A5101689863- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Spectroscopy and Chemometric Analyses
- Nanoparticle-Based Drug Delivery
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Hearing, Cochlea, Tinnitus, Genetics
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- ATP Synthase and ATPases Research
- Adrenal and Paraganglionic Tumors
- Ferroptosis and cancer prognosis
- Amino Acid Enzymes and Metabolism
- Cardiac tumors and thrombi
- Nutrition, Genetics, and Disease
- Pancreatitis Pathology and Treatment
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Thermal Expansion and Ionic Conductivity
Gaozhou People's Hospital
2021-2025
First Affiliated Hospital of Bengbu Medical College
2016-2024
Southern Medical University
2023-2024
Bengbu Medical College
2024
Guangxi Medical University
2024
Weifang People's Hospital
2021-2024
Jiujiang University
2023
National Institute for Occupational Health and Poison Control
2019-2023
Xintai People's Hospital
2020-2023
University of Benin
2023
Clinical sorafenib treatment could activate C-X-C receptor type 4 (CXCR4)/stromal source factor-1α (SDF-1α) axis to aggravate intra-tumoral hypoxia of hepatocellular carcinoma (HCC), which further leads progression, invasion, metastasis, and immunosuppression tumors in return causes resistance therapy. Therefore, a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane (PFH)-cored liposome, with the CXCR4 antagonist LFC131...
The revolutionary Proteolysis Targeting Chimera (PROTACs) have the exciting potential to reshape pharmaceutical industry landscape by leveraging ubiquitin-proteasome system for targeted protein degradation. Breast cancer, most prevalent cancer in women, could be treated using PROTAC therapy. Although substantial work has been conducted, there isn't yet a comprehensive overview or progress update on therapy breast cancer. Hence, this article, we've compiled recent research focusing different...
Aminoglycoside-induced hearing loss stems from damage or of mechanosensory hair cells in the inner ear. Intrinsic mitochondrial cell death pathway plays a key role that cellular dysfunction for which no proven effective therapies against oto-toxicities exist. Therefore, aim present study was to develop new targeting drug delivery system (DDS) provided improved protection gentamicin. Particularly, SS-31 peptide-conjugated geranylgeranylacetone (GGA) loaded poly(lactic-co-glycolic acid) (PLGA)...
Gastric cancer, one of the most common malignant tumors digestive tract, is devoid effective treatment owing to its highly invasive ability. Aquaporins (AQPs), transmembrane water channel proteins, has been shown be involved in malignancy gastric cancer. This study aims investigate pathophysiological roles AQP-1 We first demonstrated quantitative real-time polymerase chain reaction analysis and found up-regulation cancer cell lines. Additionally, silence inhibited proliferation via decrease...
Liposomes have made remarkable achievements as drug delivery vehicles in the clinic. Liposomal products mostly benefited from remote loading techniques that succeeded amphipathic and/or ionizable drugs, but seemed impracticable for nonionizable and poorly water-soluble therapeutic agents, thereby impeding extensive promising drugs to hitchhike liposomal disease therapy. In this study, a series of weak acid derivatives were designed by simplistic one step synthesis, which could be remotely...
TPP induced and GGA loaded mitochondria-targeting nanoparticles could efficiently protect hair cells from damage.
The developmental toxicity of gold nanoparticles with different shape in a zebrafish model was investigated and compared.
There is a paucity of mechanistic information on the DNA methylation and particulate matter (PM) exposure. This study aimed to investigate association PM its component with methylation, roles methyltransferase (DNMTs).There were 240 high-exposed, 318 low-exposed 210 non-exposed participants in this study. Individual concentrations PM, polycyclic aromatic hydrocarbons (PAHs) metals identified by monitoring data their workplaces. Urinary 1-OHP determined as exposure markers. The global (% 5mC)...
This research aimed to develop a rapid and nondestructive method model the growth discrimination of spoilage fungi, like Botrytis cinerea, Rhizopus stolonifer Colletotrichum acutatum, based on hyperspectral imaging system (HIS). A was used measure spectral response fungi inoculated potato dextrose agar plates stored at 28°C 85% RH. The were analyzed every 12 h over two days during growth, optimal simulation models built HIS parameters. results showed that coefficients determination (R2) for...
SS-31 modified, minocycline-loaded liposomes significantly increased hair cell survival against chronic exposure to gentamicin in a zebrafish model.
Hydroxyapatite (HA) was emerging as the most promising biomaterial owing to its excellent bioactivity, biocompatibility, and high compressive strength for segmental bone defects. However, due lack of synergistic signals osteogenic cells or growth factors, attempts concerning HA have not achieved an ideal therapeutical effect.This work intended combine particles with nerve factor (NGF) coaccelerate repair.To deal strong absorption on short half-life exogenous NGF, bovine serum albumin (BSA)...
One of the major challenges in treatment hearing loss is low efficacy therapeutic candidates. To achieve optimum drug efficacy, we designed a novel peptide (D-Arg-Dmt-Arg-Phe-NH2)-mediated mitochondrial targeted delivery nanosystem for promising candidate, geranylgeranylacetone (GGA). The zebrafish lateral line system, robust model mammalian hair cells, was used to identify against gentamicin, well-known ototoxic agent. facilitated lysosomal escape and accumulation, thus conferred superior...