A5100770707- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- ECG Monitoring and Analysis
- Angiogenesis and VEGF in Cancer
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiac Fibrosis and Remodeling
- Heart Rate Variability and Autonomic Control
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Autophagy in Disease and Therapy
- Cardiac electrophysiology and arrhythmias
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- EEG and Brain-Computer Interfaces
- Antiplatelet Therapy and Cardiovascular Diseases
Chinese PLA General Hospital
2016-2025
Chinese People's Liberation Army
2013-2024
Nankai University
2024
Shandong Institute of Automation
2022
Chinese Academy of Sciences
2022
University of Liverpool
2022
Liverpool Heart and Chest Hospital
2022
Chinese General Hospital College of Nursing and Liberal Arts
2014-2021
PLA Academy of Military Science
2021
Clinical Trial Investigators
2021
Impaired cardiac microvascular function contributes to diabetic cardiovascular complications although effective therapy remains elusive. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor recently approved for treatment of type diabetes, promotes glycosuria excretion and offers cardioprotective actions beyond its glucose-lowering effects. This study was designed evaluate the effect empagliflozin on injury in diabetes underlying mechanism involved with focus mitochondria. Our...
Disturbed mitochondrial homeostasis contributes to the pathogenesis of cardiac ischemia reperfusion (IR) injury, although underlying mechanism remains elusive. Here, we demonstrated that casein kinase 2α (CK2α) was upregulated following acute IR injury. Increased CK2α shown be instrumental damage, cardiomyocyte death, infarction area expansion and dysfunction, whereas cardiac-specific knockout (CK2αCKO) mice were protected against injury damage. Functional assay indicated enhanced...
Abstract The cardiac microvascular system, which is primarily composed of monolayer endothelial cells, the site blood supply and nutrient exchange to cardiomyocytes. However, ischemia/reperfusion injury ( IRI ) following percutaneous coronary intervention a woefully neglected topic, few strategies are available reverse such pathologies. Here, we studied effects melatonin on microcirculation elucidated underlying mechanism. Melatonin markedly reduced infarcted area, improved function,...
Receptor-interacting protein 3 (Ripk3)-mediated necroptosis contributes to cardiac ischaemia-reperfusion (IR) injury through poorly defined mechanisms. Our results demonstrated that Ripk3 was strongly upregulated in murine hearts subjected IR and cardiomyocytes treated with LPS H2O2. The higher level of positively correlated the infarction area expansion, dysfunction augmented necroptosis. Function study further illustrated evoked endoplasmic reticulum (ER) stress, which accompanied an...
Abstract Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to sustain homeostasis under stress conditions. However, no study has confirmed whether OPA1‐related fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death in the setting of cardiac ischemia‐reperfusion (I/R) injury. Our results indicated that OPA1, fusion, were significantly repressed I/R injury, accompanied infarction area expansion, heart dysfunction, myocardial...
Ripk3-required necroptosis and mitochondria-mediated apoptosis are the predominant types of cell death that largely account for development cardiac ischemia reperfusion injury (IRI). Here, we explored effect Ripk3 on mitochondrial apoptosis. Compared with wild-type mice, infarcted area in Ripk3-deficient (Ripk3-/-) mice had a relatively low abundance apoptotic cells. Moreover, loss protected mitochondria against IRI inhibited caspase9 pathways. These protective effects deficiency were relied...
The cardiac microvascular system ischemia/reperfusion injury following percutaneous coronary intervention is a clinical thorny problem. This study explores the mechanisms by which induces microcirculation collapse. In wild-type mice, mitochondrial fission factor (Mff) expression increased in response to acute injury. Compared with homozygous Mff-deficient (Mffgt) mice exhibited smaller infarcted area, restored function, improved blood flow, and reduced perfusion defects. Histopathology...
Abstract Platelet activation is a major (patho‐) physiological mechanism that underlies ischemia/reperfusion (I/R) injury. In this study, we explored the molecular signals for platelet hyperactivity and investigated beneficial effects of melatonin on reactivity in response to I/R After reperfusion, peroxisome proliferator‐activated receptor γ ( PPAR γ) was progressively downregulated patients with acute myocardial infarction undergoing coronary artery bypass grafting CABG ) surgery mice...
The molecular features of necroptosis in cardiac ischemia-reperfusion (IR) injury have been extensively explored. However, there no studies investigating the physiological regulatory mechanisms melatonin acting on IR injury. This study was designed to determine role microvascular injury, and investigate contribution repressing preventing IR-mediated endothelial system collapse. Our results demonstrated that Ripk3 primarily activated by consequently aggravated necroptosis, microvessel barrier...
BackgroundMobile Health technology for the management of patients with atrial fibrillation is unknown.MethodsThe simple mobile AF (mAF) App was designed to incorporate clinical decision-support tools (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes Mellitus, Prior Stroke or TIA, Vascular disease, 65–74 Sex category], HAS-BLED [Hypertension, Abnormal renal/liver function, Stroke, Bleeding history predisposition, Labile INR, Elderly, Drugs/alcohol concomitantly],...
The cardiac microvascular reperfusion injury is characterized by the endothelial cells (CMECs) oxidative damage which responsible for progression of dysfunction. However, few strategies are available to reverse such pathologies. This study aimed explore mechanism stress induced CMECs death and beneficial actions melatonin on survival, with a special focused IP3R-[Ca2+]c/VDAC-[Ca2+]m axis MAPK/ERK survival signaling. We found that H2O2 significantly activated cAMP response element binding...
Abstract Mesenchymal stem cells (MSC) are regarded as an attractive source of therapeutic for myocardial infarction. However, their limited self-renewal capacity, low migration capacity and poor viability after transplantation hamper the clinical use MSC; thus, a strategy to enhance biological functions MSC is required. Exendin-4 (Ex-4), glucagon-like peptide-1 receptor agonist, exerts cell-protective effects on many types cells. little information available regarding influence Ex-4 MSC. In...
Abstract Objective To investigate the correlation between clinical characteristics and cardiac injury of COVID-2019 pneumonia. Methods In this retrospective, single-center study, 41 consecutive corona virus disease 2019 (COVID-2019) patients (including 2 deaths) in Beijing Youan Hospital, China Jan 21 to Feb 03, 2020, were involved study. The high risk factors different analyzed. Computed tomographic (CT) imaging epicardial adipose tissue (EAT) has been used demonstrate inflammation...