A5074780748- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Spinal Cord Injury Research
- Sarcoidosis and Beryllium Toxicity Research
- Mycobacterium research and diagnosis
- Autophagy in Disease and Therapy
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and Bioactive Compounds
- Kruppel-like factors research
- Lower Extremity Biomechanics and Pathologies
- Neurological Disorders and Treatments
- Signaling Pathways in Disease
- Cancer Genomics and Diagnostics
- Caveolin-1 and cellular processes
- Sarcoma Diagnosis and Treatment
- Phytochemical Studies and Bioactivities
- Colorectal and Anal Carcinomas
- Osteoarthritis Treatment and Mechanisms
- Medical Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Aortic Thrombus and Embolism
- Natural Antidiabetic Agents Studies
Wenzhou Medical University
2024
Binzhou University
2016-2024
Binzhou Medical University
2016-2024
Nanjing Medical University
2023
Aerospace Center Hospital
2023
Jiangsu Province Hospital
2023
Second Affiliated Hospital of Zhengzhou University
2018-2022
Sixth Affiliated Hospital of Sun Yat-sen University
2019-2020
Sun Yat-sen University
2019-2020
Shandong University
2019
Diabetic nephropathy (DN) is a prototypical chronic energy metabolism imbalance disease. The AMPK/Sirt1/PGC-1α signaling pathway plays pivotal role in regulating throughout the body. Gut microbiota ferment indigestible carbohydrates to produce variety of metabolites, particularly short-chain fatty acids (SCFAs), which exert positive effects on metabolism. However, potential for SCFAs ameliorate DN-associated renal injury via remains matter debate. In this study, we investigated sodium...
Metastasis is the primary cause of mortality in osteosarcoma. Targeting metastasis a major strategy osteosarcoma treatment. As traditional Chinese medicine, Trillium tschonoskii Maxim has been widely used therapy various diseases, including cancer. However, currently there no evidence regarding anti‑metastasic effect Paris saponin VII (PS VII), which extracted from Maxim, on cells and its underling mechanisms. The present study aimed to examine PS migration invasion cells. Viability...
Abstract Circular RNAs (circRNAs) are a newly discovered type of biological molecule that belongs to the noncoding RNA family. Abundant evidence has shown circRNAs involved in progression various cancers. However, particular functions colorectal cancer (CRC) remain elusive. In this study, we investigated differentially expressed three pairs tissue and adjacent normal CRC. We revealed circGLIS2 expression was higher CRC cell lines. Gain-and-loss function assays showed regulation migration....
Serum response factor (SRF) is important in muscle development, tissue repair, and neuronal regulation.
Abstract Purpose: Dysregulation of microRNAs (miRNAs) contributes to tumor progression via the regulation expression specific oncogenes and suppressor genes. One such example, miR-27b-3p, has reportedly been involved in many types cancer. The aim present study was delve into role underlying mechanism miR-27b-3p colorectal cancer (CRC) cells. Methods: In study, we detected level by RT-PCR. effect overexpression on cell proliferation CRC cells evaluated counting Edu assays. Transwell migration...
Wogonoside possesses anti-oxidative, anti-inflammatory, anti-allergy and anti-tumor properties. The aim of the present study was to evaluate whether wogonoside alleviates spinal cord injury (SCI)-induced inflammation via nuclear factor (NF)-κB nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation. Sprague-Dawley rats were positioned in jaws a calibrated aneurysm clip with closing pressure 55 g. placed on dorsal ventral...
The current investigation aimed to scrutinize the neuro-protective effect of hyperforin on β‑amyloid peptide (Aβ)1-42 and H2O2 induced injury in PC12 cells colchicine Alzheimer's disease (AD). were treated with presence hyperforin. cell viability was determined via suing MTT assay; malondialdehyde (MDA) lactate dehydrogenase (LDH) levels also scrutinized. Colchicine destruction memory learning which exhibited neurobehavioral theory (passive avoidance Morris water maze) connected reduced...
Therapeutic targeting of p53 has been implicated as a promising strategy for cancer treatment. MiRNAs are emerging important modulators invasion, regulation p53. Resent reports have shown that miR-150 is involved in the growth, invasion and metastasis numerous tumor types. However, role prostate pathology unclear. In this study, we firstly determined expression levels cell lines by quantitative real-time PCR (qRT-PCR). The effects on proliferation were evaluated using MTT, colony transwell...
Background. Minichromosome maintenance (MCM) genes are crucial for genomic DNA replication and important biomarkers in tumor biology. In this study, we aimed to identify the diagnostic, therapeutic, prognostic value of MCM2–10 patients with lung cancer. Methods. We examined expression levels, gene networks, protein networks cancer using data from ONCOMINE, GeneMANIA, STRING databases. conducted a functional enrichment analysis clusterProfiler package TCGA data. The correlation between...
Abstract Background To investigate the effect and underlying mechanism of umbilical cord blood-mononuclear cells (UCB-MNCs) in treating knee osteoarthritis (KOA) rabbits. Methods A rabbit KOA model was prepared by anterior cruciate ligament transection (ACLT). Fifty New Zealand white rabbits were randomly divided into control group, sodium hyaluronate (SH) platelet-rich plasma (PRP) group UCB-MNC group. Knee injections performed once a week for five consecutive weeks. The gross view joint,...
Objective To investigate the incidence of osteodystrophy induced by diving decompression in Yantai. Methods One hundred and seventy-one dive fishing personnel, who were hospitalized our hospital, selected as research subjects. Paranasal sinuses, both shoulders, hips knees had routine X-ray detection for study. Results Of all patients, 166 a history different degrees joint pain muscle pain. X-rays revealed that most divers suffering from decompressed...
Abstract Background The rituximab-related interstitial lung disease (RTX-ILD) is a serious adverse event in rituximab treatment patients. Krebs Von den Lungen-6 (KL-6) glycoprotein, which was suggested to be associated with injury and repair. Studies have shown that KL-6 can used as diagnostic biomarker for variety of diseases, while relevant researches are absent RTX-ILD. Objectives purpose this study evaluate the value serum levels detecting patients Methods 120 non-Hodgkin's lymphoma...
Objective To investigate the influence of Addie injection combined with R-CHOP chemotherapy on immune function and quality life in patients non-Hodgkin's lymphoma. Methods A total 76 lymphoma People's Hospital Wenzhou from June 2015 to March 2017 were selected randomly divided into control group study according digital table, 38 cases each group.The was treated chemotherapy, injection.After treatment, clinical efficacy, toxic side effects, indicators(CD3+ , CD4+ CD8+ /CD8+ ) life(KPS)...
Objective To investigate the clinical effect and safety of cell therapy inhibition antigen-presentation attenuators(iAPA) combined with adjuvant chemotherapy in treatment colon cancer. Methods From February 2014 to October 2015, data 40 patients cancer People's Hospital Wenzhou were analyzed retrospectively.They divided into control group study by random digital table, 20 cases each group.The received mFOLFOX6 chemotherapy(treatment for 6 months), was treated iAPA on basis (treatment...
Objective To evaluate the clinical efficacy of Butylphthalide combined with fibrinolytic enzyme in treatment acute cerebral infarction. Methods A total 60 elderly patients infarction who had missed opportunity thrombolytic therapy were enrolled this study from January 2014 to December 2016 at Zhengzhou University Second Affiliated Hospital.Patients randomly divided into an observation group(n=30)and a control group(n=30). Patients group treated alone, and those received enzyme.Peak...