A5067017092- Circular RNAs in diseases
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Statistical Methods in Clinical Trials
- Hepatitis B Virus Studies
- Liver physiology and pathology
- RNA modifications and cancer
- Nitrogen and Sulfur Effects on Brassica
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
Third Affiliated Hospital of Sun Yat-sen University
2022-2025
Sun Yat-sen University
2022-2025
Resistance to lenvatinib limits the effectiveness of targeted treatments for HCC. However, exact mechanism behind this resistance remains elusive. Current research suggests that circular RNA (circRNA) is pivotal in mediating drug during treatments. To investigate influence circRNA on HCC progression and its lenvatinib. We identified crucial hsa_circ_0005711 (circPIK3C3) through bioinformatics. Study (in-vitro in-vivo) expression circPIK3C3 (measured by qRT-PCR) association with progress...
Long non-coding RNAs have been reported to play a crucial role in tumor progression hepatocellular carcinoma (HCC).Lnc-ZEB2-19 has validated be deficiently expressed HCC.However, the capabilities and underlying mechanisms of lnc-ZEB2-19 remain uncertain.In this study, we verified that downregulation was prevalent HCC significantly correlated with unfavorable prognosis.Further vitro vivo notably inhibited proliferation, metastasis, stemness, lenvatinib resistance (LR) cells.Mechanistically,...
Abstract Circular RNAs (circRNAs) are crucial regulators of targeted drug resistance in hepatocellular carcinoma (HCC). However, the specific mechanisms underlying that significantly hampers effectiveness HCC treatments remain unclear. Here, it is found circRNA‐mTOR highly expressed and strongly correlated with patient prognosis. Furthermore, enhances stemness cells, thereby promoting progression contributing to lenvatinib resistance. Mechanistically, promotes nuclear translocation...
Circular RNAs (circRNAs) are important for the process of cancer initiation and progression. However, role circRNAs in hepatocellular carcinoma (HCC) remains incompletely understood. Therefore, we further explored expression network HCC.Whole-transcriptome microarrays HCC paired normal liver tissues were obtained from Gene Expression Omnibus (GEO) database. The structures tumor-associated acquired by Cancer-Specific CircRNA Database (CSCD). StarBase, circBank, R packages (miRNAtap multiMiR)...
Abstract Background Hepatocellular Carcinoma (HCC) is one of the major malignant tumors threatening human health. Lenvatinib resistance seriously restricts efficacy HCC, but specific mechanism not clear. Circular RNA (circRNA) plays an important role in regulation tumor drug resistance. Methods Key circRNA was screened by bioinformatics methods, and further identified relevant validation experiments HCC tissue samples. And, evaluated as a diagnostic prognostic marker for progression at...
<sec><b>Objective</b>Unresectable hepatocellular carcinoma (uHCC) continues to pose effective treatment options. The objective of this study was assess the efficacy and safety combining low-dose cyclophosphamide with lenvatinib, pembrolizumab transarterial chemoembolization (TACE) for uHCC. </sec><sec><b>Methods</b>From February 2022 November 2023, a total 40 patients diagnosed uHCC were enrolled in small-dose, single-center, single-arm, prospective study. They received combined...