A5103005641- Nanoplatforms for cancer theranostics
- Cardiac Health and Mental Health
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Heart Rate Variability and Autonomic Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Atherosclerosis and Cardiovascular Diseases
- Pickering emulsions and particle stabilization
- Inflammasome and immune disorders
- Skin Protection and Aging
- Surfactants and Colloidal Systems
- Acne and Rosacea Treatments and Effects
- Acute Myocardial Infarction Research
- Ocular Oncology and Treatments
- Acupuncture Treatment Research Studies
- Fault Detection and Control Systems
- Inflammation biomarkers and pathways
- Bioactive natural compounds
- Burn Injury Management and Outcomes
- Nanopore and Nanochannel Transport Studies
- Ginseng Biological Effects and Applications
Tongji University
2023-2025
Shanghai Skin Disease Hospital
2023-2025
Third Xiangya Hospital
2023-2024
Central South University
2023-2024
Army Medical University
2016-2023
Anhui Medical University
2013-2023
Harbin Medical University
2017-2023
Second Affiliated Hospital of Harbin Medical University
2017-2023
Guangzhou University
2023
Wuhan University
2020
Atherosclerosis is a leading cause of vascular diseases worldwide. Whereas antioxidative therapy has been considered promising for the treatment atherosclerosis in view critical role reactive oxygen species (ROS) pathogenesis atherosclerosis, currently available antioxidants showed considerably limited clinical outcomes. Herein, we hypothesize that broad-spectrum ROS-scavenging nanoparticle can serve as an effective taking advantage its stress activity and targeting effects. As proof...
Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based applications are limited depth tissue penetration, inevitable requirement external irradiation, poor biocompatibility nanoparticles. To overcome these critical limitations, we synthesized a sensitive, specific, biodegradable luminescent nanoparticle that is self-assembled from an amphiphilic polymeric conjugate with donor...
Despite the great potential of numerous antioxidants for pharmacotherapy diseases associated with inflammation and oxidative stress, many challenges remain their clinical translation. Herein, a superoxidase dismutase/catalase-mimetic material based on Tempol phenylboronic acid pinacol ester simultaneously conjugated β-cyclodextrin (abbreviated as TPCD), which is capable eliminating broad spectrum reactive oxygen species (ROS), reported. TPCD can be easily synthesized by sequentially...
To develop reactive oxygen species (ROS)-responsive anti-inflammatory materials and establish their structure–property correlations, a series of H2O2-eliminating (OxbCDs) were designed synthesized by conjugating different phenylboronic acid pinacol ester (PBAP) groups onto biocompatible scaffold compound β-cyclodextrin via varied linker groups. Both the H2O2-triggered hydrolysis profiles capacities these dependent on chemical structure PBAP moieties. Together with elucidation mechanisms, we...
Abstract Inflammation is a common cause of many acute and chronic inflammatory diseases. A major limitation existing anti‐inflammatory therapeutics that they cannot simultaneously regulate pro‐inflammatory cytokine production, oxidative stress, recruitment neutrophils macrophages. To overcome this limitation, nanoparticles (NPs) with multiple pharmacological activities are synthesized, using chemically modified cyclic oligosaccharide. The manufacture type bioactive, saccharide material‐based...
The cGAS-STING pathway, as a vital innate immune signaling has attracted considerable attention in tumor immunotherapy research. However, STING agonists are generally incapable of targeting tumors, thus limiting their clinical applications. Here, photodynamic polymer (P1) is designed to electrostatically couple with 56MESS-a cationic platinum (II) agent-to form NPPDT -56MESS. accumulation -56MESS the tumors increases efficacy and decreases systemic toxicity drugs. Moreover, generates...
Personality traits are associated with major adverse coronary events (MACE) in patients artery disease (CAD). However, the link between personality and intravascular morphology CAD is poorly understood. This study investigated relationship traits, specifically Type A behavior pattern D personality, plaque vulnerability. After adjustment for demographic clinical factors, multivariable regression analysis showed no association optical coherence tomography indices. was independently lipid...
Liver injury can result in different hepatic diseases such as fatty liver, liver fibrosis, hepatitis, and failure, which are mainly responsible for global mortality morbidity. Early diagnosis is critical the treatment of diseases. Herein we report luminescence imaging neutrophil-mediated acute injury, including alcoholic (ALI) failure (ALF). To this purpose, a biodegradable luminescent material was developed by chemical functionalization cyclic oligosaccharide, be produced into nanoprobes...
Abstract In the treatment of uveal melanoma (UVM), histone deacetylase inhibitors (HDACi) have emerged as a promising epigenetic therapy. However, their clinical efficacy is hindered by suboptimal pharmacokinetics and strong self‐rescue tumor cells. To overcome these limitations, reactive oxygen species (ROS)‐responsive nanoparticles (NPs) are designed that encapsulate HDACi MS‐275 glutamine metabolism inhibitor V‐9302. Upon reaching microenvironment, NPs can disintegrate, thereby releasing...
Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions. This study aimed to assess the effectiveness safety of STBF-PDT treatment moderate-to-severe rosacea. In this prospective, randomised, evaluator-blind controlled study, patients rosacea were assigned receive up six sessions or 100 mg doxycycline daily eight weeks, followed by a 24-week...
Recent Multimodal Large Language Models (MLLMs) have achieved remarkable performance but face deployment challenges due to their quadratic computational complexity, growing Key-Value cache requirements, and reliance on separate vision encoders. We propose mmMamba, a framework for developing linear-complexity native multimodal state space models through progressive distillation from existing MLLMs using moderate academic resources. Our approach enables the direct conversion of trained...
Humans may be exposed to chlorine gas via accidental or intentional release, and effective countermeasures for the resulting lung injury are lacking. To develop a model in which therapeutic measures could evaluated, induced by inhalation two inbred mouse strains was examined. C57BL/6 FVB/N mice were 1.1 h varying doses of (197-289 ppm-h) evaluated indices at different times after exposure (6-48 h). Chlorine increases weight that more evident than mice. Both exhibited sloughing airway...
Abstract Background Type D personality and depression are the independent psychological risk factors for adverse outcomes in cardiovascular patients. The aim of this study was to examine combined effect on clinical patients suffering from acute myocardial infarction (AMI). Methods This prospective cohort included 3568 diagnosed with AMI between February 2017 September 2018. were assessed at baseline, while major cardiac event (MACE) rate (cardiac death, recurrent non-fatal infarction,...
Asthma is a serious global public health concern. Airway neutrophilic inflammation closely related to severe asthma, for which effective and safe therapies remain be developed. Here we report nanotherapies capable of simultaneously regulating multiple target cells relevant the pathogenesis asthma. A nanotherapy LaCD NP based on cyclic oligosaccharide-derived bioactive material was engineered. effectively accumulated in injured lungs asthmatic mice mainly distributed neutrophils, macrophages,...
Emulsions are widely used in numerous fields. Therefore, there has been increasing interest the development of new emulsification strategies toward emulsions with advanced functions. Herein we report formation diverse by host-guest interaction-mediated interfacial self-assembly under mild conditions. In this strategy, a hydrophilic diblock copolymer one block containing β-cyclodextrin (β-CD) can assemble at oil/water interface when its aqueous solution is mixed an oil phase benzyl alcohol...