A5012937567- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- Natural Compounds in Disease Treatment
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Chemical Synthesis and Analysis
- Bone Metabolism and Diseases
- Wound Healing and Treatments
- Histone Deacetylase Inhibitors Research
- Click Chemistry and Applications
- Cell Adhesion Molecules Research
- interferon and immune responses
- Autophagy in Disease and Therapy
- Bone health and treatments
- Cell death mechanisms and regulation
- Electrospun Nanofibers in Biomedical Applications
- Lung Cancer Treatments and Mutations
- Cell Image Analysis Techniques
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Sun Yat-sen University
2015-2024
Helmholtz Centre for Infection Research
2022
Technische Universität Braunschweig
2022
State Key Laboratory of Synthetic Chemistry
2022
University of Hong Kong
2022
Center for Excellence in Molecular Cell Science
2016-2020
Shanghai Institute of Materia Medica
2016-2020
Chinese Academy of Sciences
2016-2020
Space Engineering University
2020
Chronic diabetic wounds are a severe complication of diabetes, often leading to high treatment costs and amputation rates. Numerous studies have revealed that nitric oxide (NO) therapy is promising option because it favours wound revascularization. Here, base-paired injectable adhesive hydrogels (CAT) were prepared using adenine- thymine-modified chitosan (CSA CST). By further introducing S-nitrosoglutathione (GSNO) binary L-arginine (bArg), we obtained NO sustained-release hydrogel...
The principal problem arising from prostate cancer (PCa) is its propensity to metastasize bone. MicroRNAs (miRNAs) play a crucial role in many tumor metastases. importance of miRNAs bone metastasis PCa has not been elucidated date. We investigated whether the expression certain was associated with PCa. examined miRNA profiles 6 primary and 7 metastatic samples by microarray analysis. 5 significantly decreased compared PCa, including miRs-508-5p, -145, -143, -33a -100. further other 16 13...
An efficient one-pot chemoenzymatic glycoengineering technology introduced reactive functional groups (azido <italic>etc.</italic>) onto IgG Fc <italic>N</italic>-glycans for preparation of novel glycosite-specific ADCs as anticancer reagents.
Gefitinib is a first-line therapy in the EGFR-mutated nonsmall cell lung cancer (NSCLC). However, development of drug resistance almost unavoidable, thus leading to an unsustainable regimen. EGFRT790M mutation major cause responsible for molecular-targeting failure NSCLC. Although recently approved osimertinib effective EGFRT790M-positive NSCLC, osimertinib-resistant EGFR rapidly developed, too. In this study, we proposed tumor-associated macrophage (TAM) reprogramming strategy overcoming...
Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize bone. miR-141-3p is an extensively studied miRNA in cancers and downregulation of has been widely reported be involved the progression metastasis several human types. However, clinical significance biological roles bone PCa are still unclear. expression was examined 89 non-bone metastatic 52 tissues by real-time PCR. Statistical analysis performed investigate correlation between levels clinicopathological...
Reduced tissue levels of endothelial progenitor cells (EPCs) and functional impairment endothelium are frequently observed in patients with diabetes cardiovascular disease. The vascular is specifically sensitive to oxidative stress, this one the mechanisms that causes widespread dysfunction most diseases disorders. Hence attention has increasingly been paid enhance mobilization differentiation EPCs for therapeutic purposes. aim study was investigate whether Icariin, a natural bioactive...
A number of studies have reported that aberrant expression microRNAs (miRNAs) closely correlates with the bone metastasis prostate cancer (PCa). However, clinical significance and functional roles both strands a single miRNA in PCa remain undefined. Here, we miR-582-3p miR-582-5p were simultaneously reduced metastatic tissues compared non-bone tissues. Downexpression strongly positively correlated advanced clinicopathological characteristics shorter metastasis-free survival patients....
Drug-antibody ratio (DAR) of antibody-drug conjugates (ADCs) is important for their therapeutic efficacy and pharmacokinetics, therefore control on DAR in synthesis process a key ADC quality control. Although various analytical methods were reported, the real-time monitoring still challenge because time-consuming sample preparation usually needed during analysis. Antibody deglycosylation simplifies measurement, however long-time PNGaseF digestion hampers detection. Here, we report rapid...
Mounting evidence demonstrates uncontrolled endoplasmic reticulum (ER) stress responses can activate the inflammasome, which generally results in endothelial dysfunction, a major pathogenetic factor of chronic inflammatory diseases such as atherosclerosis. Salvianolic acid B (SalB), produced by Radix Salviae, exerts antioxidative and anti-inflammatory activities multiple cell types. However, SalB's effects on ER stress-related inflammasome dysfunction remain unknown. Here, we showed SalB...
With the increase of age, increased susceptibility to apoptosis and senescence may contribute proliferative functional impairment endothelial progenitor cells (EPCs). The aim this study was investigate whether salidroside (SAL) can induce angiogenic differentiation inhibit oxidative stress-induced in bone marrow-derived EPCs (BM-EPCs), if so, through what mechanism.BM-EPCs were isolated treated with different concentrations SAL for up 4 days. Cell proliferation, migration tube formation...
miR-218-5p is an extensively studied microRNA (miRNA) in prostate cancer (PCa). However, the clinical significance and biological role of bone metastasis PCa remain unclear.miR-218-5p expression was evaluated 38 metastatic 115 non-bone tissues serum samples. Clinical correlation with clinicopathological characteristics analyzed. The roles were investigated vitro by invasion migration assays. Bioinformatics analysis, real-time polymerase chain reaction, western blot, luciferase reporter assay...
The prime issue derived from prostate cancer (PCa) is its high prevalence to metastasize bone. MicroRNA-204-5p (miR-204-5p) has been reported be involved in the development and metastasis a variety of cancers. However, clinical significance biological functions miR-204-5p bone PCa are still not yet. In this study, we find that expression reduced tissues serum sample with compared without metastasis, which associated advanced clinicopathological characteristics poor metastasis-free survival...
Cell migration on rigid surfaces employs flat protrusions termed lamellipodia, which constitute the prime model system for branched actin filament networks that generate pushing forces membrane movement. Branched filaments are nucleated by Arp2/3 complex and play vital roles in various cell biological processes, such as organelle trafficking, phagocytosis autophagy. Here we utilize genome editing to explore functional connections between monomer-binding protein profilin (Pfn), nucleating...
Background/Aims: Prostate cancer (PCa) is one of the most common malignant cancers and a major leading cause deaths in men. Cancer stem-like cells are shown to be highly tumorigenic, pro-angiogenic can significantly contribute tumor new vessel formation bone marrow derived-EPCs (BM-EPCs) recruit angiogenic switch growth metastatic progression, suggesting importance targeting stem (CSCs) EPCs for novel therapies. Pristimerin, an active component isolated from Celastraceae Hippocrateaceae, has...
Cross-talk between Rho- and Arf-family guanosine triphosphatases (GTPases) plays an important role in linking the actin cytoskeleton to membrane protrusions, organelle morphology, vesicle trafficking. The central regulator, WAVE regulatory complex (WRC), integrates Rac1 (a Rho-family GTPase) Arf signaling promote Arp2/3-mediated polymerization many processes, but how WRC senses is unknown. Here, we have reconstituted a direct interaction WRC. This greatly enhanced by binding D site of Arf1...