A5083277385- Bone fractures and treatments
- Foot and Ankle Surgery
- Lower Extremity Biomechanics and Pathologies
- Hip disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Tendon Structure and Treatment
- Cerebral Palsy and Movement Disorders
- Neurogenetic and Muscular Disorders Research
- Antifungal resistance and susceptibility
- Electromagnetic Fields and Biological Effects
- Diabetic Foot Ulcer Assessment and Management
- Elbow and Forearm Trauma Treatment
- Nerve injury and regeneration
- Prosthetics and Rehabilitation Robotics
- Orthopaedic implants and arthroplasty
- Genetic Neurodegenerative Diseases
- Fungal and yeast genetics research
- Botulinum Toxin and Related Neurological Disorders
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Mitochondrial Function and Pathology
- Neonatal and fetal brain pathology
- Spinal Fractures and Fixation Techniques
- Orthopedic Infections and Treatments
- Sarcoma Diagnosis and Treatment
Shriners Hospitals for Children Medical Center - Lexington
2014-2023
University of Kentucky
2013-2023
Shriners Hospitals for Children - Erie
2010-2020
American Orthotic and Prosthetic Association
2020
Lexington Clinic
2019
GTx (United States)
2011-2018
Walker (United States)
2011-2018
Lexington Medical Center
2018
Shriners Hospitals for Children
2015-2017
University of Aberdeen
2003-2015
Abstract Population genetics of the amphibian pathogen Batrachochytrium dendrobatidis ( Bd ) show that isolates are highly related and globally homogenous, data consistent with recent epidemic spread a previously endemic organism. Highly predicted to be functionally similar due low levels heritable genetic diversity. To test this hypothesis, we took global panel measured (i) relatedness among isolates, (ii) proteomic profiles (iii) susceptibility antifungal drug caspofungin, (iv) variation...
ABSTRACT Microbes must assimilate carbon to grow and colonize their niches. Transcript profiling has suggested that Candida albicans , a major pathogen of humans, regulates its assimilation in an analogous fashion the model yeast Saccharomyces cerevisiae repressing metabolic pathways required for use alterative nonpreferred sources when sugars are available. However, we show there is significant dislocation between proteome transcriptome C. . Glucose triggers degradation ICL1 PCK1...
Halo-gravity traction has been used preoperatively for patients with severe spinal deformity but there are limited data in the literature on results and complications. We studied outcomes of perioperative halo-gravity children deformity. A retrospective study was carried out who were treated at our center. Twenty-one included study. Radiographic pulmonary function parameters showed significant improvement during course final follow-up. The overall complication rate 19%, including two pin...
Considerable controversy exists in the orthopedic and neurosurgical literature over true incidence nature of spinal deformity after multiple-level cervical laminectomy children. Eighty-nine patients with a mean radiographic follow up 5.1 years (range 2-9 years) were reviewed. Mean age at surgery was 5.7 1 month-18 years). Most common diagnoses Arnold-Chiari malformation, syringomyelia, or both (81%). Significant developed 46 (53%), 33 developing kyphosis 30 degrees 5-105 degrees) 13...
Fractures of the body trapezium are uncommon. Ten such cases reported. They may be associated with other carpal or metacarpal fractures and require special radiographic views for diagnosis. There does not appear to a consistent mechanism injury. A classification system is proposed based on five fracture configurations identified. Open reduction internal fixation displaced articular surface preferred.
In Brief Study Design. Retrospective cohort study. Objective. To compare the efficacy of patient-controlled analgesia (PCA) with morphine alone, a single preoperative intrathecal injection and PCA (IT/PCA), epidural catheter infusion without (EPI) for postoperative pain control after posterior spinal fusion (PSF) segmental instrumentation (SSI) in adolescent idiopathic scoliosis (AIS). Summary Background Data. Postoperative PSF SSI AIS can be managed different ways. EPI provides longer...
Saccharomyces cerevisiae activates general amino acid control (GCN) in response to starvation. Some aspects of this are known be conserved other fungi including Candida albicans, the major systemic fungal pathogen humans. Here, we describe a proteomic comparison GCN responses S. and C. albicans. We have used high-resolution two-dimensional (2-D) gel electrophoresis peptide mass fingerprinting develop 2-D protein map A total 391 spots, representing 316 open reading frames, were identified....
The purpose of this study was to determine the effect clinically prescribed ankle-foot orthoses (AFOs) have on temporal-spatial parameters gait, as compared with barefoot walking in children cerebral palsy. A retrospective chart review data collected between 1995 and 1999 our motion analysis laboratory performed. 700 patients revealed 115 (mean age 9 years) who had a primary diagnosis CP (diplegia n=97, hemiplegia n=18). All were wearing hinged or solid AFOs at time undergoing three...
Background: Obesity as a cause of lower extremity deformity in children has been well established. This is most often seen tibia vara, however, at our institution we have observed more obese and adolescents over age 7 years with excessive or progressive idiopathic genu valgum. Our hypothesis that valgum high rates obesity which impact the severity their disease. Methods: Retrospective review existing data was performed on 66 consecutive children/112 limbs valgum, from 2010 to 2013. Children...
The treatment of clubfoot by the Ponseti method requires utilization a foot abduction orthosis (FAO) after manipulation and casting. Adherence to this protocol, specifically FAO wear rates, has been postulated improve outcomes. Our hypothesis was that caregiver-reported rates were significantly less than actual in these braces.A randomized prospective study 67 children, aged 0 3 years old with idiopathic clubfoot, treated using technique for undertaken IRB approval. Participants into groups:...
Renal cell carcinoma is the most common renal neoplasm associated with pregnancy. The presenting symptoms are pain and a palpable mass. Although neoplasms in pregnancy rare, demands special consideration methods of diagnostic evaluation. relationship between unclear. Treatment usually radical nephrectomy regardless stage Two new cases presented review literature.
The May issue of JRSM reports a further debate on public health in the UK 1 .As chest physician working Liverpool I am becoming increasingly frustrated by arguments around while my patients and are
Micro-organisms must adapt to environmental change survive, and this is particularly true for fungal pathogens such as Candida glabrata. C. glabrata found both in the environment diverse niches its human host. The ambient pH of these varies considerably, therefore we have examined response changes using a proteomic approach. Proteins expressed cells growing at 4.0, 7.4 or 8.0 were compared by 2-DE, 174 spots displaying reproducible statistically significant expression level identified...
Spinal deformity, a common problem in children with myelodysplasia, is associated alterations pulmonary function and sitting balance. Sitting imbalance causes areas of high pressure patients already at risk for developing ulcers due to insensate skin.We asked: Does spinal deformity affect tests myelodysplasia? the magnitude curvatures pelvic obliquity seating pressures? seated pressures correlate history ulcers?We retrospectively reviewed 32 myelodysplasia scoliosis (mean age, 14 years). The...
Pulsed electromagnetic fields (PEMF) have been shown to increase the rate of nerve regeneration. Transient post-transection loss target-derived growth factor (NGF) is one mechanism proposed signal induction early regenerative events. We tested hypothesis that PEMF alter levels NGF activity and protein in injured and/or dorsal root ganglia (DRG) during first stages regeneration (6–72 hr). Rats with a transection injury midthigh portion sciatic on side were exposed or sham control for 4 hr/day...
Background: Fibular deficiency results in a small, unstable foot and ankle as well limb-length discrepancy. The purpose of this study was to assess outcomes adults who, children, had amputation or limb-lengthening, commonly used treatments for fibular deficiency. Methods: Retrospective review existing data collected since 1950 at six pediatric orthopaedic centers identified 248 patients with who were twenty-one years age older the time review. Excluding other anomalies (with excluded group...
Ponseti serial casting is the most commonly used method in North America to treat children with clubfeet. Despite initial correction, recurrence common. tibialis anterior tendon transfer (TATT) recurrent Recurrence can occur after TATT, and patients at risk of may benefit from closer monitoring. We studied rate second (recurrence TATT) predictive factors for this recurrence.Retrospective chart review who have undergone TATT clubfeet between 2002 2010 our institution was performed. defined as...
The purpose of this study was to determine the frequency with which postoperative radiographs resulted in a change management following closed reduction and percutaneous pinning displaced pediatric supracondylar humerus fractures. We hypothesize that only initial radiograph will lead changes operative fractures.A retrospective review performed at 2 level I trauma centers. Inclusion criteria were patients below 18 years age who sustained fractures (Gartland type II, III, IV) operatively...
Abstract Electromagnetic fields (EMFs) have been demonstrated to enhance mammalian peripheral nerve regeneration in vitro and vivo. Using an EMF signal shown neurite outgrowth vitro, we tested this field vivo using three different amplitudes. The rat sciatic was crushed. Whole body exposure performed for 4 h/day 5 days a 96‐turn solenoid coil controlled by generator power amplifier. induced electric at the target tissue consisted of bipolar rectangular pulse, having 1 0.3 ms durations each...