A5045952082- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Cardiac tumors and thrombi
- Mast cells and histamine
- Intraperitoneal and Appendiceal Malignancies
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Liver Disease and Transplantation
University of Science and Technology of China
2018-2023
Chinese Academy of Sciences
2023
Shandong University
2022
Anhui Provincial Hospital
2005-2021
Anhui Medical University
2013-2019
Heritage Christian University
2003
Abstract Suberoylanilide hydroxamic acid (SAHA) is a well-known histone deacetylase (HDAC) inhibitor and has been used as practical therapy for breast cancer non-small cell lung (NSCLC). It previously demonstrated that SAHA treatment could extensively change the profile of acetylome proteome in cells. However, little known about impact on other protein modifications crosstalks among different proteome, hindering deep understanding SAHA-mediated therapy. In this work, by using SILAC...
Lysine crotonylation is a newly discovered protein post-translational modification and was reported to share transferases deacylases with lysine acetylation. The acetyltransferase p300 also contain crotonyltransferase activity, class I histone deacetylases were demonstrated be the major decrotonylases. However, decrotonylases for nonhistone proteins are unclear. Moreover, because of lack high-quality pan-antibodies, large-scale analysis crotonylome still remains challenge. In this work, we...
Colorectal carcinoma (CRC) is a major cause of cancer mortality. The aberrant expression several microRNAs associated with CRC progression; however, the molecular mechanisms underlying this phenomenon are unclear. miR-638 and SRY-box 2 (SOX2) levels were detected in 36 tumor samples their adjacent, non-tumor tissues from patients CRC, as well 4 cell lines, using real-time quantitative RT-PCR (qRT-PCR). SOX2 90 adjacent tissue immunohistochemistry. Luciferase reporter Western blot assays used...
Lysine 2-hydroxyisobutyrylation is a newly discovered protein acylation and was reported to share acyltransferases deacylases with the widely studied lysine acetylation. The well-known acetyltransferase Tip60 histone deacetylases HDAC 2 3 were be "writer" "eraser" of this new PTM on histones. However, for nonhistone proteins are still unclear. In work, 2-hydroxyisobutyrylome both histones upon SAHA treatment intensively 8765 sites 2484 identified in A549 cells. This largest data set...
Abstract Background Cell pyroptosis has been characterized by cell swelling and pro-inflammatory factors release to aggravate inflammatory reaction., such as interlukin-1 beta (IL-1β) interlukin18 (IL-18). However, the function of famotidine, an antagonist histamine H2-receptor antagonists, in remained unknown. Methods Real-time quantitative PCR (qPCR), western blotting (WB), LDH assay enzyme linked immunosorbent (Elisa) combined with inhibitor were performed analyze effect famotidine on...
This study evaluates the clinical effectiveness of targeted arterial infusion verapamil in interventional treatment primary hepatocellular carcinoma. For this purpose, 273 patients with middle- or late-stage carcinoma, verapamil, IL-2, and chemotherapeutic agents were infused into target tumor vasculature through femoral artery using Seldinger technique. The medications as serial dilutions, was evaluated after two cycles. Among these patients, 76 cases showed cure significant improvement,...
To assess the clinical efficacy of targeted arterial perfusion verapamil and chemotherapeutic agents in interventional therapy lung cancer.Forty patients with advanced cancer underwent treatment using Seldinger technique. Interventional was performed once a month, each subject received for 2 or more cycles. The therapeutic evaluated months post-treatment.Out 40 cancer, 5 cases achieved complete remission (CR) 29 partial (PR), total effectiveness (CR + PR) rate 85 %. Besides, 32 significantly...
Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played vital role in Epithelial-Mesenchymal Transition (EMT) gastric cancer. However, REC8 cancer remains to be identified.Inhibition expression cells contributed microenvironment. The clinical analysis demonstrated loss with enrichment MVD. Depletion significantly increased tube formation human umbilical vein endothelial (HUVECs), which...
BACKGROUND. Targeted arterial infusion of verapamil combined with chemotherapy (TVCC) is an effective clinical interventional therapy for esophageal squamous cell carcinoma (ESCC), but multidrug resistance (MDR) remains the major cause relapse or poor prognosis, and underlying molecular mechanisms MDR, temporal intratumoral heterogeneity, clonal evolutionary processes have not been determined.
// Tengyue Zhang 1, 2, * , Kelong Ma 3, Jin Huang Shitang Wang 4, Yabei Liu 2 Gaofei Fan Miao Guangshan Yang Cheng 4 and Pingsheng 1 School of Clinical Medicine, Shan Dong University, Jinan 250100, China The Cancer Hospital Anhui Province, Provincial Medical Hefei 230032, 3 College Integrated Traditional Chinese Western University Department General Surgery, These authors have contributed equally to this work Correspondence to: Fan, email: wangal2014@sohu.com Wang, blackpippy@163.com...
BACKGROUND:The aim of this study was to investigate the role ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in reversal effect verapamil (VER) on chemo-resistance Adriamycin (ADM) treatment hepatocellular carcinoma (HCC). MATERIAL AND METHODS:HCC cell lines SMMC-7721 and BEL-7402 were used as model lines. High-throughput transcriptome sequencing based Illumina technology screen whether UCHL1 mediated VER chemo-resistance. Quantitative real-time PCR (qRT-PCR) performed determine expression...
In patients with esophageal carcinoma, local immune suppression and the expression of soluble immunosuppressive factors have been observed. We aimed to investigate correlation between level CD4+CD25high regulatory T (Treg) cell outcome chemotherapy in advanced carcinoma.Forty-eight cases carcinoma were enrolled from June 2006 December 2008. CD3+CD8+ cell, CD3+CD4 CD4+CD25+ Treg NK determined before after chemotherapy. After two cycles chemotherapy, its effect was evaluated survival time...
Objective: To explore the efficacy and safety of polyethylene glycal recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in preventing chemotherapy-induced neutropenia patiens with breast cancer. Methods: There were two parts present phase Ⅳ clinical study. One was a randomized, controlled Patients this study received PEG-rhG-CSF or rhG-CSF first cycle followed both rest 3 cycles. The other one single arm who developed Ⅲ/Ⅳ grade screening cycles chemotherapy. Results: In...
Background: This study aimed to investigate the clinical efficacy of target artery perfusion verapamil combined with chemotherapy in treating esophageal cancer (EC).Methods: A total 46 patients EC (stage III and IV) were treated via infusion. Two four courses per month treatment administrated. Imaging modalities used staging before after include gastroscopy/endoscopic ultrasonography, computed tomography (CT) 64-detector-row gemstone spectral imaging/3.0-T magnetic resonance imaging (MRI)....
Background: Afatinib is a second-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) that has been approved by the Food and Drug Administration for treatment of advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations. We performed meta-analysis to assess efficacy safety afatinib in NSCLC. Methods: searched PubMed, PMC database, EMBASE, Cochrane Library Web Science obtain relevant literature. The was assessed based on progression-free survival (PFS),...