A5042037525- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Electrochemical Analysis and Applications
- Ferroptosis and cancer prognosis
- Advanced Nanomaterials in Catalysis
- Insect and Pesticide Research
- Gut microbiota and health
- Electrochemical sensors and biosensors
- Advanced Photocatalysis Techniques
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Analytical Chemistry and Sensors
- Pesticide Residue Analysis and Safety
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Polymer Surface Interaction Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Nanocluster Synthesis and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protease and Inhibitor Mechanisms
- Kruppel-like factors research
Nankai University
2025
Yangtze University
2021-2025
University of Jinan
2021-2024
Qufu Normal University
2020-2024
China National Institute of Standardization
2024
Sun Yat-sen University
2020-2024
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
Army Medical University
2014-2023
Huazhong University of Science and Technology
2023
The incidence and prevalence of inflammatory bowel disease (IBD) increases steadily worldwide. There is an urgent need for effective safe IBD therapies. Accelerated resolution inflammation a new strategy the management diseases. For treatment, herein smart nanotherapy (i.e. oxidation-responsive nanoparticles containing proresolving annexin A1-mimetic peptide Ac2-26, defined as AON) developed, which can release packaged in response to highly expressed reactive oxygen species (ROS) at diseased...
Abstract The deficient catalytic activity of nanozymes and insufficient endogenous H 2 O in the tumor microenvironment (TME) are major obstacles for nanozyme‐mediated therapy. Since electron transfer is basic essence catalysis‐mediated redox reactions, we explored contributing factors enzymatic based on positive negative charges, which experimentally theoretically demonstrated to enhance peroxidase (POD)‐like a MoS nanozyme. Hence, an acidic microenvironment‐responsive ultrasound‐mediated...
Targeting of nanoparticles to distant diseased sites after oral delivery remains highly challenging due the existence many biological barriers in gastrointestinal tract. Here we report targeted diverse multiple disease models, via a "Trojan horse" strategy based on bioinspired yeast capsule (YC). Diverse charged nanoprobes including quantum dots (QDs), iron oxide (IONPs), and assembled organic fluorescent can be effectively loaded into YC through electrostatic force-driven spontaneous...
Despite the great potential of numerous antioxidants for pharmacotherapy diseases associated with inflammation and oxidative stress, many challenges remain their clinical translation. Herein, a superoxidase dismutase/catalase-mimetic material based on Tempol phenylboronic acid pinacol ester simultaneously conjugated β-cyclodextrin (abbreviated as TPCD), which is capable eliminating broad spectrum reactive oxygen species (ROS), reported. TPCD can be easily synthesized by sequentially...
Abstract MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases cellular process. Decreased miR-181a has been observed the patients with coronary artery disease, but its function mechanism atherogenesis is not clear. This study was designed to determine roles miR-181a-5p, well passenger strand, miR-181a-3p, vascular inflammation atherogenesis. We found that levels both miR-181a-5p miR-181a-3p decreased aorta plaque plasma...
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide. Vascular inflammation is closely related to pathogenesis a diverse group CVDs. Currently, it remains great challenge achieve site-specific delivery controlled release therapeutics at vascular inflammatory sites. Herein we hypothesize that active targeting nanoparticles (NPs) simultaneously responsive low pH high levels reactive oxygen species (ROS) can serve as an effective nanoplatform for...
Caffeic acid (3,4-dihydroxycinnamic acid, CA) has been reported to have anti-inflammatory activity in animal models. However, the mechanisms underlying effects of CA skin inflammation are only partially understood. The present study was designed investigate and on acute chronic mice effect keratinocytes vitro. results showed that topical treatment with inhibited 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced edema a dose-dependent manner, leading substantial reductions thickness tissue...
Abstract Inflammation is a common cause of many acute and chronic inflammatory diseases. A major limitation existing anti‐inflammatory therapeutics that they cannot simultaneously regulate pro‐inflammatory cytokine production, oxidative stress, recruitment neutrophils macrophages. To overcome this limitation, nanoparticles (NPs) with multiple pharmacological activities are synthesized, using chemically modified cyclic oligosaccharide. The manufacture type bioactive, saccharide material‐based...
Abstract Atherosclerosis remains the leading cause of a broad spectrum deadliest cardiovascular diseases. MicroRNA‐33 is new therapeutic target for atherosclerosis due to its diverse functions. However, it great challenge in clinical translation nucleic acid‐based microRNA‐targeting therapeutics. Considering lesional acidosis, herein cyclodextrin‐derived pH‐responsive and integrin‐targeting nanoparticles containing an antisense oligonucleotide against microRNA‐33 (anti‐miR33) are engineered...
Abstract Aims Our previous study demonstrated that Ca2+ influx through the Orai1 store-operated channel in macrophages contributes to foam cell formation and atherosclerosis via calcineurin–ASK1 pathway, not classical calcineurin–nuclear factor of activated T-cell (NFAT) pathway. Moreover, up-regulation NFATc3 inhibits formation, suggesting macrophage is a negative regulator atherogenesis. Hence, this investigated precise role Methods results Macrophage-specific knockout mice were generated...
Abstract Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of transplantation. Transmembrane member 16A (TMEM16A), component hepatocyte Ca 2+ -activated chloride channel, has been implicated in variety diseases. However, its role hepatic I/R remains unknown. Here, mice hepatocyte-specific TMEM16A knockout or overexpression were generated to examine the effect on injury. expression increased samples from patients and injury, which was correlated...
Photocatalytic reduction of CO2 using solar energy is an effective means to achieve carbon neutrality. However, the photocatalytic efficiency still requires improvements. In this study, polyvinylidene fluoride (PVDF) ferroelectric/piezoelectric nanofiber membranes are prepared by electrospinning. Cadmium sulfide (CdS) nanosheets assembled in situ on surface PVDF based coordination between F- and Cd2+ , then Ag nanoparticles deposited CdS. Because synergistic effect localized plasmon...
<p indent="0mm">Atherosclerosis (AS), the main contributor to acute cardiovascular events, such as myocardial infarction and ischemic stroke, is characterized by necrotic core formation plaque instability induced cell death. The mechanisms of death in AS have recently been identified elucidated. Ferroptosis, a novel iron-dependent form death, has proven participate atherosclerotic progression increasing endothelial reactive oxygen species (ROS) levels lipid peroxidation. Furthermore,...
Abstract Background Gut microbiota and metabolites have been shown to influence the development of inflammatory bowel disease (IBD). Exosomes derived from human umbilical cord mesenchymal stem cells (HucMSC-Exo) identified as a promising biological therapy for treatment IBD. Previous studies described that HucMSC-Exo could modulate gut microbiota. However, mechanism remains unclear. Here, we explored role in HucMSC-Exo-mediated amelioration experimental colitis. Methods Dextran sulfate...