A5101526878- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Colorectal and Anal Carcinomas
- Mesenchymal stem cell research
- Colorectal Cancer Surgical Treatments
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Folate and B Vitamins Research
- MicroRNA in disease regulation
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Diverticular Disease and Complications
- Liver Disease and Transplantation
- Intraperitoneal and Appendiceal Malignancies
- Venomous Animal Envenomation and Studies
- Biochemical and Structural Characterization
- Metabolism and Genetic Disorders
- Lipid Membrane Structure and Behavior
- Cancer survivorship and care
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism, Diabetes, and Cancer
- Maternal Mental Health During Pregnancy and Postpartum
Hainan University
2025
University of Science and Technology of China
2003-2024
Capital Institute of Pediatrics
2014-2022
Beijing YouAn Hospital
2022
Capital Medical University
2022
Anhui Medical University
2013-2021
Anhui Provincial Hospital
2015-2021
First Affiliated Hospital of Zhengzhou University
2015
University of Pennsylvania
2013
Chinese Academy of Sciences
2003
AIMTo determine whether circular RNAs (circRNAs) are involved in pathological processes of gastric cancer (GC). METHODSThree circRNAs with differential expression GC and colorectal were randomly selected for validation by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), using 20 pairs tissues normal tissues.Based on the predicted circRNA-miRNA network, we then focused hsa_circ_0000745, which was found to be down-regulated compared tissues.The hsa_circ_0000745
Abstract Background: Maternal oxidative stress during pregnancy plays as hazardous factor of offspring neurodevelopment in animal models. However, epidemiological evidence remains limited. In this prospective cohort, we aimed to investigate the associations between maternal biomarkers across and neurodevelopmental outcomes different stages early childhood. Methods: This is a cohort study conducted 1791 mother-child pairs from Wuhan, China. Three biomarkers, including DNA biomarker...
Aim . To evaluate the impact of preoperative anemia (POA) on perioperative outcomes in patients undergoing elective surgery for colorectal cancer (CRC). Methods A total 326 CRC were enrolled. POA was defined as a hemoglobin (Hb) concentration ≤ 12 g/dl. Univariable and multivariable analyses performed to assess risks postoperative complications like surgical site infection (SSI). Results Patients with colon presented higher rate than rectal (60% versus 40% cancer). In addition, female large...
This study detected the expression level of IL-1β in gastric cancer tissue and paracarcinoma tissue, also analyzed its relationship with clinical pathological features, so as to explore effect on cancer. A total 70 fresh primary tumors corresponding tissues away from tumor-incision edge (≥5 cm) were selected First Affiliated Hospital Zhengzhou University January December 2014. Total protein concentration was extracted radioimmunoprecipitation assay lysis buffer, content enzyme-linked...
Adipose-derived mesenchymal stem cells (ADMSCs) have been used for treating tissue injury, and preactivation enhances their therapeutic effect. This study is aimed at investigating the effect of activated ADMSCs by IL-1β on intestinal ischaemia-reperfusion (IR) injury exploring potential mechanisms. were pretreated with in vitro, activation was assessed α-SMA COX-2 expressions secretary function. Activated transplanted into IR-injured intestine a mouse model, evaluated. In addition, to...
Recruitment of immune cells to tumor targeted by a therapeutic antibody can heighten the antitumor efficacy antibody. For example, p185(her2/neu)-targeting antibodies not only downregulate p185(her2/neu) kinase (ERBB2) but also trigger complement-dependent cytotoxicity (CDC) and antibody-dependent cellular (ADCC) through Fc region. Here, we describe generalized strategy improve cell recruitment cancer cells, using modified scFv call "Grababody" that binds target protein endogenous...
Abstract Background This study aimed to compare low Hartmann’s procedure (LHP) with abdominoperineal resection (APR) for rectal cancer (RC) regarding postoperative complications. Method RC patients receiving radical LHP or APR from 2015 2019 in our center were retrospectively enrolled. Patients’ demographic and surgical information was collected analyzed. Propensity score matching (PSM) used balance the baseline information. The primary outcome incidence of major All statistical analysis...
AaH-IV, a P-III-type metalloproteinase found in Agkistrodon acutus venom, readily cleaves itself to release stable protein named acucetin at 310 K under neutral and weakly alkaline conditions. A partial amino-acid residue sequence of indicates that the has high homology snake-venom proteins containing both disintegrin-like cysteine-rich domains. Acucetin been crystallized space group R32, with hexagonal unit-cell parameters = b 155.98, c 76.07 Å. The VM value about 2.97 Å3 Da−1 suggests...
Objective To investigate the characteristics and mechanism of dynamics HBV infection with progression HIV disease to explore different responses T lymphocytes in patients stages disease. Methods We compared rates coinfection between 372 early HIV-infected 306 chronically men who have sex (MSM) Beijing Youan Hospital from October 2006 November 2014. further analysed IFN-γ-producing HBV-specific CD8+ cells 15 individuals 20 chronic coinfection. Results Twenty-three HBsAg-positive cases were...
Laparoscopic radical gastrectomy has been increasingly applied in China. However, how to reduce surgery-related trauma, shorten operative time and achieve the long-term prognosis equal conventional open surgery is still hot research topics. Along with change learning curve optimization of endoscopic techniques, laparoscopic lymph node dissection can or even exceed extent that be achieved surgery. Therefore, it gradually replaced digestive tract reconstruction using an auxiliary incision. By...
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Laparoscopic resection for rectal cancer has been gaining popularity over the past 2 decades. Whether elderly patients had more benefits from laparoscopy-assisted anterior (LAR) need further investigation when comparing with open (OAR).This study aimed to evaluate clinical outcomes and prognosis of LAR in (65 y above) investigate factors associated anastomotic leakage (AL). Besides, sought create a nomogram precise prediction AL after cancer.A total 343 65 years old who underwent or OAR at...
BACKGROUND:Inositol is an essential nutrient for cell growth, survival and embryonic development. Myo-inositol the predominant form in natural. To investigate correlation between inositol metabolism development, we assessed metabolic characteristics of myo-inositol, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂) 3,4,5-trisphosphate (PI(3,4,5)P₃) pregnant women North China (Yangquan Weihai) South (Nanchang Haikou) China. MATERIAL AND METHODS:All data were collected by face-to-face...
Laparoscopic radical gastrectomy has been increasingly applied in China. However, how to reduce surgery-related trauma, shorten operative time and achieve the long-term prognosis equal conventional open surgery is still hot research topics. Along with change learning curve optimization of endoscopic techniques, laparoscopic lymph node dissection can or even exceed extent that be achieved surgery. Therefore, it gradually replaced digestive tract reconstruction using an auxiliary incision. By...
Purpose This study aimed to evaluate the impact of type 2 diabetes mellitus (T2DM) on short-term outcomes and long-term survival patients with colorectal cancer (CRC) who underwent curative resection. Methods retrospectively included 136 (T2DM group) resectable CRC T2DM from Jan 2013 Dec 2017. Propensity score-matched control group consisting (non-T2DM were selected 1143 without T2DM. The prognosis compared between non-T2DM group. Results A total 272 (136 for each in this study. Patients had...
<p>Supplementary Information PDF file - 77K, Additional information on the HER2 Domain 4 sequence, methods and figure legends for supplemental figures</p>
Objective To evaluate the effect of preoperative oral rehydration on postoperative recovery in patients undergoing laparoscopic radical resection colorectal cancer. Methods Eighty both sexes, aged 18-64 yr, with body mass index 18-24 kg/m2, American Society Anesthesiologists physical status ⅠorⅡ, scheduled for elective cancer, were randomly divided into either routine fluid replacement group (group R) or O) 40 each group.Fasting solid food was performed at 8 h before surgery and water...