A5100442129- Chromosomal and Genetic Variations
- Prostate Cancer Treatment and Research
- Plant Disease Resistance and Genetics
- Plant tissue culture and regeneration
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Plant Reproductive Biology
- Cancer, Hypoxia, and Metabolism
- Plant Virus Research Studies
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Advancements in Battery Materials
- Plant Pathogens and Resistance
- Mass Spectrometry Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related gene regulation
- RNA modifications and cancer
- Advanced Battery Materials and Technologies
- Plant Genetic and Mutation Studies
- MicroRNA in disease regulation
- Supercapacitor Materials and Fabrication
Inner Mongolia University
2014-2025
Third Affiliated Hospital of Sun Yat-sen University
2015-2025
Sun Yat-sen University
2015-2025
Zhuhai Institute of Advanced Technology
2025
Beijing Institute of Technology
2025
Huazhong University of Science and Technology
2005-2024
Union Hospital
2014-2024
China Southern Power Grid (China)
2024
Southwest University
2023-2024
China Railway Group (China)
2023
Polyploidy has contributed to the evolution of eukaryotes, particularly flowering plants. The genomic consequences polyploidy have been extensively studied, but mechanisms for chromosome stability and diploidization in polyploids remain largely unknown. By using new cytogenetic tools identify all homoeologous chromosomes, we conducted a cytological investigation 50 resynthesized Brassica napus allopolyploids across generations S 0:1 5:6 10:11 generation. Changes copy number individual...
There is increasing evidence that circular RNA (circRNA) are involved in cancer development, but the regulation and function of human circRNA remain largely unknown. In this study, we demonstrated ZKSCAN1, a zinc finger family gene, expressed both linear (circZKSCAN1) forms hepatocellular carcinoma (HCC) tissues cell lines. Here, analyzed cohort 102 patients found expression ZKSCAN1mRNA circZKSCAN1 was significantly lower (P < 0.05) HCC samples compared with matched adjacent nontumorous by...
Although draft genomes are available for most agronomically important plant species, the majority incomplete, highly fragmented, and often riddled with assembly scaffolding errors. These issues hinder advances in tool development functional genomics systems biology.Here we utilized a robust, cost-effective approach to produce high-quality reference genomes. We report near-complete genome of diploid woodland strawberry (Fragaria vesca) using single-molecule real-time sequencing from Pacific...
Highbush blueberry (Vaccinium corymbosum) has long been consumed for its unique flavor and composition of health-promoting phytonutrients. However, breeding efforts to improve fruit quality in have greatly hampered by the lack adequate genomic resources a limited understanding underlying genetics encoding key traits. The genome highbush particularly challenging assemble due, large part, polyploid nature size.
Abstract Tumor‐associated macrophage (TAM) infiltration facilitates glioma malignancy, but the underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal LINC01232 to induce tumor immune escape. Mechanistically, found directly bind E2F2 and promote entry into nucleus; two synergistically promots transcription of NBR1. The increase in binding between NBR1 ubiquitinating MHC‐I protein through ubiquitin domain causes an degradation autophagolysosomes a decrease...
Background Polyploidy, frequently termed “whole genome duplication”, is a major force in the evolution of many eukaryotes. Indeed, most angiosperm species have undergone at least one round polyploidy their evolutionary history. Despite enormous progress our understanding aspects polyploidy, we essentially no information about role chromosome divergence establishment young polyploid populations. Here investigate synthetic lines and natural populations two recently recurrently formed...
Renal cell carcinoma (RCC) is one of the most frequently observed malignant tumours in urinary system and targeted drug resistance quite common RCC. Long noncoding RNA SNHG12 (lncRNA SNHG12) has emerged as a key molecule numerous human cancers, but its functions renal sunitinib remain unclear. In this study, we found was highly expressed RCC tissues sunitinib-resistant cells associated with poor clinical prognosis. promoted proliferation, migration, invasion via CDCA3 vitro. Mechanically,...
High accumulation of hyaluronan (HA) in the tumor microenvironment leads to an increase interstitial pressure and reduction perfusion drugs. Furthermore, high molecular-weight (HMW)-HA suppresses M1 macrophage polarization, enhances M2 induces immunosuppression. Hyaluronidase treatment have attempted decrease quantity HA tumors. However, hyaluronidase-driven degradation driven accelerates cell metastasis, which is a major cause mortality cancer patients. Thus, we designed novel exosome-based...
Allopolyploidisation merges evolutionarily distinct parental genomes (subgenomes) into a single nucleus. A frequent observation is that one subgenome 'dominant' over the other subgenome, often being more highly expressed. Here, we 'replayed evolutionary tape' with six isogenic resynthesised Brassica napus allopolyploid lines and investigated dominance patterns first 10 generations postpolyploidisation. We found same was consistently dominantly expressed in all >70% of biased gene pairs...
Polyploidy is a major evolutionary force that has shaped plant diversity. However, the various pathways toward polyploid formation and interploidy gene flow remain poorly understood. Here, we demonstrated immediate progeny of allotriploid AAC Brassica (obtained by crossing allotetraploid napus diploid rapa ) was predominantly aneuploids with ploidal levels ranging from near-triploidy to near-hexaploidy, their chromosome numbers deviated theoretical distribution increasing numbers, suggesting...
Investigating recombination of homoeologous chromosomes in allopolyploid species is central to understanding plant breeding and evolution. However, examining chromosome pairing the allotetraploid Brassica napus has been hampered by lack chromosome-specific molecular probes. In this study, we establish identification all B. using robust cytogenetic karyotypes developed for progenitor rapa (A genome) oleracea (C genome). The every among these three utilized genetically mapped bacterial...
PREMISE OF THE STUDY Previous phylogenetic studies employing molecular markers have yielded various insights into the evolutionary history across Brassicales, but many relationships between families remain poorly supported or unresolved. A recent phylotranscriptomic approach utilizing 1155 nuclear obtained robust estimates for among 14 of 17 families. Here we report a complete family‐level phylogeny estimated using plastid genome. METHODS We conducted analyses on concatenated data set...
Long noncoding RNAs (lncRNAs), such as LINC00462, HOTAIR, and MALAT1, are significantly upregulated in hepatocellular carcinoma (HCC) tissues.However, lncRNA expression the serum of HCC patients is still unclear.To identify candidate lncRNAs for diagnosis, we purified exosomal total RNA from healthy volunteers (controls) hepatitis, cirrhosis, patients.To assess function lncRNAs, small interfering overexpression vectors were designed cell viability apoptosis assays conducted.The exosomes...
Abstract Background Clear cell renal carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the importance autophagy in ccRCC has been focused, it potential connections with HIF-2α metabolism. However, specific regulatory mechanism between HIF-2α, autophagy, still unclear. Methods In this study, Bioinformatics Analysis Sequencing whole transcriptome were used to screen our target. The expression TBC1D5 clear was confirmed by database analysis,...
Manganese-based oxides, with a variety of oxidation states and crystal structures, are treated to be one the most brilliant zinc storage cathode materials in aqueous ion batteries (AZIBs)....
Resistance to lenvatinib limits the effectiveness of targeted treatments for HCC. However, exact mechanism behind this resistance remains elusive. Current research suggests that circular RNA (circRNA) is pivotal in mediating drug during treatments. To investigate influence circRNA on HCC progression and its lenvatinib. We identified crucial hsa_circ_0005711 (circPIK3C3) through bioinformatics. Study (in-vitro in-vivo) expression circPIK3C3 (measured by qRT-PCR) association with progress...
With the rapid development of Artificial Intelligence Generated Content (AIGC) technology, education is undergoing profound changes. AIGC significantly promotes inclusiveness, equity and quality by providing personalised learning content intelligent instructional support to tailor experience for students, which aligns with United Nations 2030 Sustainable Development Goals (SDG4) requirements on sustainability education. However, despite great potential in education, its practical application...
The genomes of allopolyploids newly formed through hybridization and polyploidization exhibit substantial changes including those at genetic epigenetic levels. These alterations may affect their gene expression patterns, leading to nonadditive expression. Currently, only a few reports are available on the impact expressions traits. Using six isogenic resynthesized Brassica napus lines across first 10 generations, we studied patterns flowering time. levels group genes, located chromosome A09,...