A5100389849- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Genetic Mapping and Diversity in Plants and Animals
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- RNA Interference and Gene Delivery
- Insect Resistance and Genetics
- RNA Research and Splicing
- Insect-Plant Interactions and Control
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Myasthenia Gravis and Thymoma
- Insect symbiosis and bacterial influences
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Kruppel-like factors research
- Cancer-related gene regulation
- Meat and Animal Product Quality
- Viral Infectious Diseases and Gene Expression in Insects
- Adipokines, Inflammation, and Metabolic Diseases
Institute of Vegetables and Flowers
2017-2025
Chinese Academy of Agricultural Sciences
2017-2025
Northwest A&F University
2016-2025
Yangzhou University
2025
National Beef Cattle Industrial Technology System
2012-2024
Center for Life Sciences
2022-2024
Tsinghua University
2022-2024
Zhongnan Hospital of Wuhan University
2012-2024
Wuhan University
2012-2024
Shenzhen Center for Disease Control and Prevention
2024
Abstract BACKGROUND The whitefly Bemisia tabaci is a notorious agricultural pest known for its ability to cause significant crop damage through direct feeding and virus transmission. Its remarkable adaptability reproductive capacity are linked acquire integrate horizontally transferred genes (HTGs) into genome. These HTGs increase the physiological metabolic capacities of this pest, including cholesterol synthesis, which critical survival success. Among these genes, we identified...
Renal cell carcinoma (RCC) is one of the most frequently observed malignant tumours in urinary system and targeted drug resistance quite common RCC. Long noncoding RNA SNHG12 (lncRNA SNHG12) has emerged as a key molecule numerous human cancers, but its functions renal sunitinib remain unclear. In this study, we found was highly expressed RCC tissues sunitinib-resistant cells associated with poor clinical prognosis. promoted proliferation, migration, invasion via CDCA3 vitro. Mechanically,...
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by cells is major roadblock. We investigated whether quercetin, flavonoid, can sensitize human ovarian cancer TRAIL. Results indicate that quercetin sensitized The induced expression death receptor DR5 but did not affect DR4 cells. induction was mediated through activation JNK and upregulation transcription factor CCAAT enhancer-binding...
The bovine genetic resources in China are diverse, but their value and potential yet to be discovered. To determine the diversity population structure of Chinese cattle, we analyzed whole genomes 46 cattle from six phenotypically geographically representative breeds, together with 18 Red Angus genomes, 11 Japanese black taurine indicine available previous studies. Our results showed that originated hybridization between Bos taurus indicus. Moreover, found level variation depends upon degree...
Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway Cheng Gong,1 Zongyuan Yang,1 Lingyun Zhang,2 Yuehua Wang,2 Wei Gong,2 Yi Liu3 1Department Obstetrics Gynecology, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, 2Department Oncology, XiangYang Central Hubei Arts Science, XiangYang, 3Department Medicinal Chemistry, School Pharmacy, Chinese...
Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, chitin oligosaccharide (NACOS) displayed therapeutic effects on multiple diseases such as cancer gastritis. In this study, we aim confirm whether NACOS can ameliorate high-fat diet (HFD)-induced syndrome by rebuilding the structure of gut community. Male C57BL/6J mice fed with HFD were treated (1 mg/mL) in drinking water for five months. The results indicate that improved glucose...
Clear cell renal carcinoma (ccRCC) is the most common malignancy in adults, incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), was originally considered an RNA transcript, markedly expressed during adipocyte differentiation. In addition, it has been observed be elevated numerous types cancer, including ccRCC; however, its essential function remains unclear ccRCC. present study examined expression PLIN2 ccRCC, and aimed determine association between...
Mesenchymal stem cells (MSCs) are multipotent non-hematopoietic progenitor that can undergo self-renewal and differentiate into multi-lineages. Bone marrow stromal (BMSCs) represent one of the most commonly-used MSCs. In order to overcome technical challenge maintaining primary BMSCs in long-term culture, here we seek establish reversibly immortalized mouse (imBMSCs). By exploiting CRISPR/Cas9-based homology-directed-repair (HDR) mechanism, target SV40T Rosa26 locus efficiently immortalize...
Intramuscular fat (IMF) is closely related to the tenderness, marbling, juiciness, and flavor of meat. We used a combined transcriptome metabolome analysis investigate molecular mechanisms underlying phenotypic variation among Qinchuan cattle.The IMF content was relatively high in meat cattle bulls differed muscle locations, namely rib (15.86%), ribeye (14%), striploin (10.44%), tenderloin (8.67%). CCDC80 HOX gene cluster may regulate intramuscular adipose tissue deposition. Moreover, erucic...
There is an urgent need to make cisplatin (cDDP) more effective and less toxic in the treatment of ovarian cancer for its systemic side effects high resistance rate. In this study, we investigated effect quercetin (Qu) pretreatment on potentiation cDDP cancer. We found that Qu significantly enhanced cytotoxicity cell line primary cells. addition, demonstrated elicited obvious endoplasmic reticulum stress ( ERS ) activated all three branches Specific inhibitors each pathway, as well general...
In view of the poor prognosis laryngeal squamous cell carcinoma (LSCC) and functionality long non‑coding (lnc)RNA UCA1 in different types cancer, present study aimed to investigate role development progression LSCC. A total 90 patients with LSCC healthy subjects were enrolled study. Expression levels tumor tissues adjacent tissues, as well serum normal controls detected by reverse transcription‑quantitative polymerase chain reaction. Receiver operating characteristic curve analysis was...
Metastasis is the primary cause of mortality in osteosarcoma. Targeting metastasis a major strategy osteosarcoma treatment. As traditional Chinese medicine, Trillium tschonoskii Maxim has been widely used therapy various diseases, including cancer. However, currently there no evidence regarding anti‑metastasic effect Paris saponin VII (PS VII), which extracted from Maxim, on cells and its underling mechanisms. The present study aimed to examine PS migration invasion cells. Viability...
MicroRNAs are small, single stranded, and noncoding RNAs that have been proven to be potent regulators of adipogenesis. However, the role bta-miR-149-5p in regulating bovine adipogenesis is still unclear. Expression profiling different stages revealed was enriched proliferation stage, also on Day 9 differentiation adipocytes. Our gain function study showed can negatively regulate both adipocyte differentiation. Overexpression suppressed expression marker genes at messenger RNA (mRNA) protein...
Alginate oligosaccharide (AOS) holds great potential as a novel feed supplement in farm animals. However, the effects of AOS on chicken health and underlying mechanisms are not fully understood. This study aimed to optimize enzymatic preparation by using bacterial alginate lyases expressed yeast, investigate prepared growth performance gut broiler chickens, reveal mechanisms.Five from bacteria were cloned into Pichia pastoris GS115 lyase PDE9 was at relatively high yield, activity stability...
Nitrogen is an essential element for all life on earth. metabolism, including excretion, growth, development, and survival of plants animals alike. Several nitrogen metabolic processes have been described, but the underlying molecular mechanisms are unclear. Here, we reveal a unique process metabolism in whitefly Bemisia tabaci , global pest. We show that it has acquired two bacterial uricolytic enzyme genes, B. urea carboxylase ( BtUCA ) allophanate hydrolase BtAtzF ), through horizontal...
Abstract Background Indigenous Chinese cattle have abundant genetic diversity and a long history of artificial selection, giving local breeds advantages in adaptability, forage tolerance resistance. The detection selective sweeps comparative genome analysis selected ancestral populations provide basis for understanding differences among the identification utilization candidate genes. We investigated diversity, population structure, signatures selection using genome-wide sequencing data new...
Abstract The recent discovery that various insects have acquired functional genes through horizontal gene transfer (HGT) has prompted numerous studies into this puzzling and fascinating phenomenon. So far, horizontally transferred are found to be functionally conserved largely retained their ancestral functions. It evidently not yet been considered may evolve can contribute divergence between species. Here, it is first showed the genomes of two widespread agriculturally important whiteflies...