A5100387910- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Bone fractures and treatments
- Extracellular vesicles in disease
- Chronic Kidney Disease and Diabetes
- Diet, Metabolism, and Disease
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Cancer, Hypoxia, and Metabolism
- Trauma Management and Diagnosis
- Hepatitis B Virus Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- HIV, Drug Use, Sexual Risk
- Cellular transport and secretion
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Fibroblast Growth Factor Research
- Hepatitis C virus research
- Shoulder and Clavicle Injuries
- Neuroscience and Neural Engineering
- Genetic Associations and Epidemiology
- Therapeutic Uses of Natural Elements
Beijing Sport University
2025
Chengdu Sport University
2025
Collaborative Innovation Center of Chemistry for Energy Materials
2024
Xiamen University
2021-2024
Jiangsu Province Hospital
2024
Yichun University
2024
Nanjing Medical University
2024
University of Illinois Urbana-Champaign
2001-2023
Zhejiang Chinese Medical University
2022-2023
Affiliated Hospital of Southwest Medical University
2023
The Glasgow Outcome Scale (GOS) and its most recent revision, the GOS–Extended (GOS-E), provide gold standard for measuring traumatic brain injury (TBI) outcome. GOS-E exhibits validity when used with adults some adolescents, but younger children is not established. Because lacks developmental specificity necessary to evaluate children, toddlers, infants, we modified original version create Pediatric Revision (GOS-E Peds), a developmentally appropriate structured interview, classify...
Intercellular signaling is indispensable for single cells to form complex biological structures, such as biofilms, tissues and organs. The genetic tools available engineering intercellular signaling, however, are quite limited. Here we exploit the chemical diversity of small molecules de novo design a toolbox high-performance, multi-channel cell-cell communications computations. By biosynthetic pathway signal molecules, rational sensing promoters directed evolution transcription factors,...
Background and Aims: NASH, characterized by inflammation fibrosis, is emerging as a leading etiology of HCC. Lipidomics analyses in the liver have shown that levels polyunsaturated phosphatidylcholine (PC) are decreased patients with but roles membrane PC composition pathogenesis NASH not been investigated. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), phospholipid (PL) remodeling enzyme produces PLs, major determinant content liver. Approach Results: The expression LPCAT3 correlation...
Aberrant activation of β-catenin and Yes-associated protein (YAP) signaling pathways has been associated with hepatocellular carcinoma (HCC) progression. The LIM domain Ajuba regulates YAP is implicated in tumorigenesis. However, roles mechanism expression HCC cells remain unclear. E3 ligase Hakai shown to interact other family members whether interacts unknown. cell lines stably depleted or were established using lentiviruses expressing shRNAs against Hakai. effects on determined by a...
Abstract The liver plays a central role in regulating glucose and lipid metabolism. Aberrant insulin action the is major driver of selective resistance, which fails to suppress production but continues activate lipogenesis liver, resulting hyperglycemia hypertriglyceridemia. underlying mechanisms resistance are not fully understood. Here It shown that hepatic membrane phospholipid composition controlled by lysophosphatidylcholine acyltransferase 3 (LPCAT3) regulates signaling systemic...
The aim of the study was to assess association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing 5 different adiposity indices: visceral fat index (VFI), percentage body (PBF), mass (BMI), waist circumference (WC) waist-to-height ratio (WHtR).A total 29,516 participants aged 35 years or above were selected using a stratified multistage random sampling method across China during 2012-2015. defined as an estimated glomerular filtration...
The protective efficacy of COVID-19 vaccinations has declined over time such that booster doses are required.To evaluate the and adverse events two inactivated vaccines.This is a double-blind, randomized, placebo-controlled phase 3 trial aiming to efficacy, safety, immunogenicity SARS-CoV-2 vaccine (Vero cells) after inoculation with vaccine.Healthy volunteers were recruited in an earlier vaccine. participants Abu Dhabi maintained blind state received dose or placebo at least six months...
Genome-wide association studies (GWAS) have identified genetic variants in SEC16 homolog B (SEC16B) locus to be associated with obesity and body mass index (BMI) various populations. SEC16B encodes a scaffold protein located at endoplasmic reticulum (ER) exit sites that is implicated participate the trafficking of COPII vesicles mammalian cells. However, function vivo, especially lipid metabolism, has not been investigated. We generated Sec16b intestinal knockout (IKO) mice assessed impact...
Glycans, particularly sialic acids (SAs), play crucial roles in diverse biological processes. Despite their significance, analyzing specific glycans, such as acids, on individual small extracellular vesicles (sEVs) has remained challenging due to the limited glycan capacity and substantial heterogeneity of sEVs. To tackle this issue, we introduce a chemical modification method surface SAs sEVs named PALEV-nFCM, which involves periodate oxidation aniline-catalyzed oxime ligation (PAL),...
ABSTRACT The relationships between expansion volume and physical properties of three varieties popcorn kernels were investigated on a single kernel basis. Physical studied size, sphericity, density. Methods measuring densities popped volumes individual developed. Popcorn separated into seven sizes by screening with round‐hole sieves. Thirty from each (4.76 < D 5.16, 5.56 5.95, 6.35 6.75 mm) individually measured for density, volume. Density sphericity measures showed little variability....
Background: Myocardial injury after noncardiac surgery (MINS) has been associated with worse outcomes. The aim of our study was to investigate the relationship between higher red blood cell distribution width (RDW) and postoperative 30-day MINS among advanced-age patients. Methods: This a retrospective observational including patients (≥ 65 years old) who underwent January 2017 August 2019 at First Medical Center Chinese People's Liberation Army General Hospital. Patients were divided into...
Previous studies have revealed that membrane phospholipid composition controlled by lysophosphatidylcholine acyltransferase 3 (LPCAT3) is involved in the development of insulin resistance type 2 diabetes. In this study, we aimed to investigate therapeutic potential targeting Lpcat3 treatment diabetic mouse models. expression was suppressed whole body antisense oligonucleotides (ASO) injection or liver adeno-associated virus (AAV)-encoded Cre high-fat diet (HFD)-induced and genetic ob/ob...
Abstract Hypoxia has been highly proven a hallmark of tumor micro‐environment, promoting the malignant phenotypes, playing crucial role from initiation, progression, invasion, and intravasation to metastatic dissemination outgrowth. Increasing evidence also showed that hypoxia mediated abnormal lipid metabolism in cancer by regulating various oncogenic signal pathways. However, it is still unclear but attractive how specifically functioned changed condition micro‐environment. In present...
Thrombophilia is an important cause of recurrent spontaneous abortion (RSA). The treatment thrombophilia beneficial to the prevention RSA. Therefore, we explored clinical effect Chinese traditional herbs with effects invigorating blood, tonifying kidney and calming fetus in RSA complicated thrombophilia. We retrospectively analyzed outcomes 190 patients combined using different methods. medicine group was treated kidney-invigorating, blood-activating fetus-soothing western low molecular...