A5100737783- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Organ Transplantation Techniques and Outcomes
- Estrogen and related hormone effects
- Electrochemical Analysis and Applications
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Neuropeptides and Animal Physiology
- Nanomaterials for catalytic reactions
- Biliary and Gastrointestinal Fistulas
- Boron and Carbon Nanomaterials Research
- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
University of Science and Technology of China
1998-2025
Changzhou University
2024-2025
Second Affiliated Hospital of Zhengzhou University
2020-2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Union Hospital
2019-2023
Huazhong University of Science and Technology
2019-2023
Anhui Medical University
2011-2021
Stomatology Hospital
2021
Sun Yat-sen University
2011-2021
Abstract Objective Colorectal neoplasia differentially expressed ( CRNDE ), a vital cancer‐related long non‐coding RNA (lncRNA), has been brought to reports for playing quintessential functions in the growth and progression of several human malignancies. Nevertheless, expression as well functional mechanisms pancreatic cancer is not known so for. This study aimed at investigating biological clinical importance cancer. Materials methods The levels tissues cell lines were identified with help...
Renal cell carcinoma (RCC) is one of the most frequently observed malignant tumours in urinary system and targeted drug resistance quite common RCC. Long noncoding RNA SNHG12 (lncRNA SNHG12) has emerged as a key molecule numerous human cancers, but its functions renal sunitinib remain unclear. In this study, we found was highly expressed RCC tissues sunitinib-resistant cells associated with poor clinical prognosis. promoted proliferation, migration, invasion via CDCA3 vitro. Mechanically,...
This study analyzes temporal trends of pancreatitis from 1990 to 2021 across 21 regions and 204 countries based on the Global Burden Disease (GBD) database inform prevention treatment strategies. Incidence, death, prevalence, DALYs estimates for were derived GBD 2021, categorized by age, sex, geographical location period 1990-2021. Mortality generated using cause death ensemble model. The global age-standardized incidence deaths increased 1.59-fold 1.79-fold respectively. percentage change...
Revascularization is an effective therapy for rescuing myocardial tissue after ischemic events. However, the process of reperfusion can lead to more severe cardiomyocyte damage, called ischemia‐reperfusion (I/R) injury (MIRI). We have previously shown that vitexin (VT) (a flavonoid compound derived from natural products) protects against MIRI; however, exact mechanisms underpinning this effect require further elucidation. This study aimed at elucidating protective mechanism VT in inhibiting...
Triple-negative breast cancer (TNBC) is a type of with high degree malignancy. Because the remarkable biological characteristics invasion, metastasis and recurrence, TNBC often accompanied by poor prognosis. As molecular characteristic TNBC, expression CD147 has been confirmed large number studies. However, mechanism regulation in remains elusive. In this study, we investigated roles miR-890 inhibiting CD147.Quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) was used to...
BACKGROUNDS: Previous studies have showed that long non-coding RNAs (lncRNAs) are critical regulators in many cancers. The aim of this study is to investigate the clinical role and functional effects RNA SNHG14 pancreatic ductal
Recently long non-coding RNAs (lncRNAs) have emerged as novel gene regulators involved in tumorigenic processes, including oral squamous cell carcinoma (OSCC). Here, we identified a differentiation-related lncRNA, terminal differentiation-induced RNA (TINCR). However, its biological function and clinicopathological significance OSCC still remain unclear.The lncRNA expression profiles tissues paired adjacent non-tumor (NATs) from 10 patients were detected by microarrays. Weighted...
Mounting evidence indicates that there exists an association between heparanase (HPSE) and several physiological pathological mechanisms in humans. However, the dynamics of involved regulation HPSE expression pancreatic cancer (PC) remain unclear. The aim present study was to assess levels PC tissues cell lines by western blotting reverse transcription‑quantitative PCR (RT‑qPCR) analysis. Wound healing Transwell assays were conducted examine effects on migration invasion sh‑NC sh‑HPSE lines....
Accumulating evidence has suggested that long non-coding (lnc)RNAs are widely involved in the progression of multiple diseases, including chronic obstructive pulmonary disease (COPD). The aim present study was to explore function and molecule mechanism maternally expressed gene 3 (MEG3) cigarette smoke extract (CSE)-treated 16HBE cells. Cell viability apoptosis were evaluated using Counting Kit-8 analysis flow cytometry, respectively. Western blot carried out determine protein levels Bcl-2,...
BACKGROUND:Latent transforming growth factor b binding protein 2 (LTBP2) is proven to be associated with ECM and involved in the advancement of several kinds cancer. The present study evaluated diagnosis prognosis pancreatic carcinoma (PC) using LTBP2 as a biomarker. MATERIAL AND METHODS:Protein levels were 111 pairs ductal adenocarcinoma (PDAC) tissues adjacent nontumor via immunohistochemistry. ELISA method was used quantify serum concentration LTBP2. subjects this included 141 PDAC...
Clear cell renal carcinoma (ccRCC) is one of the most common malignant tumors urinary system and has a poor response to radiotherapy chemotherapy.To date, it urgent find effective biomarkers for prevention treatment ccRCC.The occurrence development ccRCC closely related metabolic disturbances.Palmitoyl protein thioesterase 2 (PPT2) lysosomal which highly associated with metabolism, never been studied in ccRCC.In this study, we first revealed PPT2 significantly downregulated ccRCC, its...
The present study aimed to investigate the effect and mechanism of γ-aminobutyric acid (GABA) on bio-nomics cholangiocarcinoma QBC939 cells. A transwell cell culture chamber assay in vitro was used detect ability invasion metastasis expression matrix metalloproteinase (MMP) mRNA enzymatic activity cells were detected by reverse transcription-polymerase chain reaction gelatin zymography, respectively. Different concentrations GABA inhibited tumor trans-Matrigel migration (100 μmol/l GABA,...
// Tengyue Zhang 1, 2, * , Kelong Ma 3, Jin Huang Shitang Wang 4, Yabei Liu 2 Gaofei Fan Miao Guangshan Yang Cheng 4 and Pingsheng 1 School of Clinical Medicine, Shan Dong University, Jinan 250100, China The Cancer Hospital Anhui Province, Provincial Medical Hefei 230032, 3 College Integrated Traditional Chinese Western University Department General Surgery, These authors have contributed equally to this work Correspondence to: Fan, email: wangal2014@sohu.com Wang, blackpippy@163.com...
There is a growing number of evidence which report the relationship dual-specificity phosphatases 14 (DUSP14) with physiological and pathological mechanisms in human body. However, it still not known what if any role DUSP14 plays pancreatic cancer.The study evaluates levels cancer tissues cell lines using Western blotting qRT-PCR to assess epithelial-mesenchymal transition (EMT) biomarkers. After was blocked, following assays were performed: colony formation, assessments scratch wound...