A5100380396- RNA modifications and cancer
- Natural product bioactivities and synthesis
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Lipid Membrane Structure and Behavior
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive Natural Diterpenoids Research
- Phytochemical compounds biological activities
- Cancer-related molecular mechanisms research
- Toxin Mechanisms and Immunotoxins
- Nanopore and Nanochannel Transport Studies
- Marine Sponges and Natural Products
- Ion channel regulation and function
- Transgenic Plants and Applications
- Spectroscopy and Quantum Chemical Studies
- Phytochemistry and Biological Activities
- Photosynthetic Processes and Mechanisms
- Fungal Plant Pathogen Control
- Microbial Natural Products and Biosynthesis
- Berberine and alkaloids research
- Drug Transport and Resistance Mechanisms
- Alkaloids: synthesis and pharmacology
- Bacteriophages and microbial interactions
- Traditional and Medicinal Uses of Annonaceae
- Hybrid Renewable Energy Systems
Chinese Academy of Sciences
2013-2025
Dalian Institute of Chemical Physics
2016-2025
Guiyang College of Traditional Chinese Medicine
2025
Guizhou University
2025
Dalian National Laboratory for Clean Energy
2024
University of Chinese Academy of Sciences
2021
Dalian University
2021
Dalian University of Technology
2021
Sun Yat-sen University
2020
Sun Yat-sen University Cancer Center
2020
Classical molecular dynamic (MD) simulation of membrane proteins faces significant challenges in accurately reproducing and predicting experimental observables such as ion conductance permeability due to its incapability precisely describing the electronic interactions heterogeneous systems. In this work, free energy profiles K+ Na+ permeating through gramicidin A channel are characterized by using AMOEBA polarizable force field with a total sampling time 1 μs. Our results indicated that...
The human serum albumin (HSA)-drug binding characteristic is directly related to the pharmacokinetic, pharmacodynamic profile and side effect properties of drug. Though much known about protein characteristics flavonol, influence molecular structure flavonol dynamic behaviour conformations have received little attention. Here, we studied interactions HSA with flavonols by using docking, dynamics simulations coupled mechanics- Poisson Boltzmann/generalized Born surface area (MM-PB/GBSA)...
Melanoseris, a diverse genus in the Lactucinae subtribe, has 21 species China, with 13 being endemic. The high diversity of this presents taxonomic challenges, particularly M. cyanea group, where overlapping distributions and transitional morphological traits complicate classification. This study aims to analyze chloroplast genomes focus on explore structural differences phylogenetic relationships among these closely related species. We analyzed 16 Melanoseris samples, including 12 new from...
purpose. Brief periods of ischemia have been shown to protect the retina from potentially damaging ischemia. This phenomenon has termed ischemic preconditioning or tolerance. In present study cellular changes in levels heat shock protein (Hsp)27, -70, and -90 mRNA expression Hsp rat associated with were evaluated. methods. Unilateral retinal was created Long-Evans Sprague-Dawley rats for 5 minutes. Rats then left 1 hour 7 days, allow reperfuse. Retinas dissected, isolated, Northern Western...
A novel segetane diterpenoid (1) and four jatrophane diterpenoids (2–5) were isolated from an acetone extract of Euphorbia peplus. Due to quantity limitations, we prepared 1 via a Diels–Alder reaction, approach motivated by this compound's biosynthetic pathway successfully performed X-ray analysis 1. Furthermore, in vitro activity test, exhibited moderate anti-inflammatory activity, whereas both its precursor (2) the relevant intermediate (2a, IC50 = 1.56 μM) significant activity.
Phytochemical investigation of the aerial parts monotypic plant, Musella lasiocarpa, led to isolation four rare bicyclic diarylheptanoids, musellarins B-E (2–5), two new phenylphenalenones, 2-methoxy-9-(3′,4′-dihydroxyphenyl)-1Hphenalen-1-one (9), 2-methoxy-9-(3′-methoxy-4′-hydroxyphenyl)-1H-phenalen-1-one (10), a acenaphtylene derivative, trans-(1S,2S)-3-(4′-methoxyphenyl)-acenaphthene-1,2-diol (13), and sucrose esters, 1,2′,3′,4′,6′-O-pentaacetyl-3-O-trans-pcoumaroylsucrose (16),...
Eleven new limonoids, turrapubins A–K (1–11), and three triterpenoids (12–14), along with 14 known compounds, were isolated from the twigs of Turraea pubescens. The structures 1–14 elucidated on basis NMR MS analysis. Compounds 12, 16, 18, 19 exhibited inhibitory activities against lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. In addition, compounds 2, 11, 26 brine shrimp larvae (Artemia salina) at 100 ppm corrected mortality ranging 81.7% to 100%.
The first chemical study of an Actinocyclidae nudibranch, Actinocyclus papillatus, resulted in the isolation (−)-actisonitrile (1), a lipid based on 1,3-propanediol ether skeleton. structure was established by spectroscopic methods, whereas absolute configuration chiral center determined comparing optical properties natural actisonitrile with those (+)- and (−)-synthetic enantiomers, opportunely prepared. Both (−)- (+)-actisonitrile were tested preliminary vitro cytotoxicity bioassays tumor...
A new bis-1-oxaquinolizidine alkaloid, 9′-epi-3β,3′β–dimethylxestospongin C (2), and three known related analogues have been isolated from the Hainan sponge Neopetrosia exigua.
A series of novel perbutyrylated glycosides 4β-triazolopodophyllotoxin derivatives were synthesized by utilizing the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. Evaluation cytotoxicity against a panel five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assay shows that some these glycosylated have good anticancer activity. Among compounds, compound 21a highest activity, with IC50 values ranging from 0.49 to 6.70 μM, which is more potent than...
In all of the classical force fields, electrostatic interaction is simply treated and explicit electronic polarizability neglected. The condensed-phase polarization, relative to gas-phase charge distributions, commonly accounted for in an average way by increasing atomic charges, which remain fixed throughout simulations. Based on lipid polarizable field DMPC following same framework as Atomic Multipole Optimized Energetics BiomoleculAr (AMOEBA) simulation, present effort expands new anionic...
Total phenols, flavonoids, minerals content and amino acids were investigated in four fern species grown under shading treatments with different transmittance of 35% full sunlight (FS), 13% FS, 8% FS 4% FS. The contain high levels total phenols as well abundant mineral elements acids. strongly affected by transmittance, the flavonoids significantly positively correlated negatively transmittance. Higher light intensity can effectively stimulate synthesis flavonoid, proper accumulation In...
Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, molecular mechanism by which it acts remains unknown. The aim this study to investigate effect acetaminophen on inflammation and extracellular matrix degradation in human chondrocytes, possible mechanisms involved its effect.The normal chondrocyte cell line C28/I2 was treated with interleukin-1β mimic inflammatory state. methylation inhibitor (cycloleucine) were used treat interleukin-1β-induced cells....
Abstract Alcohols carbonylation is of great importance in industry but remains a challenge to abandon the usage halide additives and noble metals. Here we report realization direct alcohols heterogeneous carbonyl‐containing chemicals, especially methanol carbonylation, with remarkable space‐time‐yield (STY) 4.74 mol acetyl /kg cat. /h durable stability as long 100 h on Ni@MoS 2 catalyst. Mechanistic analysis reveals that Mo−Ni dual sites localized at edge sulfur vacancies exhibit distinct...