A5100641510- Liver Disease Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Atrial Fibrillation Management and Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Nitric Oxide and Endothelin Effects
- Polyomavirus and related diseases
- Peroxisome Proliferator-Activated Receptors
- Acute Ischemic Stroke Management
- Sinusitis and nasal conditions
- Natural Compounds in Disease Treatment
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Pregnancy and preeclampsia studies
- Cardiac Fibrosis and Remodeling
- Advanced biosensing and bioanalysis techniques
- Cardiovascular Function and Risk Factors
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Blood Pressure and Hypertension Studies
- Acute Lymphoblastic Leukemia research
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare and Venom Research
- Pluripotent Stem Cells Research
- Allergic Rhinitis and Sensitization
Central South University
2009-2025
Xiangya Hospital Central South University
2008-2025
Xian Central Hospital
2025
Zhongnan Hospital of Wuhan University
2023-2024
Wuhan University
2023-2024
Wuhan Union Hospital
2024
Shanghai Traditional Chinese Medicine Hospital
2023
Huazhong University of Science and Technology
2022-2023
Chengdu University of Traditional Chinese Medicine
2023
University of Liverpool
2022
Background Current management of patients with atrial fibrillation (AF) is limited by low detection AF, non-adherence to guidelines and lack consideration patient's preferences, thus highlighting the need for a holistic integrated approach AF management. This study aims determine whether mHealth technology-supported strategy will reduce AF-related adverse events. Methods/design The mAFA II trial prospective, cluster randomised controlled trial. 40 sites be mAFA-integrated care intervention...
<h3>Importance</h3> The Mobile Health Technology for Improved Screening and Optimized Integrated Care in Atrial Fibrillation (mAFA-II) trial is a prospective cluster randomized that found significant reduction the composite clinical outcome of stroke or thromboembolism, all-cause death, rehospitalization among patients with atrial fibrillation (AF) who used mobile health (mHealth) technology implemented Better (ABC) pathway (ie, A, anticoagulation/avoid stroke; B, better symptom control; C,...
BACKGROUND: Helicoverpa armigera (Hübner) causes severe losses in many crops including cotton. Cytochrome P450s play crucial roles the metabolism of important compounds various organisms. The authors attempt to identify new cytochrome P450 genes and investigate their expression profile xenobiotic response order understand nature this pest. RESULTS: A novel cDNA (CYP9A17), encoding a protein 531 amino acid residues, was isolated from H. armigera. CYP9A17 is typical microsomal P450, showing...
Doxorubicin (DOX) is commonly used for chemotherapy; however, its clinical value extremely dampened because of the fatal cardiotoxicity. Leucine zipper protein 1 (LUZP1) plays critical roles in cardiovascular development, and this study designed determining function mechanism DOX-induced cardiotoxicity.Cardiac-specific Luzp1 knockout (cKO) transgenic (cTG) mice received a single or repeated DOX injections to establish acute chronic Biomarkers inflammation, oxidative damage cell apoptosis...
<title>Abstract</title> Lung cancer is one of the most lethal type malignancy in world. Polyphenolic compounds such as curcumin, which are found certain plant foods, considered chemotherapeutic agents that induce their effect through anti-proliferative, anti-estrogenic, and pro-oxidant properties associated with cancer. In this study, we investigated effects curcumin on chemosensitivity A549 cells to doxorubicin (DOX). A549/DOX treated DOX MTT assay was applied investigate cell viability....
Background: Diabetic wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) are challenging to heal due biofilm formation, which impairs conventional antibiotics limited penetration and severe side effects. Near-infrared (NIR)-driven nanomotors autonomous motion photothermal effects show promise for antibacterial therapy but often lack targeted specificity. Lysostaphin (Ly), an enzyme targeting bacterial cell walls, offers excellent potential against drug-resistant MRSA....
Rheumatoid arthritis (RA) and cervical cancer (CC) are major global health challenges, yet the molecular connections between these two conditions remain poorly understood. To bridge this gap, our study employs bioinformatics approaches to explore shared genetic pathways potential biomarkers. We started by identifying differentially expressed genes in RA CC then applied WGCNA detect functionally related gene clusters using expression data from GEO database. Additionally, we constructed...
Background Previous experimental studies have reported an association between microcystin-LR (MC-LR) and glucose homeostasis, but whether exposure to MC-LR is a risk factor for the pathogenesis of gestational diabetes mellitus (GDM) requires further epidemiological study. This study aims explore effects on GDM. Methods A prospective nested case-control was performed in Hunan Provincial Maternal Child Health Hospital (HPMCHH) South China. total 119 patients with GDM 238 controls were enrolled...
Soluble guanylyl cyclase (sGC) is the principal receptor for nitric oxide (NO) and crucial control of various physiological functions. The β1 subunit sGC obligatory biological stability activity heterodimer. MicroRNAs (miRNAs) are important regulators gene expression exert great influences on diverse activities. aim present study was to determine whether or not sGCβ1 specifically regulated by miRNAs. We report that miR-34c-5p directly targets under hypoxia. Bioinformatics analysis...
Abstract Background The Mobile Health Technology for Improved Screening and Optimized Integrated Care in AF (mAFA-II) randomised trial demonstrated the efficacy of a mobile health (mHealth) technology-implemented ‘Atrial fibrillation Better Care’ (ABC) pathway-approach (mAFA intervention) reducing risk adverse events patients with atrial (AF). Whether these benefits also apply to older is unclear. In this ancillary analysis, we evaluated effect mAFA intervention among patients. Methods...
The aim of this study was to identify the target nonalcoholic fatty liver disease (NAFLD) cell-specific aptamer NAFLD01 and investigate its effect on lipid metabolism in vitro. A distinct membrane protein NAFLD cells pulled down by analyzed mass spectrometry determine candidates, affinity target-protein-silent detected validate it. Knockdown CD36 abolished binding NAFLD01, associated with membrane-bound CD36. for proportional expression level. Moreover, compared random sequences, showed...
Bacterial infections are very common among patients with hematological diseases. Scant data available regarding differences in the epidemiology and biological features of bacterial neutropenic non-neutropenic patients.The aim this survey was to compare pathogens same ward during an 8-year period.A total 1139 strains were isolated from 1071 The percentage Gram-negative bacteria significantly higher than (70.4% vs. 55.0%, respectively, P < .01). In patients, most commonly-isolated bacterium...
Cardiac hypertrophy is an important contributor of heart failure, and the mechanisms remain unclear. Leucine zipper protein 1 (LUZP1) essential for development function cardiovascular system; however, its role in cardiac elusive.
Background. Antihypertensive therapy is crucial for preventing stroke in hypertensive patients. However, the efficacy of antihypertensive varies across individuals, partially due to therapy-related genetic variations among individuals. We investigated association drug-related gene polymorphism with patients hypertension. Methods. Demographic information, medication, and outcome data were obtained from a patient management system, PCR fluorescence probe technique was used detect 7 polymorphic...
Inflammation and oxidative damage play critical roles in the pathogenesis of sepsis-induced cardiac dysfunction. Multiple EGF-like domains 9 (MEGF9) is essential for cell homeostasis; however, its role mechanism injury impairment remain unclear.