A5085506207- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Polysaccharides Composition and Applications
- MicroRNA in disease regulation
- Pharmacological Effects and Toxicity Studies
- Cannabis and Cannabinoid Research
- Nanopore and Nanochannel Transport Studies
- Nanoplatforms for cancer theranostics
- Probiotics and Fermented Foods
- Nanoparticle-Based Drug Delivery
- Natural Antidiabetic Agents Studies
- Bioactive natural compounds
- Advanced Drug Delivery Systems
- Autophagy in Disease and Therapy
- Neuropeptides and Animal Physiology
- Rabbits: Nutrition, Reproduction, Health
Shaoguan University
2023-2024
Chengdu Medical College
2018-2024
Center for Innovation
2019
Chengdu University
2019
Jinan University
2014
Tumor necrosis factor (TNF-α) is capable of inducing apoptosis and a promising candidate for genetic engineering drugs in cancer therapy; however, the serious side-effects TNF-α hinder their clinical application. In present study, method preparing fusion proteins cell-penetrating peptides (CPP) (CTNF-α)-anchored exosomes coupled with superparamagnetic iron oxide nanoparticles (CTNF-α-exosome-SPIONs) membrane targeting anticancer activity has been demonstrated. To acquire anchored its...
Abstract BAY55‐9837, a potential therapeutic peptide in the treatment of type 2 diabetes mellitus (T2DM), is capable inducing glucose (GLC)‐dependent insulin secretion. However, benefit BAY55‐9837 limited by its short half‐life, lack targeting ability, and poor blood GLC response. How to improve response an existing problem that needs be solved. In this study, method for preparing BAY55‐9837‐loaded exosomes coupled with superparamagnetic iron oxide nanoparticle (SPIONs) pancreas islet...
Purpose: As a potential protein therapeutic for type 2 diabetes mellitus (T2DM), BAY 55-9837 is limited by poor stability and very short half-life in vivo. The purpose of this study was to construct novel nanostructured biomaterial conjugating chitosan-decorated selenium nanoparticles (CS-SeNPs) prolong the vivo reducing its renal clearance rate. Materials methods: 55-9837-loaded CS-SeNPs (BAY-CS-SeNPs) were prepared, their surface morphology, particle size, zeta potential, structure...
The traditional Chinese medicine - the flower of Edgeworthia gardneri is reported as an effective therapeutic for type 2 diabetes mellitus (T2DM). Nevertheless, most constituents flowers E. have not yet been studied. This study was conducted to investigate effect quercetin extracted from on islet protection and amelioration in T2DM explore its mechanism.Quercetin verified by high-performance liquid chromatography. Quercetin or crude extract's insulin secretion investigated. ERK1/2...
Quercetin has an ideal therapeutic effect on islet function improvement in type 2 diabetes mellitus (T2DM). However, the benefit of quercetin is hindered by its poor bioavailability and limited concentration pancreatic islets. In this study, superparamagnetic iron oxide nanoparticle (SPION)-modified exosomes were prepared to load quercetin, hoping endow with enhanced water solubility active targeting capacity help magnetic force (MF).Transferrin-modified SPIONs (Tf-SPIONs) synthesized...