A5100337882- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Trauma and Emergency Care Studies
- Case Reports on Hematomas
- Histone Deacetylase Inhibitors Research
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Retinoids in leukemia and cellular processes
- Eosinophilic Disorders and Syndromes
- Video Analysis and Summarization
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Gestational Diabetes Research and Management
- Advanced Image and Video Retrieval Techniques
- Antioxidant Activity and Oxidative Stress
- Computational Drug Discovery Methods
- Abdominal Trauma and Injuries
- Pregnancy and preeclampsia studies
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
Dalian Institute of Chemical Physics
2016-2025
Chinese Academy of Sciences
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Sanya University
2024
Tianjin University of Traditional Chinese Medicine
2024
Medical Center Hospital
2024
Xi’an International University
2024
Dalian University of Technology
2021-2024
Moffitt Cancer Center
2024
Shandong Maternal and Child Health Hospital
2023
Abstract The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has been demonstrated to have comparable effectiveness or better ATRA chemotherapy (CHT) in non-high-risk acute promyelocytic leukemia (APL). However, the efficacy ATRA-ATO compared plus CHT high-risk APL remains unknown. Here we performed a randomized multi-center non-inferiority phase III study compare newly diagnosed all-risk address this question. Patients were assigned receive for induction,...
Abstract Background Diabetes has become a major public health problem in China. A better understanding of diabetes determinants and urban-rural differences is essential to crafting targeted prevention measures for the elderly living both urban rural areas. This study aimed compare rural-urban differentials prevalence lifestyle pre-diabetes among southwest Methods cross-sectional interview examination survey was conducted individuals aged ≥ 60 years area Anthropometric measurements, including...
The human serum albumin (HSA)-drug binding characteristic is directly related to the pharmacokinetic, pharmacodynamic profile and side effect properties of drug. Though much known about protein characteristics flavonol, influence molecular structure flavonol dynamic behaviour conformations have received little attention. Here, we studied interactions HSA with flavonols by using docking, dynamics simulations coupled mechanics- Poisson Boltzmann/generalized Born surface area (MM-PB/GBSA)...
Optimizing olverembatinib dose in people with chronic phase myeloid leukemia (CML) is important to increase safety without compromising efficacy. We designed a multi-center retrospective study comparing and efficacy of between the recommended 40 mg every other day (QOD; N = 216) reduced 30 QOD (N 66) subjects failing tyrosine kinase-inhibitors (TKIs). The cohorts were similar baseline co-variates adjusted for by propensity score matching (PSM). There no significant differences cytogenetic...
Metabolomics has shown significant potential in identifying small molecules specific to tumor phenotypes. In this study we analyzed resected tissue metabolites using capillary electrophoresis-mass spectrometry and found that hypotaurine levels strongly positively correlated with glioma grade. vitro studies were conducted show activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads activation as well enhancement cell proliferation invasion....
A novel, precise, and accurate high-performance liquid chromatography-tandem mass spectrometry (Q-trap-MS) method was developed, optimized, validated for determination of vancomycin in human serum using norvancomycin as an internal standard. Effect different parameters on the analysis evaluated. ZORBAX SB-C18 column (150 × 4.6 mm, 5 μm) water (containing 0.1% formic acid, v/v)⁻acetonitrile v/v) a mobile phase chosen. The calibration curve linear over concentration ranges 1 to 2000 ng/mL...
Lung cancer remains the leading cause of death worldwide, and current therapy seems to have reached a plateau due toxicities acquired resistance. Therefore, exploration novel therapeutic avenues may be useful. Si Jun Zi Tang (SJZ), four-herb Chinese medicine formula first described approximately one thousand years, is often prescribed for patients as complementary therapy. However, whether SJZ benefits well main active constituents its regulatory mechanism in combination with anticancer...
Objective: The aim was to examine the effects of Na+/H+ exchange inhibitors amiloride and methylisobutyl (MIA) in buffer perfused rabbit hearts subjected one hour normothermic ischaemia (37 °C) followed by reperfusion. Methods: Experiments were carried out five groups Langendorff hearts: (1) control, (2) amiloride, (3) MIA (agents both preischaemic reperfusion perfusate), (4) amiloride-R (5) MIA-R added at only). Functional evaluation included serial measurement resting tension, force, rates...
Abstract Although tyrosine kinase inhibitor (TKI) therapy has markedly improved the survival of people with chronic-phase chronic myeloid leukemia (CML), 20% to 30% still experienced failure. Data from 1955 consecutive patients CML diagnosed by European LeukemiaNet recommendations 1 center receiving initial imatinib or a second-generation (2G) TKI were interrogated develop clinical prediction model for TKI-therapy This was subsequently validated in 3454 76 other centers. Using predictive...
The purine contents of alcoholic beverages are usually quantified by high-performance liquid chromatography coupled with a UV detector and preceded hydrolyzing samples perchloric acid. In this article, we have developed an improved hydrolysis procedure in which sulfuric acid is used as the reagent. Through experiments under different conditions, established optimum sample pretreatment technique. This whole method enables four bases (namely, guanine, adenine, hypoxanthine, xanthine) beer to...
Genetic studies have revealed that rare mutations and multiplications of the gene locus in α-synuclein (α-syn) are implicated pathogenesis Parkinson's disease (PD). However, pathological effects α-syn still obscure. The neurotoxicity is mainly determined by its protein levels, which depend on a balance between synthesis degradation. Therefore, verifying possible routes contributing to clearance important for PD therapy. In this study, we established stable lines overexpressing human...