A5048601229- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Air Quality and Health Impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Climate Change and Health Impacts
- Traumatic Brain Injury Research
- Atrial Fibrillation Management and Outcomes
- Nutritional Studies and Diet
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
- Effects and risks of endocrine disrupting chemicals
- Simulation-Based Education in Healthcare
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- Cardiac Arrhythmias and Treatments
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Global Health Care Issues
- Neurological Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Gut microbiota and health
- COVID-19 diagnosis using AI
Zhongnan Hospital of Wuhan University
2013-2025
Wuhan University
2013-2025
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Qinghai Provincial Peoples Hospital
2018-2023
Central Hospital of Wuhan
2023
Weatherford College
2023
Lawrence Berkeley National Laboratory
2021-2022
University of Liverpool
2022
Liverpool Heart and Chest Hospital
2022
Abstract Background Lower-grade gliomas (LGG) are heterogeneous diseases by clinical, histological, and molecular criteria. We aimed to personalize the diagnosis therapy of LGG patients developing validating robust cellular morphometric subtypes (CMS) uncover signatures underlying these subtypes. Methods Cellular biomarkers (CMBs) were identified with artificial intelligence technique from TCGA-LGG cohort. Consensus clustering was used define CMS. Survival analysis performed assess clinical...
Background Current management of patients with atrial fibrillation (AF) is limited by low detection AF, non-adherence to guidelines and lack consideration patient's preferences, thus highlighting the need for a holistic integrated approach AF management. This study aims determine whether mHealth technology-supported strategy will reduce AF-related adverse events. Methods/design The mAFA II trial prospective, cluster randomised controlled trial. 40 sites be mAFA-integrated care intervention...
Abstract Background N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA. It has been reported that there a stimulus-dependent regulation m6A in mammalian central nervous system response to sensory experience, learning, and injury. The mRNA methylation pattern rat cortex after traumatic brain injury (TBI) not investigated. Results In this study, we conducted genome-wide profiling via methylated RNA immunoprecipitation sequencing (MeRIP-Seq)....
<h3>Importance</h3> The Mobile Health Technology for Improved Screening and Optimized Integrated Care in Atrial Fibrillation (mAFA-II) trial is a prospective cluster randomized that found significant reduction the composite clinical outcome of stroke or thromboembolism, all-cause death, rehospitalization among patients with atrial fibrillation (AF) who used mobile health (mHealth) technology implemented Better (ABC) pathway (ie, A, anticoagulation/avoid stroke; B, better symptom control; C,...
Various risk factors influence obesity differently, and environmental endocrine disruption may increase the occurrence of obesity. However, most previous studies have considered only a unitary exposure or set similar exposures instead mixed exposures, which entail complicated interactions. We utilized three statistical models to evaluate correlations between chemicals analyze association 9 different chemical in children adolescents.We fitted generalized linear regression, weighted quantile...
Abstract Growing evidence suggests that the gut microbiome (GM) plays a critical role in health and disease. However, contribution of GM to psychiatric disorders, especially anxiety, remains unclear. We used Collaborative Cross (CC) mouse population-based model identify anxiety associated host genetic factors. Anxiety-like behavior 445 mice across 30 CC strains was measured using light/dark box assay documented by video. A custom tracking system developed quantify seven anxiety-related...
Traumatic brain injury (TBI) is a widespread central nervous system (CNS) condition and leading cause of death, disability, long-term disability including seizures emotional behavioral issues.To date, applicable diagnostic biomarkers have not been elucidated.MicroRNAs (miRNAs) are enriched stable in exosomes plasma.Therefore, we speculated that miRNAs plasma might serve as novel for TBI diagnosis also involved the pathogenesis TBI.In this study, first isolated from peripheral blood rats with...
Neurological diseases are a significant contributor to premature mortality and temporary or long-term disability among survivors. Asia serves as an essential region for assessing the shifting burden of these disorders. This study aims calculate evaluate changes in neurological across Asia. The Global Burden Disease database provided data on deaths, disability-adjusted life-years (DALYs), incidence, prevalence from 1990 2021 Asian subregions countries. Twelve common were analyzed. Estimated...
Carbon monoxide (CO) poisoning represents a significant contributor to injury burden across Asia. This study seeks assess the of CO in Asia from 1990 2021 utilizing data Global Burden Disease Study (GBD) 2021. Data on 49 Asian countries were extracted GBD The variations analyzed according year, gender, location, age, and Socio-Demographic Index (SDI). Analyses included Joinpoint analysis evaluate temporal trends, age-period-cohort model disease slope index inequality concentration for...
Background: Gut microbiota is associated with the progression of brain tumors. However, alterations in gut observed during glioma growth and temozolomide (TMZ) therapy remain poorly understood. Methods: C57BL/6 male mice were implanted GL261 cells. TMZ/sodium carboxymethyl cellulose (SCC) was administered through gavage for five consecutive days (from 8 to 12 after implantation). Fecal samples collected before (T0) on 7 (T1), 14 (T2), 28 (T3) implantation. The analyzed using 16S ribosomal...
Notch signaling pathway is involved in many physiological and pathological processes. The γ-secretase inhibitor DAPT inhibits promotes nerve regeneration after cerebral ischemia. However, neuroprotective effects of against acute craniocerebral injury remain unclear. In this study, we established rat model injury, found that with the increase damage grade, expression downstream protein Hes1 Hes5 gradually increased. After administration DAPT, Notch, was inhibited, apoptosis oxidative stress...
Objectives The incidence of bystander cardiopulmonary resuscitation (CPR) is low in China. CPR training could improve public attitudes and willingness, but at present, the after online are unclear. This study investigated individual towards CPR, willingness to perform it emergencies along with main obstacles overall effects training. Design Questionnaires were distributed investigate performing CPR. Setting accessible course ‘First Aid’. Participants 1888 students who attended Aid’ from...
Cerebral Contusion (CC) is one of the most serious injury types in patients with traumatic brain (TBI). In this study, baseline data, imaging features and laboratory examinations CC were summarized analyzed to develop validate a prediction model nomogram evaluate clinical outcomes patients.A total 426 cerebral contusion admitted People's Hospital Qinghai Province Affiliated Qingdao University from January 2018 2021 included We randomly divided cohort into training (n = 284) validation 142)...
Abstract Objective Survival from out-of-hospital cardiac arrest (OHCA) often depends on the effective and immediate use of automated external defibrillators (AEDs). Given that there have been few studies about AED in China, purpose this study is to investigate knowledge attitudes regarding among Chinese public, then provide an suggestion for education strategies legislation. Method The online survey was conducted participants First Aid eLearning courses June 2020. Result A total 2565...
Abstract Background The Mobile Health Technology for Improved Screening and Optimized Integrated Care in AF (mAFA-II) randomised trial demonstrated the efficacy of a mobile health (mHealth) technology-implemented ‘Atrial fibrillation Better Care’ (ABC) pathway-approach (mAFA intervention) reducing risk adverse events patients with atrial (AF). Whether these benefits also apply to older is unclear. In this ancillary analysis, we evaluated effect mAFA intervention among patients. Methods...
Abstract Background High-quality chest compression is essential for successful cardiac arrest resuscitation. cardiopulmonary resuscitation (CPR) can effectively improve the survival rate of patients with arrest. However, bystanders untrained in may provide inadequate compressions. Previous studies have shown that use feedback devices training alone or simulated This study aims to determine whether using an audiovisual (AVF) device during CPR a (CA) scenario would be more effective improving...
Abstract: Inflammation plays critical roles in the acute progression of pathology ischemic injury. Previous studies have shown that triptolide interferes with a number pro-inflammatory mechanisms. In this study, we investigated whether has protective effects during cerebral ischemia/reperfusion (I/R) Male Sprague Dawley rats received or vehicle at onset reperfusion following middle artery occlusion. Twenty-four hours after reperfusion, evaluated neurological injuries, expression markers, and...
This study's purpose was to assess the attitudes and willingness of middle school students perform cardiopulmonary resuscitation (CPR) use automated external defibrillator (AED) in emergencies, evaluate overall effects first aid training.Middle demonstrated a high learn CPR (95.87%) AED (77.90%). However, rate (9.87%) (3.51%) training relatively low. These trainings could improve their confidence while facing emergencies. Their main concerns were "Lack knowledge", rescue skills" "Fear...