Yafen Gao

ORCID: 0000-0001-5315-2073
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About
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Research Areas
  • Autophagy in Disease and Therapy
  • Cancer, Hypoxia, and Metabolism
  • Cancer, Lipids, and Metabolism
  • Sirtuins and Resveratrol in Medicine
  • Urinary Bladder and Prostate Research
  • Organ Transplantation Techniques and Outcomes
  • Cardiovascular Disease and Adiposity
  • Receptor Mechanisms and Signaling
  • Nausea and vomiting management
  • Venous Thromboembolism Diagnosis and Management
  • Bladder and Urothelial Cancer Treatments
  • Urinary and Genital Oncology Studies
  • Anesthesia and Sedative Agents
  • Cardiac Ischemia and Reperfusion
  • Sleep and Wakefulness Research
  • Ultrasound and Hyperthermia Applications
  • Metabolism, Diabetes, and Cancer
  • Neuroscience and Neuropharmacology Research
  • Immune Response and Inflammation
  • Cardiac and Coronary Surgery Techniques
  • Nerve Injury and Rehabilitation
  • Fatty Acid Research and Health
  • Eicosanoids and Hypertension Pharmacology
  • Mitochondrial Function and Pathology
  • Botulinum Toxin and Related Neurological Disorders

Union Hospital
2024

Huazhong University of Science and Technology
2021-2024

Union Hospital
2021-2024

Wenzhou Medical University
2022

Beijing Anzhen Hospital
2018-2020

Capital Medical University
2018-2020

Autophagy caused by ischemia/reperfusion (I/R) increases the extent of cardiomyocyte damage. Melatonin (Mel) diminishes cardiac injury through regulating autophagy and mitochondrial dynamics. However, illustrating specific role mitophagy in cardioprotective effects melatonin remains a challenge. The aim our research was to investigate impact underlying mechanisms connection with during anoxia/reoxygenation (A/R) H9c2 cells.H9c2 cells were pretreated or without membrane receptor 2 (MT2)...

10.2147/dddt.s248628 article EN cc-by-nc Drug Design Development and Therapy 2020-05-01

Abstract Background Clear cell renal carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the importance autophagy in ccRCC has been focused, it potential connections with HIF-2α metabolism. However, specific regulatory mechanism between HIF-2α, autophagy, still unclear. Methods In this study, Bioinformatics Analysis Sequencing whole transcriptome were used to screen our target. The expression TBC1D5 clear was confirmed by database analysis,...

10.1186/s12967-024-05015-y article EN cc-by Journal of Translational Medicine 2024-02-28

Data on the efficacy and incidence of adverse effects associated with dexmedetomidine (DEX) as a local anesthetic adjuvant for patient-controlled epidural analgesia (PCEA) are inconclusive. This meta-analysis assessed risks DEX PCEA using opioids reference.

10.4097/kja.22730 article EN cc-by-nc Korean journal of anesthesiology 2023-05-02

Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT safe hyperlipidemic population for long-term use. Free fatty acids (FFAs) were establish high-fat stimulation of HepG2 Huh7 cells. Subsequently, these cells treated with at concentration 0, 4, or 8 µg/ml 24 48 h. results indicated that cell viability was notably decreased when stimulated 2 mmol/L FFAs 12...

10.4196/kjpp.2020.24.1.19 article EN Korean Journal of Physiology and Pharmacology 2020-01-01

Gastric carcinoma (GC) is a common lethal cancer in the world. Patients are prone to develop lower extremity deep venous thrombosis (LEDVT) after laparoscopic radical gastrectomy (LRG), which threatens their life and health.This research clarify preventive action of rivaroxaban (Riv) against LEDVT patients undergoing LRG.A retrospective study was conducted on 70 with GC admitted for LRG between January 2019 2022, including 40 (observation group) receiving Riv treatment 30 (conventional...

10.1155/2022/7140066 article EN Computational and Mathematical Methods in Medicine 2022-09-10
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