A5100395255- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Radiopharmaceutical Chemistry and Applications
- Cancer-related Molecular Pathways
- Computational Drug Discovery Methods
- Hormonal and reproductive studies
- Neuroscience and Neuropharmacology Research
- Mass Spectrometry Techniques and Applications
- Mesenchymal stem cell research
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Skin Protection and Aging
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Diet, Metabolism, and Disease
- Growth Hormone and Insulin-like Growth Factors
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
University of Rhode Island
2021-2025
Shihezi University
2023-2025
State Key Laboratory of Oncology in South China
2024
Sun Yat-sen University Cancer Center
2020-2024
Sun Yat-sen University
2020-2024
Nankai University
2022-2024
Wuhan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Zhongnan Hospital of Wuhan University
2024
Sichuan University
2015-2023
The programmed cell death 1 (PD-1) immune checkpoint of co-inhibitory signaling plays crucial roles in controlling the magnitude and duration T activation to limit tissue damage maintain self-tolerance. Cancer cells hijack pathway escape surveillance by overexpressing PD-1 ligand PD-L1. Immune inhibitors, such as blocking antibody have been approved for tumor immunotherapy. However, not all patients can benefit from monotherapy. Combination immunotherapy based on axis blockade substantially...
Malignant astrocytomas (MA) are aggressive central nervous system tumors with poor prognosis. Activating mutation of BRAF (BRAF(V600E)) has been reported in a subset these tumors, especially children. We have investigated the incidence BRAF(V600E) additional pediatric patient cohorts and examined effects blockade preclinical models wild-type MA.BRAF(V600E) status was two MA cohorts. For functional studies, cell lines were used to investigate shRNA knockdown vitro, pharmacologic inhibition...
The human androgen receptor (AR) is considered as a master regulator in the development and progression of prostate cancer (PCa). As resistance to clinically used anti-AR drugs remains major challenge for treatment advanced PCa, there pressing need new therapeutic avenues. In this study, we identified binding site on DNA domain (DBD) utilized virtual screening discover set micromolar hits target. Through further exploration most potent hit (1), structural analogue (6) was demonstrating...
Abstract Although mRNA vaccines are known as potent activators of antigen-specific immune responses against infectious diseases, limited understanding how they drive the functional commitment CD8 + T cells in tumor microenvironment (TME) and secondary lymphoid organs hinders their broader application cancer immunotherapy. Here, we systematically evaluated immunological effects a lipid nanoparticle (LNP)-encapsulated vaccine that encodes human papillomavirus E7 protein (HPV mRNA-LNP),...
Neurons that reenter a cell cycle after maturation are at increased risk for death, yet the mechanisms by which normal neuron suppresses remain mostly unknown. Our laboratory has shown cyclin-dependent kinase 5 (Cdk5) is potent suppressor, and we report here on molecular basis of this activity. Cell suppression Cdk5 requires its binding to p35 activator protein. The related p39 p25 proteins cannot serve as substitutes. Unexpectedly, enzymatic activity not required perform function. Rather,...
The human androgen receptor (AR) is a proven therapeutic target in prostate cancer. All current antiandrogens, such as Bicalutamide, Flutamide, Nilutamide, and Enzalutamide, the buried hydrophobic binding pocket of this protein. However, effective resistance mechanisms against these therapeutics exist mutations occurring at site. To overcome limitations, surface AR called function 3 (BF3) was characterized an alternative for small molecule therapeutics. A number inhibitors directly targeting...
To overcome resistance to conventional anti-androgens of human androgen receptor (AR), the allosteric site AR binding function 3 (BF3) was investigated as an alternative target for small molecule therapeutics. A library 1H-indole-2-carboxamides were discovered BF3 inhibitors and exhibited strong antiproliferative activity against LNCaP enzalutamide-resistant prostate cancer cell lines. Several lead compounds may prove particular benefit a novel treatment castration-resistant cancers.
This study estimates the prevalence of five chronic non-communicable disease (NCDs) (hypertension, diabetes, CHD, COPD and stroke) its multimorbidity, examines relationship between SES lifestyle factors multimorbidity among older adults in rural southwest China.A cross-sectional survey 4833 consenting aged ≥60 years was conducted 2017. Data on demographics, smoking, drinking, height, weight, blood pressure fasting glucose were collected.Among participants, overall hypertension, stroke, CHD...
Abstract Background Diabetes has become a major public health problem in China. A better understanding of diabetes determinants and urban-rural differences is essential to crafting targeted prevention measures for the elderly living both urban rural areas. This study aimed compare rural-urban differentials prevalence lifestyle pre-diabetes among southwest Methods cross-sectional interview examination survey was conducted individuals aged ≥ 60 years area Anthropometric measurements, including...
Oleuropein is a phenolic compound commonly found in cosmetic ingredients including olive leaves and jasmine flowers with various skin-beneficial effects. Here, we evaluated oleuropein's anti-inflammatory antioxidant activities human skin cells. In cell-based inflammasome model monocytes (THP-1 cells), oleuropein (12-200 µM) reduced proinflammatory cytokine interleukin (IL)-6 by 38.8%-45.5%, respectively. (50 100 also alleviated oxidative stress keratinocytes (HaCaT cells) reducing...
Triple-negative breast cancers (TNBC) are notoriously difficult to treat because they lack hormone receptors and have limited targeted therapies. Recently, we demonstrated that p90 ribosomal S6 kinase (RSK) is essential for TNBC growth survival indicating it as a target therapeutic development. RSK phosphorylates Y-box binding protein-1 (YB-1), an oncogenic transcription/translation factor, highly expressed in (~70% of cases) associated with poor prognosis, drug resistance tumor initiation....
As a cyclin-independent atypical CDK, the role of CDK5 in regulating cell proliferation gastric cancer remains unknown.
CDK5, an atypical member of the CDK family, play a significant role in tumorigenesis multiple organ, but CDK5 and its substrates genesis development HCC is still unclear. Expression tumor paired adjacent noncancerous tissues from 90 patients were measured by Western blotting, immunohistochemistry, real-time PCR. The cell function was explored lines, ex vivo xenografts diethylnitrosamine induced model. Furthermore, comparative phosphoproteomic screening identified oncoprotein TPX2 as new...
Nitric oxide (NO), as a gaseous therapeutic agent, shows great potential for the treatment of many kinds diseases. Although various NO delivery systems have emerged, immunogenicity and long-term toxicity artificial carriers hinder clinical translation these gas therapeutics. Mesenchymal stem cells (MSCs), with capacities self-renewal, differentiation, low immunogenicity, been used living carriers. However, MSCs signaling molecule (GSM) not reported. In this study, human were genetically...
Skin cells are susceptible to oxidative stress and various types of cell death, including an iron-dependent form known as ferroptosis. Cannabidiol (CBD) can protect skin against stress, but whether this is attributed the inhibition ferroptosis unknown. Herein, we evaluated anti-ferroptotic effect CBD in human keratinocytes using biochemical assays (radical scavenging iron chelating) cell-based models (for lipid peroxidation intracellular iron). CBD's was further characterized by proteomic...
Previous studies have highlighted the antitumor effects of mesenchymal stem cell‑derived extracellular vesicles (MSC‑EVs), positioning them as a promising therapeutic avenue for cancer treatment. However, some researchers proposed bidirectional influence MSC‑EVs on tumors, determined by specific tissue origin MSCs and types tumors involved. The present study aimed to elucidate human placenta MSC‑derived (hPMSC‑EVs) malignant behavior mouse breast model 4T1 cells
Limited studies are available on the molecular pathogenesis of Epstein-Barr virus (EBV)-associated T or natural killer (NK) cell lymphoproliferative disorders (EBV+T/NK-LPD). In this retrospective study, we aim to elucidate mutation profile EBV+T/NK-LPD using capture-based targeted sequencing with a panel consisting 64 lymphoma-related genes identify driver associated development EBV+T/NK-LPD. Targeted 169 cases was performed genes. Of cases, 123 had extra-nodal NK/T-cell lymphoma (ENKTL),...