A5022358779- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Organic Light-Emitting Diodes Research
- RNA and protein synthesis mechanisms
- Organic Electronics and Photovoltaics
- DNA and Biological Computing
- Evolution and Genetic Dynamics
- CRISPR and Genetic Engineering
- Gene Regulatory Network Analysis
- Genomics and Phylogenetic Studies
- Modular Robots and Swarm Intelligence
- Bacterial Genetics and Biotechnology
- Advanced Materials and Mechanics
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Analysis
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Luminescence Properties of Advanced Materials
- Photochemistry and Electron Transfer Studies
- Magnetism in coordination complexes
- Single-cell and spatial transcriptomics
- Mercury impact and mitigation studies
- Micro and Nano Robotics
The Second Nanning People's Hospital
2024
The Fourth People's Hospital
2023-2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Center for Life Sciences
2018-2024
Shenyang University of Chemical Technology
2023-2024
Peking University
2018-2024
Southern Medical University
2024
Inspired by the water-collecting mechanism of Stenocara beetle's back structure, we prepared a superhydrophilic bumps-superhydrophobic/superoleophilic stainless steel mesh (SBS-SSM) filter via facile and environmentally friendly method. Specifically, hydrophilic silica microparticles are assembled on as-cleaned surface, followed further spin-coating with fluoropolymer/SiO2 nanoparticle solution. On special surface SBS-SSM, attributed to steep energy gradient, bumps (hydrophilic...
High quality carbon dots (C-dots) with down- and up-conversion fluorescence have been synthesized through low-temperature carbonization using sweet pepper as the source. The C-dots a quantum yield (QY) of 19.3% exhibit superior photophysical properties, for example, narrow symmetric emission spectra, large stock shifts, resistance to photobleaching, excitation-dependent behavior. excellent serve useful fluorescent probes hypochlorite (ClO−) detection by both fluorescence. Two consecutive...
The global demand for data storage is currently outpacing the world's capabilities. DNA, carrier of natural genetic information, offers a stable, resource- and energy-efficient sustainable solution. In this review, we summarize fundamental theory, research history, technical challenges DNA storage. From quantitative perspective, evaluate prospect organic polymers in general, as novel class medium.
We developed an in vitro DNA detection system using a pair of dCas9 proteins linked to split halves luciferase. Luminescence was induced upon colocalization the reporter ∼44 bp target sequence defined by sgRNAs. used detect Mycobacterium tuberculosis with high specificity and sensitivity. The reprogrammability further leveraged array design that accesses information across entire genome.
Tumor necrosis factor (TNF-α) is capable of inducing apoptosis and a promising candidate for genetic engineering drugs in cancer therapy; however, the serious side-effects TNF-α hinder their clinical application. In present study, method preparing fusion proteins cell-penetrating peptides (CPP) (CTNF-α)-anchored exosomes coupled with superparamagnetic iron oxide nanoparticles (CTNF-α-exosome-SPIONs) membrane targeting anticancer activity has been demonstrated. To acquire anchored its...
Intercellular signaling is indispensable for single cells to form complex biological structures, such as biofilms, tissues and organs. The genetic tools available engineering intercellular signaling, however, are quite limited. Here we exploit the chemical diversity of small molecules de novo design a toolbox high-performance, multi-channel cell-cell communications computations. By biosynthetic pathway signal molecules, rational sensing promoters directed evolution transcription factors,...
DNA storage has shown potential to transcend current silicon-based data technologies in density, longevity and energy consumption
In this work, we introduced a siderophore information database (SIDERTE), digitized containing 649 unique structures. Leveraging digitalized data set, gained systematic overview of siderophores by their clustering patterns in the chemical space. Building upon this, developed functional group-based method for predicting new iron-binding molecules with experimental validation. Expanding our approach to collection open natural products (COCONUT) database, predicted staggering 3199 candidates,...
Abstract Ionogels, recognized for their flexibility and ionic conductivity, show considerable promise across various applications including electronic skins, biomedical electronics, smart robotics. However, the majority of ionogels are plagued by suboptimal mechanical strength, a restricted range operating temperatures, poor recyclability. Here, an acetone‐stimulated supramolecular reinforcement strategy to develop robust environmentally tolerant is introduced. The bio‐based feature firm...
Abstract BAY55‐9837, a potential therapeutic peptide in the treatment of type 2 diabetes mellitus (T2DM), is capable inducing glucose (GLC)‐dependent insulin secretion. However, benefit BAY55‐9837 limited by its short half‐life, lack targeting ability, and poor blood GLC response. How to improve response an existing problem that needs be solved. In this study, method for preparing BAY55‐9837‐loaded exosomes coupled with superparamagnetic iron oxide nanoparticle (SPIONs) pancreas islet...
DNA has been pursued as a novel biomaterial for digital data storage. While large-scale storage and random access have achieved in oligonucleotide pools, repeated accessing requires constant replenishment, these implementations are confined professional facilities. Here, mobile system the genome of extremophile Halomonas bluephagenesis, which enables dual-mode storage, dynamic maintenance, rapid readout, robust recovery. The relies on two key components: A versatile genetic toolbox...
Non-ribosomal peptide synthetase (NRPS) is a diverse family of biosynthetic enzymes for the assembly bioactive peptides. Despite advances in microbial sequencing, lack consistent standard annotating NRPS domains and modules has made data-driven discoveries challenging. To address this, we introduced standardized architecture NRPS, by using known conserved motifs to partition typical domains. This motif-and-intermotif standardization allowed systematic evaluations sequence properties from...
Current research is mainly trending toward addressing the development of multifunctional nanocarriers that could precisely reach disease sites, release drugs in a controlled-manner, and act as an imaging agent for both diagnosis targeted therapy. In this study, pH-sensitive theranostic nanoplatform promising dual-functional nanovector tumor therapy computed tomography (CT) was developed. The 21-arm star-like triblock polymer β-cyclodextrin-{poly(ε-caprolactone)-poly(2-aminoethyl...
Abstract Context-dependency of mammalian transcriptional elements has hindered the quantitative investigation multigene expression stoichiometry and its biological functions. Here, we describe a host- local DNA context-independent transcription system to gradually fine-tune single multiple gene with predictable stoichiometries. The is composed library modular programmable promoters from bacteriophage cognate RNA polymerase (RNAP) fused capping enzyme. relative genes quantitatively determined...
The characterization of structural variants (SVs) is fundamental to genomic studies and advanced computational approaches are on demand exert the ability ubiquitous high-throughput sequencing data. Herein, we propose gcSV, a read-length agnostic alignment-based approach well-handle issues genome repeats, SV breakpoints read alignments/assemblies for comprehensive, cost-effective versatile calling. For long reads, its yield 20-38% higher than state-of-the-art tools in HG002 benchmark. hybrid...