A5101685777- Multiple Sclerosis Research Studies
- Carcinogens and Genotoxicity Assessment
- Traditional Chinese Medicine Analysis
- Microbial Metabolism and Applications
- Complementary and Alternative Medicine Studies
- Lower Extremity Biomechanics and Pathologies
- Genetically Modified Organisms Research
- Digital Imaging in Medicine
- Chemical synthesis and alkaloids
- Tendon Structure and Treatment
- Animal Virus Infections Studies
- Venous Thromboembolism Diagnosis and Management
- Multiple Myeloma Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Nephrotoxicity and Medicinal Plants
- Diagnosis and Treatment of Venous Diseases
- Forest, Soil, and Plant Ecology in China
- Infection Control and Ventilation
- Genomics, phytochemicals, and oxidative stress
- Extracellular vesicles in disease
- Respiratory Support and Mechanisms
- Advanced Breast Cancer Therapies
- Morphological variations and asymmetry
- Plant Physiology and Cultivation Studies
- Plant Ecology and Soil Science
Novartis (China)
2023-2024
Shanghai Jiao Tong University
2022-2024
Jiangsu University
2023
Saint Louis University
2023
Army Medical University
2022
Shihezi University
2021
Central Texas Veterans Health Care System
2020
Fujian Entry - Exit Inspection and Quarantine Bureau
2012
Northeast Forestry University
2010
Northwest University
2007
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we performed high-throughput enhanced yeast two-hybrid (HT-eY2H) screen to map interactome of all eight Ece1 peptides with their direct protein and identified list potential interacting proteins, some which were shared between peptides. CCNH, regulatory subunit CDK-activating kinase (CAK) complex...
Background: Ofatumumab has demonstrated superior efficacy and favorable safety for up to 2.5 years versus teriflunomide in relapsing multiple sclerosis (RMS). Objective: Further characterize of ofatumumab RMS. Methods: Efficacy set: patients randomized ofatumumab/teriflunomide ASCLEPIOS I/II (core). Safety who received ⩾ 1 dose I/II, APLIOS, APOLITOS (all core), or ALITHIOS (umbrella open-label extension). Patients continuous were newly switched from teriflunomide. Data cut-off: 25 September...
Coronavirus disease 2019 (COVID-19) was declared a serious global public health emergency. Hospitalization and mortality rates of lung cancer patients diagnosed with COVID-19 are higher than those presenting other cancers. However, the reasons for outcomes being disproportionately severe in adenocarcinoma (LUAD) remain elusive. The present study aimed to identify possible causes LUAD determine therapeutic target LUAD. We used publicly available data from Cancer Genome Atlas (TCGA) Gene...
Error-corrected next-generation sequencing (ecNGS) is an emerging technology for accurately measuring somatic mutations. Here, we report paired-end and complementary consensus (PECC-Seq), a high-accuracy ecNGS approach genome-wide mutation detection. We characterize novel 2-aminoimidazolone lesion besides 7,8-dihydro-8-oxoguanine the resulting end-repair artifacts originating from NGS library preparation that obscure accuracy of NGS. modify protocol enzymatic removal improve our previously...
A series of composite films poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) modified with polyvinylpyrrolidone (PVP) was prepared by varying the ratio constituents, and their properties cytocompatibility were evaluated. The hydrophilicity blended materials surfaces increased amounts fibronectin laminin adsorbed on surface remarkably compared PHBHHx. FT-IR spectra showed a new band, implying that physical interpenetrating network structure had formed. Scanning electron microscopy there...
The aim of this study was to identify significant changes in pedobarographic parameters attributed growth versus and surgical intervention for uninvolved feet, clubfeet (CF) subjected anterior tibialis tendon transfer surgery, unilateral nonsurgical CF. Participants underwent foot-pressure analysis preoperatively 3 years postoperatively. Six related the lateral midfoot showed increases CF, whereas CF surgery decreased. Transferring resulted improvements beyond typical a more balanced foot...
Background Epididymal leiomyosarcoma is an extremely rare tumor. In this study, we describe the sonographic features of uncommon Methods A case epididymal diagnosed at our institute was retrospectively analyzed. Ultrasonic images, noted clinical manifestations, treatment procedures, and pathology results were collected for patient. The same information from a systematic literature search on leiomyosarcoma, including PUBMED, Web Science Google Scholar databases. Results resulted in 12...
The physical and chemical properties of four kinds modified chitosan materials made by blending with polyvinylpyrrolidone (PVP) were investigated. All these hydrophilic water contact angles ranging from 59% to 69%. Fourier transform-infrared spectra the showed a new band at 1288 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> , implying formation surface interpenetrating network structure. Enzyme linked immunosorbent assay results...
Background: CO2 narcosis, often induced by injudicious use of oxygen and opioids, may result in ICU admission, intubation additional costs. The development is insidious. Currently, there no method for early detection.Methods: A retrospective cohort study patients with hypercapnia admitted between June 2013 2016 to a single hospital was performed. Presence pre-defined narcosis determined on chart review agreement two reviewers. Patients were divided into derivation validation groups, scoring...
Abstract Background: CDK4/6 inhibitors (CDK4/6i) paired with endocrine therapy (ET) are considered first-line (1L) for patients (pts) HR+ HER2- advanced breast cancer (aBC). A minority of pts will demonstrate primary resistance to CDK4/6i, as characterized by early progression. Thymidine kinase 1 (TK1) is a cell-cycle regulated enzyme downstream and involved in nucleotide metabolism during DNA synthesis. Prior studies have shown TK1 may serve biomarker response activity (TK1a) suppression...
<h3>Objective:</h3> To assess confirmed disability worsening (CDW), progression independent of relapse activity (PIRA), relapse-associated (RAW), and brain volume change (BVC) in relapsing multiple sclerosis patients receiving ofatumumab for up to 5 years. <h3>Background:</h3> In the ASCLEPIOS I/II core studies, (3-/6-month[m] CDW: 10.90%/8.15%) delayed accrual compared with teriflunomide (3/6mCDW: 14.98%/11.95%). PIRA was main contributor overall 3m/6mCDW. <h3>Design/Methods:</h3> Results...
Chose Nanyin Reservoir as the study object which located in southwestern Songnen Plain. The paper studied relationship of ecological environment and economic development between co-ordinations. Based on sustainable economics theory, combined Plain actual situation promoted strategies operational measures.
Phylogenetic inference-the derivation of a hypothesis for the common evolutionary history group species- is an active area research at intersection biology, computer science, mathematics, and statistics. One assumes data contains phylogenetic signal that will be recovered with varying accuracy due to quality method used, data. The input distance-based inference methods element Euclidean space coordinates indexed by pairs organisms. For several algorithms there exists subdivision this into...
<h3></h3> Confirmed disability worsening (CDW), progression independent of relapse activity (PIRA), relapse-as- sociated (RAW), and brain volume change (BVC) was assessed in relapsing multiple sclerosis patients receiving ofatumumab for up to 5 years from the ASCLEPIOS + ALITHIOS open-label extension Of 1882 randomized I/II (ofatumumab/teriflunomide:946/936), 1367 entered (continuous/switch:690/677). Most were free 3m/6mCDW events during studies (ofatu- mumab: 85.0%; teriflunomide: 80.7%)....
为评价电子烟气溶胶的遗传毒性，采用gpt delta转基因小鼠模型，以外周血网织红细胞为材料，通过微核试验检测电子烟气溶胶造成的染色体损伤作用，Pig-a基因突变试验检测电子烟气溶胶的致突变作用；以肺组织为材料，通过实时荧光定量PCR检测电子烟气溶胶对mmu-miR-34a、mmu-let-7a、Akt1、Il-6和Tnf-a基因表达的影响。结果表明：与对照组相比，电子烟气溶胶低、高剂量组和3R4F参比卷烟烟气低、高剂量组的微核率、Pig-a基因突变频率和网织红细胞百分比（RET%）差异均无统计学意义（P>0.05）。电子烟气溶胶低、高剂量组中mmu-miR-34a、Il-6和Tnf-a的表达均显著降低（P < 0.05），电子烟气溶胶高剂量组中mmu-let-7a的表达升高（P 0.05）。3R4F参比卷烟烟气高剂量组中mmu-miR-34a、mmu-let-7a和Tnf-a的表达均显著降低（P 0.05）。未检出电子烟气溶胶对gpt delta转基因小鼠有显著遗传毒性，但发现电子烟气溶胶显著影响DNA损伤和炎症相关基因的mRNA表达。
Abstract Background Ultraviolet (UV) light disinfection following a manual terminal cleaning process for hospital rooms has been proposed as an additional method to reduce the bacterial burden on surfaces. The impact of UV and level interdependence between modalities remains unclear. Methods Samples were collected from 5 high touch surfaces 10 patients room discharge prior disinfection, pulsed xenon using Rodac contact plates (total 150 samples). Colonies identified MALDI-TOF mass...