cell surface original rod shape has swollen into...

Background Photodynamic therapy (PDT) has been found to be effective in inhibiting biofilm producing organisms. We investigated the photodynamic effect of gold nanoparticle (GNP) conjugated photosensitizers against Candida albicans biofilm. also examined efficacy photosensitizer (PS) GNPs (GNP-PS) treat skin and oral C. infection BALB/c mice. Methods The biomimetically synthesized were viz. methylene blue (MB) or toluidine O (TB). conjugation PSs with was characterized by spectroscopic...

Clinical isolates ( n = 55) of Pseudomonas aeruginosa were screened for the extended spectrum β‐lactamases and metallo‐β‐lactamases activities biofilm forming capability. The aim study was to demonstrate antibiofilm efficacy gum arabic capped‐silver nanoparticles (GA‐AgNPs) against multi‐drug resistant (MDR) P. . GA‐AgNPs characterized by UV‐spectroscopy, X‐ray diffraction, high resolution‐transmission electron microscopy analysis. their ability, using Congo red agar, tube method tissue...

Potassium bromate (KBrO3) is widely used as a food additive and major water disinfection by-product. It induces multiple organ toxicity in humans experimental animals probable human carcinogen. The present study reports the protective effect of dietary antioxidant taurine on KBrO3-induced damage to rat intestine. Animals were randomly divided into four groups: control, KBrO3 alone, alone taurine+ KBrO3. Administration led decrease activities intestinal brush border membrane enzymes while...

Cisplatin (CP) is a potent anti-cancer drug widely used against solid tumors. However, it exhibits pronounced adverse effects including hepatotoxicity. Several strategies were attempted to prevent CP hepatotoxicity but not found suitable for therapeutic application. Nigella sativa has been shown prevent/reduce the progression of certain type cardiovascular, kidney and liver diseases. Present study investigates whether N. oil (NSO) can induced hepatotoxic effects. Rats divided into four...

Industrialization and unchecked use of nitrate/nitrite salts for various purposes has increased human exposure to high levels sodium nitrite (NaNO2) which can act as a pro-oxidant pro-carcinogen. Oral makes the gastrointestinal tract particularly susceptible toxicity. In this work, effect administration single acute oral dose NaNO2 on rat intestine was studied. Animals were randomly divided into four groups given doses 20, 40, 60 75 mg NaNO2/kg body weight. Untreated animals served control...

The determination of the crystal structure muirite, Ba(10)(Ca,Mn,Ti)(4)Si(8)O(24)(Cl,OH,O)(12) . 4H(2)O, revealed presence discrete cyclic silicate anions, (Si(8)O(24))(16-), formed by condensation eight tetrahedra. This first reported occurrence eight-membered rings is particular interest, because with tetrahedra are to be energetically less stable than six tetrahedra, which have been found in many minerals.

Abstract: Curcumin (diferuloylmethane) is found in large quantities the roots of Curcuma longa. It possesses strong antioxidant and anti-inflammatory properties, inhibits chemically-induced carcinogenesis skin, forestomach, colon, liver. Unfortunately, poor bioavailability hydrophobicity curcumin pose a major hurdle to its use as potent anticancer agent. To circumvent some these problems, we developed novel, dual-core microcell formulation curcumin. The encapsulation microcells increases...

The crystal structure at room temperature and the low-temperature heat capacity magnetic susceptibilities of single crystals [${(\mathrm{C}{\mathrm{H}}_{3})}_{3}$ NH]Cu${\mathrm{Cl}}_{3}$ \ifmmode\cdot\else\textperiodcentered\fi{} 2${\mathrm{H}}_{2}$O are reported. monoclinic belong to space group $\frac{P{2}_{1}}{c}$ with $a=7.479(10)$ \AA{}, $b=7.864(11)$ $c=16.730(23)$ $\ensuremath{\beta}=91.98(3)\ifmmode^\circ\else\textdegree\fi{}$, $Z=4$. consists chains edge-sharing...

The in-house synthesized PLK-1 siRNA and cisplatin loaded innovative dendrimer-PLGA immuno-nanocomposite bears the capacity of delivering both cargos simultaneously to same liver cancer cell in a targeted manner.