A5044239966- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Glaucoma and retinal disorders
- Oral microbiology and periodontitis research
- Colorectal Cancer Treatments and Studies
- Mesenchymal stem cell research
- Wnt/β-catenin signaling in development and cancer
- Palliative Care and End-of-Life Issues
- Ophthalmology and Eye Disorders
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- Ethics in medical practice
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Hippo pathway signaling and YAP/TAZ
- Patient-Provider Communication in Healthcare
- Neonatal and fetal brain pathology
- Corneal Surgery and Treatments
- Advanced biosensing and bioanalysis techniques
- Corneal surgery and disorders
- Cancer-related gene regulation
- Bladder and Urothelial Cancer Treatments
- Oral Health Pathology and Treatment
Southwest University
2025
Chengdu Third People's Hospital
2025
Tongji Hospital
2022-2024
Huazhong University of Science and Technology
2010-2024
Union Hospital
2020-2024
Northwest Women's and Children's Hospital
2021-2024
Sichuan Cancer Hospital
2024
Fudan University
2024
Fujian Provincial Cancer Hospital
2009-2024
Fujian Medical University
2018-2024
Endothelial tip cell outgrowth of blood-vessel sprouts marks the initiation angiogenesis which is critical in physiological and pathophysiological procedures. However, how mechanical characteristics extracellular matrix (ECM) modulates formation has been largely neglected. In this study, we found enhanced CD31 expression stiffening outer layer hepatocellular carcinoma than surrounding soft tissues. Stiffened promoted sprouting from endothelial (EC) spheroids upregulated expressions...
Background Current management of patients with atrial fibrillation (AF) is limited by low detection AF, non-adherence to guidelines and lack consideration patient's preferences, thus highlighting the need for a holistic integrated approach AF management. This study aims determine whether mHealth technology-supported strategy will reduce AF-related adverse events. Methods/design The mAFA II trial prospective, cluster randomised controlled trial. 40 sites be mAFA-integrated care intervention...
Abstract Cardiovascular disease is still the leading cause of mortality worldwide. Vascular endothelial dysfunction viewed as initial step most cardiovascular diseases. Many studies have indicated that periodontal pathogens, especially Porphyromonas gingivalis , are closely correlated with vascular homeostasis, but function P. and underlying mechanisms elusive. To illuminate effects elucidate on structural integrity, we developed infection models in vivo vitro. Endothelial cell...
Abstract Expanded newborn screening facilitates early identification and intervention of patients with inborn errors metabolism (IEMs), There is a lack disease spectrum data for many areas in China. To determine the genetic characteristics IEMs Xi'an city Shaanxi province northwest China, 146152 newborns were by MSMS from January 2014 to December 2019 61 referred analysis next generation sequencing (NGS) validated Sanger sequencing. Seventy-five two mothers diagnosed IEMs, an overall...
Abstract Angiogenesis is crucial for successful bone defect repair. Co‐transplanting Bone Marrow Stromal Cells (BMSCs) and Endothelial (ECs) has shown promise vascular augmentation, but it face challenges in hostile tissue microenvironments, including poor cell survival limited efficacy. In this study, the mitochondria of human BMSCs are isolated transplanted to from same batch passage number (BMSCs mito ). The significantly boosted ability ‐ECs promote angiogenesis, as assessed by vitro...
This study conducts various economic approaches implemented worldwide to augment teachers’ recruitment and retention. It commences by situating the criticality of teacher retention within broader ambit educational expansion reform worldwide. Each nation prioritizes recruiting retaining high-caliber educators, acknowledging critical role that remuneration additional professional opportunities play in attracting sustaining individuals teaching profession. systematic literature review analyzes...
Large-scale recommendation systems often adopt cascading architecture consisting of retrieval, pre-ranking, ranking, and re-ranking stages. With strict latency requirements, pre-ranking utilizes lightweight models to perform a preliminary selection from massive retrieved candidates. However, recent works focus solely on improving consistency with relying exclusively downstream Since input is derived the output, they will exacerbate sample bias (SSB) issue Matthew effect, leading sub-optimal...
Abstract Background Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) is a heterogeneous GC subtype characterized by the overexpression of HER2. To date, few specific targeted therapies have demonstrated durable efficacy in HER2-positive patients, with resistance to trastuzumab typically emerging within 1 year. However, mechanisms remain incompletely understood, presenting significant challenge clinical practice. Methods In this study, we integrated genetic...
Flood disasters have a huge effect on human life, the economy, and ecosystem. Quickly extracting spatial extent of flooding is necessary for disaster analysis rescue planning. Thus, extensive studies utilized optical or radar data extraction water distribution monitoring flood events. As quality detected inundation coverage by images degraded cloud cover, current products derived from sensors cannot meet needs rapid flood-range monitoring. The presented study proposes an adaptive...
Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli-responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design sensitive PEGylated photosensitizer-peptide nanofiber (termed PHHPEG
Considerable evidence indicates that the beta(2)-adrenoceptor agonist clenbuterol decreases apoptosis in a rodent model of ischaemic cardiomyopathy. In this study, we investigated effects on infarct size caused by myocardial ischaemia/reperfusion (I/R) anaesthetized rats.Rats were randomly assigned to following groups: (i) sham (ii) I/R (iii) + (iv) ICI 118551 (v) metoprolol (vi) (vii) pertussis toxin I/R. Under anaesthesia, left anterior descending coronary artery was occluded for 30 min...
To develop a core competency training curriculum system for emergency trauma nurses in China.A modified Delphi study design.The selection criteria participants identified practitioner roles were to be currently engaged care over 5 years, serve as the manager of or surgery department, and have bachelor's degree higher. A total 15 experts from three grade tertiary hospitals invited participate this by email face January 2022. The expert group comprised four specialist doctors 11 nurses. There...
<h3>Introduction/Background</h3> Iparomlimab and tuvonralimab (QL1706), a bifunctional PD-1/CTLA-4 dual blocker, showed preliminary efficacy in patients with cervical cancer phase 1 trial. <h3>Methodology</h3> This multi-center, open-label, single-arm, 2 trial (NCT05557565) recruited immune checkpoint inhibitors naïve recurrent or metastatic (r/m CC) who failed first-line platinum-based chemotherapy without bevacizumab, regardless of PD-L1 status. Intravenous injection iparomlimab 5.0 mg/kg...
5526 Background: Platinum-based chemotherapy with or without bevacizumab is the first-line treatment for patients recurrent metastatic cervical cancer, and options are limited cancer after treatment. Enlonstobart (SG001) a fully humanized high-affinity anti-PD-1 immunoglobulin G4 monoclonal antibody. Previous phase 1b study demonstrated that SG001 had promising efficacy in PD-L1 positive recurrent/metastatic cancer. Here we present safety results of II (ClinicalTrials. gov identifier:...
Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) poses a considerable challenge to patients and their families due its severe complications. Previous researches have highlighted the critical role of immune disorders in pathogenesis. However, fragmented studies based on isolated cases hinder comprehensive understanding this deadly illness. This study aimed explore overall landscape peripheral blood mononuclear cells (PBMCs) IVIG-resistant KD using single-cell RNA sequencing...