A5101567551- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Analytical Chemistry and Chromatography
- Advancements in PLL and VCO Technologies
- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Radio Frequency Integrated Circuit Design
- Hydrogels: synthesis, properties, applications
- Microfluidic and Capillary Electrophoresis Applications
- Drug Transport and Resistance Mechanisms
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Photonic and Optical Devices
- Protein purification and stability
- Analytical Methods in Pharmaceuticals
- Amino Acid Enzymes and Metabolism
- Wound Healing and Treatments
- Biochemical effects in animals
- Fatigue and fracture mechanics
- Semiconductor Lasers and Optical Devices
- Hemoglobinopathies and Related Disorders
- High Temperature Alloys and Creep
- Drug-Induced Hepatotoxicity and Protection
Shenyang Pharmaceutical University
2015-2025
Beihang University
2023-2024
Tsinghua University
2022-2024
Aero Engine Corporation of China (China)
2024
Harbin Medical University
2015
University of Cincinnati
2011
Novel nanomaterials and advanced nanotechnologies prompt the fast development of new protocols for biomedical application. The unique light-to-heat conversion property nanoscale materials can be utilized to produce novel effective therapeutics cancer treatment. In particular, near-infrared (NIR) photothermal therapy (PTT) has gained popularity very quickly developed in recent years due minimally invasive treatments patients. This review summarizes current state-of-the-art inorganic...
Abstract A positive thermoresponsive hydrogel composed of poly(acrylic acid)‐ graft ‐β‐cyclodextrin (PAAc‐ g ‐β‐CD) and polyacrylamide (PAAm) was synthesized with the sequential interpenetrating polymer network (IPN) method for purpose improving its loading release drugs. The structure properties PAAc‐ ‐β‐CD/PAAm (IPN hydrogel) were characterized Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), swelling measurements. FTIR studies showed that IPN...
A new self-microemulsifying drug delivery system (SMEDDS) has been developed to increase the solubility, dissolution rate and oral bioavailability of tacrolimus (TAC). The formulations TAC-SMEDDS were optimized by solubility assay, compatibility tests, pseudo-ternary phase diagrams analysis. In order inhibit efflux P-glycoprotein (P-gp) for tacrolimus, which is substrate P-gp, excipients show inhibition effect such as tocopheryl polyethylene glycol succinate (TPGS) Cremophor EL40, chosen in...
Hydrogels are widely used in biomedical field such as wound healing, tissue adhesive and regeneration. with customized functions to meet the requirements of personalized medicine have increasingly become frontier clinical translation future. However, selecting appropriate functional materials design strategies optimize biological performance hydrogels still challenging. It requires integration network structure physical properties their performances. The situation will be more complicate...
The current 5G and future 6G high-speed mobile-Internet era puts forward stricter requirements on the power consumption, silicon area, phase noise specifications for local oscillators (LOs) in mobile portable devices, especially battery-powered phones, notebook computers, unmanned aerial vehicles (UAVs) used base stations. Over past few decades, intensive research to improve efficiency of RF millimeter-wave while maintaining required phase-noise characteristic has been carried out. As...
The purpose of this study was to investigate the influence structure and composition microemulsions (AOT/Tween85/isopropyl myristate/water) on their transdermal delivery potential a lipophilic model drug (Cyclosporin A), compare microemulsion suspension in normal saline containing 20% ethanol. Their type were examined by measuring surface tension, density, viscometry, electric conductivity; degree agreement between techniques assessed. Transdermal flux Cyclosporin A through rat skin...
Aim: The present study aimed at the development and characterisation of self-nanoemulsifying drug delivery system (SNEDDS) to improve oral bioavailability poorly soluble glyburide.Methods: solubility glyburide was determined in various oils, surfactants co-surfactants which were grouped into two different combinations construct ternary phase diagrams. formulations evaluated for emulsification time, droplet size, zeta-potential, electrical conductivity stability nanoemulsions.Result:...
Purpose: Supplementation of exogenous nerve growth factor (NGF) into the cochlea deafened animals rescues spiral ganglion cells from degeneration. However, a safe and potent delivery therapeutic proteins, such as NGF, to remains one greatest challenges. This study presents development self-assembled cubic lipid-based crystalline nanoparticles enhance inner ear bioavailability bioactive NGF via round window membrane route. Methods: A novel nanocarrier-entrapped was developed based on...
Objectives: This study investigated the impact of polymer excipients on a typical cocrystal for sacubitril (SAC) and valsartan (VAL), aiming to guide optional formulation design maximize oral bioavailability.Methods: Poly vinyl pyrrolidone (PVP) hydroxypropyl cellulose (HPC) methylcellulose (HPMC) were selected. The dissolution/permeation system was used predict both kinetics drug supersaturation simple permeation. intermolecular interaction analyzed by 1H NMR spectroscopy molecular dynamics...