A5084271825- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Protein Structure and Dynamics
- Lipid Membrane Structure and Behavior
- Enzyme Structure and Function
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Urinary Bladder and Prostate Research
- Inflammatory Bowel Disease
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Asymmetric Hydrogenation and Catalysis
- RNA modifications and cancer
- Ion channel regulation and function
- Graphene and Nanomaterials Applications
- Nanomaterials for catalytic reactions
- Surface Chemistry and Catalysis
- Carbon dioxide utilization in catalysis
- Rheumatoid Arthritis Research and Therapies
- Supramolecular Chemistry and Complexes
- Photodynamic Therapy Research Studies
- Wound Healing and Treatments
- Catalysis for Biomass Conversion
Army Medical University
2015-2025
Southwest Hospital
2019-2024
Dalian Institute of Chemical Physics
2012-2021
Chinese Academy of Sciences
2012-2021
University of Chinese Academy of Sciences
2020-2021
Dalian University
2020-2021
Dalian University of Technology
2021
Aerospace Center Hospital
2020
Harbin Engineering University
2020
State Key Laboratory of Molecular Reaction Dynamics
2020
Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based applications are limited depth tissue penetration, inevitable requirement external irradiation, poor biocompatibility nanoparticles. To overcome these critical limitations, we synthesized a sensitive, specific, biodegradable luminescent nanoparticle that is self-assembled from an amphiphilic polymeric conjugate with donor...
A novel reactive oxygen species (ROS)-responsive nanoplatform can be successfully manufactured from a ROS-triggerable β-cyclodextrin material. Extensive in vitro and vivo studies validate that this nanoscaled system may serve as new drug delivery vehicle with well-defined ROS-sensitivity superior biocompatibility. This nanocarrier used for ROS-triggered transport of diverse therapeutics imaging agents. As service to our authors readers, journal provides supporting information supplied by the...
Immunocompromised individuals and those with lung dysfunction readily acquire pulmonary bacterial infections, which may cause serious diseases carry a heavy economic burden. Maintaining adequate antibiotic concentrations in the infected tissues is necessary to eradicate resident bacteria. To specifically deliver therapeutics enable controlled release of payloads at infection site, ROS-responsive material, i.e. 4-(hydroxymethyl) phenylboronic acid pinacol ester-modified α-cyclodextrin...
To develop reactive oxygen species (ROS)-responsive anti-inflammatory materials and establish their structure–property correlations, a series of H2O2-eliminating (OxbCDs) were designed synthesized by conjugating different phenylboronic acid pinacol ester (PBAP) groups onto biocompatible scaffold compound β-cyclodextrin via varied linker groups. Both the H2O2-triggered hydrolysis profiles capacities these dependent on chemical structure PBAP moieties. Together with elucidation mechanisms, we...
The PD-1/PD-L1 pathway in mucosal immunity is currently actively explored and considered as a target for inflammatory bowel disease (IBD) treatment. However, systemic PD-L1 administration may cause unpredictable adverse effects due to immunosuppression. Here we show that reactive oxygen species (ROS)-responsive nanoparticles enhance the efficacy safety of mouse colitis model. control accumulation release fused Fc (PD-L1-Fc) at sites colon. nanotherapeutics shows superiority alleviating...
Manganese dioxide (MnO
Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated characterized via mannose (Man) modification. NPs exhibit significant inhibitory activity against extra- MRSA obviously decrease minimum concentration Van. can be...
Although stimuli-responsive nanoplatforms were developed to deliver immunogenic cell death (ICD) inducers enhance cancer immunotherapy, the complete release of ICD into tumor microenvironment (TME) was limited by inadequate supplementation endogenous stimulus (e.g., reactive oxygen species (ROS)). To address this issue, we synthesized a self-responsive nanomaterial with self-supplied ROS, which mainly consists ROS responsive moiety HPAP and cinnamaldehyde (CA) as ROS-generating agent. The...
Classical molecular dynamic (MD) simulation of membrane proteins faces significant challenges in accurately reproducing and predicting experimental observables such as ion conductance permeability due to its incapability precisely describing the electronic interactions heterogeneous systems. In this work, free energy profiles K+ Na+ permeating through gramicidin A channel are characterized by using AMOEBA polarizable force field with a total sampling time 1 μs. Our results indicated that...
In this work, we attempt to apply a coarse-grained (CG) model, which is based on anisotropic Gay–Berne and electric multipole (EMP) potentials, the modeling of nucleic acids. First, comparison has been made between CG atomistic models (AMBER point-charge model) in DNA RNA hairpin structures. The results have demonstrated good quality maintaining acid structures, reproducing dynamics backbone atoms acids, describing hydrogen-bonding interactions base pairs. Second, AMBER yield comparable...
Osteosarcoma is the most common malignant tumor in skeletal system with high mortality. Phytic acid (PA) a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop novel theranostics for magnetic resonance imaging (MRI) therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles (MnO2@PA NPs) osteosarcoma treatment. The MnO2 NPs oligomer was formed by modification uniformed size distribution negative...
Gay-Berne anisotropic potential has been widely used to evaluate the non-bonded interactions between coarse-grained particles being described as elliptical rigid bodies. In this paper, we are presenting a model for twenty kinds of amino acids and proteins, based on point electric multipole (EMP) potentials. We demonstrate that model, namely GBEMP is able reproduce many key features observed from experimental protein structures (Dunbrack Library) well atomistic force field simulations (using...
Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility low bioactivity of Lut restrict its clinical translation. Herein, we developed reactive oxygen species (ROS)-responsive nanoplatforms to improve Lut. Folic acid (FA) was employed decorate nanoparticles (NPs) enhance targeting ability. The size Lut-loaded ROS-responsive (Lut/Oxi-αCD NPs)...
Accelerated Molecular Dynamics (aMD) is a promising enhanced sampling method to explore the conformational space of biomolecules. However, large statistical noise in reweighting limits its accuracy recover original free energy profile. In this work, we propose an Integrated accelerated Molecule (IaMD) by integrating series aMD subterms with different acceleration parameters improve efficiency and maintain simultaneously. We use Alanine Dipeptide three fast-folded proteins (Chignolin,...