A5001492621- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Vascular Tumors and Angiosarcomas
- Cervical Cancer and HPV Research
- Prenatal Screening and Diagnostics
- Histiocytic Disorders and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Plant Disease Resistance and Genetics
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Neonatal and fetal brain pathology
- Cancer Immunotherapy and Biomarkers
- Neurogenesis and neuroplasticity mechanisms
- T-cell and Retrovirus Studies
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Garlic and Onion Studies
- Pharmaceutical Practices and Patient Outcomes
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
Tongji Hospital
2023-2024
Huazhong University of Science and Technology
2017-2024
Shanxi Medical University
2011-2024
First Hospital of Shanxi Medical University
2011-2024
First Affiliated Hospital of Shihezi University Medical College
2024
Shihezi University
2010-2024
Binzhou University
2019-2024
Binzhou Medical University
2019-2024
Abstract The genus Allium is one of the largest monocotyledonous genera, containing over 850 species, and most these species are found in temperate climates Northern Hemisphere. Furthermore, as a large number new continue to be identified, phylogenetic classification based on morphological characteristics few genetic markers will gradually exhibit extremely low discriminatory power. In this study, we present use complete chloroplast genome sequences genome-scale studies . We sequenced...
Background: Anoectochilus roxburghii (Orchidaceae) is a traditional Chinese medicinal herb with anti-inflammatory, antilipemic, liver protective, immunomodulatory, and other pharmacological activities. Kinsenoside (KD), which shows protective effects against variety types of damage, an active ingredient extracted from A. . However, the potential mechanisms KD in alcoholic disease (ALD) remain unclear. This study aimed to investigate activity ALD. Methods: AML12 normal mouse hepatocyte cells...
Serum response factor (SRF) is important in muscle development, tissue repair, and neuronal regulation.
Background Cancer stem cells (CSCs) are proposed to be responsible for high recurrence rate in cervical carcinoma. Reagents that can suppress the proliferation and differentiation of CSCs would provide new opportunities fight against tumor recurrence. Doxycycline has been reported as a potential anti-cancer compound. However, few studies investigated its inhibitory effect cancer cells. Methods HeLa were cultured cell conditional media poly-hema-treated dish. In this non-adhesive culture...
Aggressive natural killer cell leukemia (ANKL) is a rare disease with an extremely aggressive clinical course. The etiology of ANKL unclear few genetic/epigenetic aberrations described to date. Moreover, misdiagnosis frequent problem. Clinicopathologic characteristics 35 retrospective cases were investigated the aim improving diagnosis and find associated etiology. Because relatively low number leukemic cells in peripheral blood bone marrow, can be missed; therefore, it important perform...
The gastrointestinal tract (GIT) is the most common anatomic site of extranodal non-Hodgkin lymphoma (NHL) involvement. classification criteria have changed in recent decades, and few large-sample studies regarding subtype analysis been performed this site.Therefore, present study was conducted to analyze histological distribution GIT.All patients a single institution with diagnosis primary NHL GIT were enrolled between January 2007 April 2014. categorized according WHO (2008) tumors...
Cell fate commitment in the developing CNS frequently depends on localized cell–cell interactions. In avian visual system optic nerve oligodendrocytes are derived from founder cells located at floor of third ventricle. Here we show that induction these is directly dependent signaling retinal ganglion cell (RGC) axons. The appearance oligodendrocyte precursor (OPCs) correlates with projection RGC axons, and early eye removal dramatically reduces number OPCs. vitro neurites induces OPCs...
Limited studies are available on the molecular pathogenesis of Epstein-Barr virus (EBV)-associated T or natural killer (NK) cell lymphoproliferative disorders (EBV+T/NK-LPD). In this retrospective study, we aim to elucidate mutation profile EBV+T/NK-LPD using capture-based targeted sequencing with a panel consisting 64 lymphoma-related genes identify driver associated development EBV+T/NK-LPD. Targeted 169 cases was performed genes. Of cases, 123 had extra-nodal NK/T-cell lymphoma (ENKTL),...
Cholestasis is an important predisposing factor of liver diseases, such as hepatocyte necrosis, fibrosis and primary biliary cirrhosis. In this study, we aimed to investigate the effects Kinsenoside (KD), a natural active ingredient Anoectochilus roxburghii, on estrogen-induced cholestatic injury in Sprague-Dawley rats underlying mechanism. The were randomly divided into six groups: control group, model low-dose KD group (50 mg/kg body weight, KD-L), medium-dose (100 KD-M), high-dose (200...
Carotenoid cleavage oxygenases (CCOs) are key enzymes that function in degrading carotenoids into a variety of apocarotenoids and some other compounds. In this study, we performed genome-wide identification characterization analysis CCO genes Cerasus humilis. Totally, nine could be classified six subfamilies, including carotenoid dioxygenase 1 (CCD1), CCD4, CCD7, CCD8, CCD-like nine-cis-epoxycarotenoid (NCED), were identified. Results gene expression showed ChCCOs exhibited diverse patterns...
Brain injury in preterm infants is a major cause of disability and mortality children. GSK-3β common pathogenic factor for cognitive dysfunction involves neuronal proliferation differentiation. However, affected differentiation its molecular pathogenesis after hypoxic-ischemic brain damage neonatal rats remains unclear. This study investigated the effects inhibitor (TWS119) on cell cycle regulatory proteins, (CEND1), maturation neurons, T-box transcription 1 (TBR1)-positive neurons to...
Manginoids A-G (1-7), seven monoterpene-shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1-4 are four isomers epimeric and double-bond isomeric features possessing 6-oxaspiro[bicyclo[3.2.1]octane-3,5'-indene] ring, which represent the first examples of bearing bridged spirocyclohexanedione moiety. 5 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.03,7]nonane motif, fuses 6-oxabicyclo[3.2.1]octane Compound 1 exhibits inhibitory...
Gastric cancer (GC) is one of the most frequent and lethal malignancies in world. However, our understanding mechanisms underlying its initiation progression limited. Here, we generate a series primary GC models mice with genome-edited gastric organoids, which elucidate genetic drivers for sequential transformation from dysplasia to well-differentiated poorly differentiated GC. Further, find that orthotopic GC, but not subcutaneous even same drivers, display remote metastasis, suggesting...
Abstract Aggressive natural killer cell leukemia/lymphoma (ANKL) is a rare aggressive form of NK-cell neoplasm. We report an uncommon case 36-year-old male who showed jaundice and spontaneous splenic rupture. The diagnosis was established by the biopsy liver spleen. monomorphous medium-size neoplastic cells infiltrated into portal areas sinus as well cords Necrosis, mitotic figures significant apoptosis could be seen easily. These demonstrated typical immunophenotype CD3ε+, CD56+, CD16+,...
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse lymphoma. Thirteen cases IVLBCL with median age 56 years were analyzed retrospectively. Nonspecific symptoms such as fever and hepatosplenomegaly the most common manifestations, bone marrow was usually involved in 8/13 (61.5%) cases. All tumors expressed CD20, 12/13 (92.3%) exhibited nongerminal center phenotype by Hans algorithm. CD5 3/12 (25%) tumors. MYC negative all cases, BCL2 positive 10/12 (83.3%) Cytogenetic...
Chronic active Epstein-Barr virus (EBV) infection of T-cell and NK-cell type, systemic form (CAEBV-T/NK-S) is characterized by EBV and/or proliferation with no changes suggesting malignancy. Therefore, when Hodgkin/Reed-Sternberg (HRS)-like cells are scattered in CAEBV-T/NK-S, it more likely to be misdiagnosed as classic Hodgkin lymphoma. We encountered a case wherein the patient showed HRS-like typical NK phenotype. we further investigated 8 similar cases provide clinicopathologic genetic...
Angiosarcoma of the breast is a high-grade malignant soft tissue tumor, it can be divided into primary and radiation-associated angiosarcoma(secondary). However, differences between secondary angiosarcomas in terms pathogenesis, clinical behavior, early diagnosis biomarkers, genetic abnormalities, therapeutic targets remain to fully elucidated. At same time, due its rarity, most current information relating angiosarcoma provided by case reports. Therefore, exploring mechanisms have important...
The appearance of smooth endoplasmic reticulum aggregation (SERa) is one the most common dysmorphic phenotypes oocytes, however, impact SERa occurrence on in vitro fertilization (IVF) outcomes controversial. This study aimed to investigate oocytes aneuploidy subsequent embryos IVF.In this retrospective cohort study, a total 114 intracytoplasmic sperm injection (ICSI) cycles with undergoing preimplantation genetic testing for (PGT-A) were enrolled, and among them there 323 SERa(+) 1253...