A5090088616- interferon and immune responses
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Advancements in PLL and VCO Technologies
- Low-power high-performance VLSI design
- Electronic Packaging and Soldering Technologies
- Electrostatic Discharge in Electronics
- Integrated Circuits and Semiconductor Failure Analysis
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Adenosine and Purinergic Signaling
- GDF15 and Related Biomarkers
- Parallel Computing and Optimization Techniques
- NF-κB Signaling Pathways
- Amoebic Infections and Treatments
- Mesenchymal stem cell research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Periodontal Regeneration and Treatments
- Cytokine Signaling Pathways and Interactions
- Cancer, Stress, Anesthesia, and Immune Response
- Hematopoietic Stem Cell Transplantation
- PI3K/AKT/mTOR signaling in cancer
- Bone Metabolism and Diseases
- Planarian Biology and Electrostimulation
- VLSI and Analog Circuit Testing
National Clinical Research Center for Digestive Diseases
2023-2025
Peking University
2007-2025
Center for Life Sciences
2023
Shenyang Pharmaceutical University
2023
Institute of Microelectronics
2010
Abstract PTEN is frequently mutated in human cancers and mutants promote tumor progression metastasis. mutations have been implicated immune regulation, however, the underlying mechanism largely unknown. Here, we report that PTENα, isoform of PTEN, remains active cancer bearing stop-gained mutations. Through counteraction CD8 + T cell-mediated cytotoxicity, PTENα leads to cell dysfunction accelerates immune-resistant progression. Clinical analysis further uncovers PTENα-active suppress host...
RIG-I/DDX58 plays a key role in host innate immunity. However, its therapeutic potential for inflammation-related cancers remains to be explored. Here we identify frameshift germline mutations of RIG-I occurring patients with colon cancer. Accordingly, Rig-ifs/fs mice bearing mutant Rig-i exhibit increased susceptibility colitis-related cancer as well enhanced inflammatory response chemical, virus or bacteria. In addition interruption mRNA translation, the mutation changes secondary...
Abstract Angiogenesis is crucial for successful bone defect repair. Co‐transplanting Bone Marrow Stromal Cells (BMSCs) and Endothelial (ECs) has shown promise vascular augmentation, but it face challenges in hostile tissue microenvironments, including poor cell survival limited efficacy. In this study, the mitochondria of human BMSCs are isolated transplanted to from same batch passage number (BMSCs mito ). The significantly boosted ability ‐ECs promote angiogenesis, as assessed by vitro...
Biophysical cues play a crucial role in T cell biology, yet their implications adoptive therapy (ACT) remain largely unknown. Here, we investigate the effect of electrical stimuli on CD8+ cells using charged substrate composed electroactive nanocomposites with tunable surface charge intensities. Electrical enhance persistence and tumor-suppressive efficacy transferred cells, effects dependent charge. Single-cell RNA-sequencing analysis unveils decrease virtual memory (Tvm) an increase...
The peripheral T cell pool is maintained at dynamic homeostasis through fine-tuning of thymic output and self-renewal naïve cells. Lymphopenia or reduced lymphocyte number implicated in autoimmune diseases, yet little known about the homeostatic mechanisms. Here, it reported that replication protein A1 (RPA1) plays a critical role homeostasis. Utilizing cell-specific Rpa1-deficient (Rpa1
Tissue-infiltrating neutrophils (TINs) secrete various signaling molecules to establish paracrine communication within the inflammatory milieu. It is imperative identify molecular mediators that control this secretory phenotype of TINs. The present study uncovers a neutrophil subset exhibits increased pro-inflammatory cytokine production and enhanced migratory capacity which highly related with periodontal pathogenesis. Further analysis identifies OTU domain-containing protein 1 (OTUD1)...
Cancer evades host immune surveillance by virtue of poor immunogenicity. Here, we report an suppressor, designated as PTIR1, that acts a promotor tumor resistance. PTIR1 is selectively induced in human cancers via alternative splicing DDX58 (RIG-I), and its induction closely related to outcome patients with cancer. Through blocking the recruitment leukocytes, facilitates cancer escape tumor-intrinsic resistance immunotherapeutic treatments. Unlike RIG-I, capable binding C terminus UCHL5...
Severe aplastic anemia (SAA) is a kind of bone marrow failure caused by complex pathogenesis, mainly characterized severe pancytopenia which causes anemia, hemorrhage, and infection. Natural killer (NK) cells, derived from hematopoietic stem cells (HSCs) or common lymphoid progenitors (CLP), play an important role in the innate immunity adaptive immune responses. Of receptors on NK NKp46/NCR1 considered to be activating receptor for cells. However, quantity function remains unknown.The...
Bacterial invasion in infected skin wounds triggers inflammation and impedes healing. Current therapeutic strategies incorporating drug interventions within wound dressings often result resistance delayed Here, we developed a comprehensive modality integrating piezoelectric fibrous dressing with controlled ultrasound stimulation for efficient healing an model. The electrospun composed of barium titanate (BaTiO
Abstract Regulation of the immune response is key to promoting bone regeneration by electroactive biomaterials. However, how electrical signals at micro‐ and nanoscale regulate subsequent angiogenesis during remains be elucidated. Here, distinctly different surface potential distributions on charged poly(vinylidene fluoridetrifluoroethylene) (P(VDF‐TrFE)) matrix surfaces are established altering dimensions ferroelectric nanofillers from 0D BaTiO 3 nanoparticles (homogeneous distribution,...
A systemic and comprehensive ESD-induced parasitic model is presented in this paper, which used to analyse the influences of electrostatic discharge (ESD) protection circuits on performance radio frequency applications. novel low-parasitic ESD structure made a 0.35μm 1P3M silicide CMOS process. The measured results show that has low capacitance about 310fF leakage current 12.2nA with suitable robustness target 5kV human body model.
This work presents a low-power low-cost CDR design for RapidIO SerDes. The is based on phase interpolator, which controlled by synthesized standard cell digital block. Half-rate architecture adopted to lessen the problems in routing high speed clocks and reduce power. An improved half-rate bang-bang detector presented assure stability of system. Moreover, paper proposes simplified control scheme interpolator further power cost. takes an area less than 0.05mm <sup...
In order to obtain power efficient flip-flops, two novel Hybrid-latch schemes are introduced in this paper. They achieve high performance by shortening the critical data path and efficiency eliminating inverter chain pulse generator. HSPCE simulation under SMIC 90nm process revealed that new flip-flop have excellent speed compared referenced design. can reduce 44.5% 51.4% dissipation, 29.2%and clock-to-output latency 65.6% 68.4% PDP.
A design of a 32-bit microprocessor core PKURS002 for embedded system is presented in this paper. It consumes much less power yet remains the high performance, compared with its prior PKURS001. The employs low techniques at controller, data path and internal memorial cells. controller distributed logic instead centralized one to reduce signal transition by enlarging self-loop. new algorithm LSA (Logarithmic Skip Adder) has been provided implement ALU bit-split technique applied structure...