A5100425743- Ginseng Biological Effects and Applications
- Lung Cancer Treatments and Mutations
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Traditional Chinese Medicine Analysis
- Natural Compound Pharmacology Studies
- Erythropoietin and Anemia Treatment
- Cyclopropane Reaction Mechanisms
- Healthcare and Venom Research
- Click Chemistry and Applications
- Ubiquitin and proteasome pathways
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Ziziphus Jujuba Studies and Applications
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Carbohydrate Chemistry and Synthesis
- Catalytic Alkyne Reactions
- Liver Disease Diagnosis and Treatment
- Galectins and Cancer Biology
- Chemical Synthesis and Analysis
- Bioactive natural compounds
Chengdu University of Traditional Chinese Medicine
2020-2025
South China University of Technology
2025
Guangzhou Medical University
2025
Guangzhou First People's Hospital
2025
Chinese PLA General Hospital
2023-2025
State Key Laboratory of Kidney Diseases
2025
Tianjin Medical University
2022-2025
Shanghai University of Traditional Chinese Medicine
2016-2024
Shanghai East Hospital
2023-2024
Beijing Fengtai Disease Prevention and Control Center
2022-2024
Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting fully substituted
The catalytic activity of a series ruthenium(II) complexes in azide-alkyne cycloadditions has been evaluated. [Cp*RuCl] complexes, such as Cp*RuCl(PPh 3) 2, Cp*RuCl(COD), and Cp*RuCl(NBD), were among the most effective catalysts. In presence 2 or primary secondary azides react with broad range terminal alkynes containing functionalities selectively producing 1,5-disubstituted 1,2,3-triazoles; tertiary significantly less reactive. Both also promote cycloaddition reactions organic internal...
The importance of cross-talk between a cancer and its microenvironment has been increasingly recognized. We hypothesized that mutational inactivation the tumor-suppressor gene TP53 genomic alterations in stromal cells tumor's contribute to clinical outcome.We performed mutation analysis genomewide loss heterozygosity allelic imbalance on DNA from isolated neoplastic epithelial 43 patients with hereditary breast 175 sporadic cancer. Compartment-specific patterns mutations were analyzed....
Chinese date, the fruit of Ziziphus jujuba Mill., has thousands years cultivation history, and about 700 cultivars dates in China. Two types are commonly found market: (i) fresh immature consumed as fruits, (ii) dried mature used medicines. Here, chemical biological properties these were revealed. Different sources showed similar profiles; however, amounts identified chemicals a great variation. The amount nucleotides, flavonoids polysaccharides could be affected by its maturity drying...
Abstract Co-delivery of microRNAs and chemotherapeutic drugs into tumor cells is an attractive strategy for synergetic breast cancer therapy due to their complementary mechanisms. In this work, a core-shell nanocarrier coated by cationic albumin was developed simultaneously deliver miRNA-34a docetaxel (DTX) improved therapeutic effect. The co-delivery nanocarriers showed spherical morphology with average particle size 183.9 nm, they efficiently protected from degradation RNase serum....
Radix Astragali (RA) is commonly used as a health food supplement to reinforce the body vital energy. Flavonoids, including formononetin, ononin, calycosin, and calycosin-7-O-β-d-glucoside, are considered be major active ingredients within RA. Here, we provided different lines of evidence that RA flavonoids stimulated expression erythropoietin (EPO), central regulator red blood cell mass, in cultured human embryonic kidney fibroblasts (HEK293T). A plasmid containing hypoxia response element...
An amphiphilic hyaluronic acid (HA)-g-all-trans retinoid (HRA) conjugate was successfully developed as a tumor-targeting nanocarrier for potentially synergistic combination chemotherapy of all-trans (ATRA) and paclitaxel (PTX). The HRA synthesized by an imine reaction between HA-COOH ATRA-NH2. PTX-loaded nanoparticles possessed high loading capacity, nanoscale particle sizes, good biocompatible characteristics. Cell viability assays indicated that exhibited concentration- time-dependent...
Abstract Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary substantially. In particular, the of coagulation proteases (pM to nM) are much lower than their natural inactivator antithrombin (AT, ~ 3 μM), suggesting existence other coordinators. current study, we found that transferrin (normal plasma concentration ~40 μM) interacts with fibrinogen, thrombin, factor XIIa (FXIIa), and AT different affinity maintain...
To evaluate the anti-diabetic effect of Fritillaria cirrhosa gold nanoparticles on Streptozotocin (STZ) stimulated diabetic preclinical models. The albino rats either sex were equally distributed to five different groups. Group-I represented as Control; Group-II control (STZ alone); Group-III 10 mg/kg body weight + diabetes; Group-IV 20 Group-V 0.1 glibenclamide diabetes. animals killed after experimental period. blood and organs samples gathered stored for additional investigations....
The present study evaluated the predictive ability of five known "best" obesity and lipid-related parameters, including body mass index (BMI), waist-to-height ratio (WHtR), triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C), lipid accumulation product (LAP) visceral adiposity (VAI), in identifying metabolic syndrome (MetS) Chinese elderly population. A total 6722 subjects (≥60 years) were recruited into our community-based cross-sectional from April 2015 to July 2017....
Non-small-cell lung cancer (NSCLC) has been recognized as a highly heterogeneous disease with phenotypic and genotypic diversity in each subgroup. While never-smoker patients NSCLC have well studied through next generation sequencing, we yet to recognize the potentially unique molecular features of young NSCLC. In this study, conducted whole genome sequencing (WGS) characterize genomic alterations 36 Chinese patients, who were diagnosed adenocarcinoma (LUAD) at 45 years or younger. Besides...
Macrophages play important roles in immunity and other physiological processes. They are also target cells of various toxic agents, including oxidants electrophiles. However, little is known regarding the molecular regulation chemical inducibility a spectrum endogenous antioxidants phase 2 enzymes normal macrophages. Understanding pathway(s) controlling coordinated expression macrophage defenses importance for developing strategies to protect against injury induced by Accordingly, this study...
Diabetes mellitus is associated with decreased NO bioavailability in the myocardium. Ginsenoside Rb1 has been shown to confer cardioprotection against ischemia reperfusion injury. The aim of this study was investigate whether exerts cardioprotective effects during myocardial ischemia-reperfusion diabetic rats and effect related increase production via enhancing eNOS expression I/R injury were induced by occluding left anterior descending artery for 30 min followed 120 reperfusion. An...
The purpose of this study was to develop an efficient dual-ligand based liposomal drug delivery system with targeting specificity as well properties that would kill melanoma cells. Liposomes modified transferrin (Tf) and cell-penetrating peptide TAT prepared, which encapsulated two kinds chemotherapy drugs, paclitaxel doxorubicin (Tf/TAT-PTX/DOX-LP). Tf ligands specifically bind the overexpressed receptors on surface cells, while functioned a classical cell penetrating peptide, helping...
The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed a health supplement herbal medicine worldwide. To study the beneficial role in regulating immune response, we investigated its roles on expressions pro‐inflammatory cytokines cultured macrophages. Application chemically standardized water extract for 24 h stimulated transcriptional expression interleukin (IL)‐1β, IL‐6, and tumor necrosis factor (TNF)‐α RAW 264.7 In contrast, pretreatment with suppressed...