A5045532830- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Eosinophilic Esophagitis
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Cancer Cells and Metastasis
- Retinal Diseases and Treatments
- Lymphatic System and Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Parasites and Host Interactions
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Corneal Surgery and Treatments
- Hormonal Regulation and Hypertension
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2021-2023
Cancer Research Center
2022
State Key Laboratory of Oncology in South China
2021
Shanxi University
2017
Shanxi University of Traditional Chinese Medicine
2017
University of Oklahoma Health Sciences Center
2013-2016
Guangzhou Medical University
2013-2016
Department of Education of Guangdong Province
2013-2016
University of Maryland, Baltimore
2010-2015
Type 2 immunity is essential for host protection against nematode infection but detrimental in allergic inflammation or asthma. There a major research focus on the effector molecules and specific cell types involved initiation of type immunity. Recent work has implicated an important role epithelial-derived cytokines, IL-25 IL-33, acting innate immune cells that are believed to be initial sources cytokines IL-4/IL-5/IL-13. The identities mediate effects IL-25/IL-33, however, remain fully...
Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many cells, especially macrophages. Immune molecules, including some cytokines, have close relationship metabolism. Interleukin (IL)-25 is member IL-17 cytokine family that can regulate macrophages alleviate dysfunction; however, its role mechanisms in lipid metabolism remain to be extensively clarified. Human serum liver biopsy specimens, high-fat diet-induced...
Gut microbiota and the tumor microenvironment are thought to be critical factors that modulate processes of liver diseases, including hepatocellular carcinoma (HCC). Interleukin-25 (IL-25) promotes type 2 immunity via alternative activation macrophages, is closely associated with inflammation-related even malignancies. However, it not clear which role IL-25 plays in development HCC, whether gut involved. was detected by ELISA, Western blotting (WB), immunohistochemistry. Chemokines were...
IL-25 (IL-17E) is a member of the IL-17 cytokine family. IL-25-deficient mice exhibit impaired Th2 immunity against nematode infection, implicating as key component in mucosal immunity. The sources and mechanisms responsible for induction by gastrointestinal tract remain poorly understood. There also little information on regulation during inflammation or its role gut function. In current study, we investigated Nippostrongylus brasiliensis infection contribution to infection-induced...
Obesity is associated with a chronic low-grade inflammation characterized by increased levels of proinflammatory cytokines that are implicated in disrupted metabolic homeostasis. Parasitic nematode infection induces polarized Th2 cytokine response and has been explored to treat autoimmune diseases. We investigated the effects against obesity dysfunction. Infection RIP2-Opa1KO mice or C57BL/6 fed high-fat diet (HFD) Nippostrongylus brasiliensis decreased weight gain was improved glucose...
Epithelial–mesenchymal transition (EMT) is a crucial programme in cancer metastasis. Epidermal growth factor (EGF) key inducer of EMT, and Ezrin has an important role this process. However, how activated whether it mediates EGF-induced EMT tongue squamous cell carcinomas (TSCCs) through activating NF-κB remains obscure. We used two TSCC lines as model to study invasion vitro, nude mice xenografts evaluate metastasis cells. Finally, we evaluated the level pEzrin Tyr353, nuclear p65 markers...
Significance CRC patients with KRAS mutations are confronted limited targeted therapeutic options. In this study, we have shown that the median survival time for -mutation mCRC diabetes on metformin is 37.8 mo longer than those treated other hypoglycemic drugs in combination standard systemic therapy. Metformin preferentially accumulated cells both primary cell cultures and patient-derived xenografts. The promising activity of has a negative correlation MATE1 expression, which proven to...
The accumulation of M1-polarized macrophages and excessive inflammation are important in the pathogenesis diabetic foot ulcer (DFU). However, underlying mechanism DFU crucial regulators less well known. Our previous study reported that kallikrein-binding protein (KBP), an angiogenesis inhibitor, was significantly upregulated patients compared to its levels controls. effects KBP on monocyte chemotaxis macrophage M1 polarization were elucidated this study. Plasma counts assessed by ELISA flow...
Distant metastasis is, unfortunately, the leading cause of death in colorectal cancer (CRC). Approximately 50% CRC patients develop liver metastases, while 10-30% pulmonary metastases. The occurrence is considered to be almost exclusively driven by stem cells (CSCs) formation. However, key molecules that confer transformation CRC, and subsequent metastasis, remain unclear. Far upstream element-binding protein 1 (FUBP1), a transcriptional regulator c-Myc, was screened CSCs mass spectrometry...
Abstract Background Gut microbiota and microbe-derived metabolites are involved in the development of HCC. Bile acids (BAs) most important gut microbiota-modulated endogenous signaling molecules. Methods We tested serum bile acid levels microbiome compositions patients with HCC, chemical-induced HCC mouse models (DEN-HCC mice) orthotopic implanted liver tumor vancomycin treatment (vancomycin-treated mice). Then, we screened an kind HCC-related BAs, verified its effect on growth vivo vitro....
Without therapeutic intervention, corneal neovascularization rapidly compromises visual acuity, and is a leading cause of blindness. Artesunate was reported to inhibit angiogenesis in tumors, although, the effects artesunate on nontumor have not been investigated. This study designed investigate effect delineate its underlying mechanism action.Rats with alkali-burned corneas were treated for 11 days. Corneal evaluated by measuring length area vasculature rats. Apoptotic cells stained...
Pigment epithelium-derived factor (PEDF), an angiogenesis inhibitor with multiple other functions, balances in the eye and blocks tumor progression. Retinoblastoma, angiogenesis-dependent tumor, is most common ocular cancer children without effective treatment. It has been reported that PEDF can induce neuronal differentiation of retinoblastoma cells; however, its anti-angiogenic potential for inhibition growth vivo not elucidated. The present study was designed to investigate effect on...
SerpinB2, a member of the serine protease inhibitor family, is expressed by macrophages and significantly upregulated inflammation. Recent studies implicated role for SerpinB2 in control Th1 Th2 immune responses, but mechanisms these effects are unknown. In this study, we used mice deficient (SerpinB2(-/-)) to investigate its host response enteric nematode, Heligmosomoides bakeri. Nematode infection induced STAT6-dependent increase intestinal expression. The H. bakeri-induced upregulation...
IL-33 is a recently identified cytokine member of the IL-1 family. The biological activities are associated with promotion Th2 and inhibition Th1/Th17 immune responses. Exogenous induces typical “type 2” response in gastrointestinal tract, yet underlying mechanisms remain to be fully elucidated. In addition, role regulation function not known. present study investigated IL-33-dependent intestinal immunity mice. induced polarized type 2 intestine that was entirely MyD88 dependent but STAT6...
Gastric cancer is one of the most malignant tumor types, and its metastasis a notable cause mortality. Among methods metastasis, lymphatic predominant in gastric cancer. A previous study reported that plasma oxidized low‑density lipoprotein (oxLDL) risk factor associated with development tumors patients abnormal lipid metabolism, but influence oxLDL remains unclear. In present study, concentration from was detected an ELISA kit, vessel density tissues determined by D2‑40 staining. The...
Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies MYCN are considered most important marker for prediction tumour relapse and progression in NB, but they were only detected 20-30% NB patients, indicating there might be other oncogenes development NB. The far upstream element binding protein 1 (FUBP1) was first identified as a transcriptional regulator proto-oncogene MYC. However, expression role FUBP1 have not...
Beige fat dissipates energy and functions as a defense against cold obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose tissue after exposure β3-adrenoceptor agonist stimulation. IL-25 induced beige formation white (WAT) by releasing IL-4 IL-13 promoting alternative activation of macrophages regulate innervation up-regulate tyrosine hydroxylase (TH) up-regulation to...
Nasopharyngeal carcinoma (NPC), which has the highest incidence in South China, is mainly treated by radiotherapy. However, survival rate remains low. Angiogenesis closely correlated with progress of NPC. Thus, combination anti‐angiogenesis radiation an attractive strategy for NPC treatment. A heterogenic xenografted human nude mice model was established to investigate effect pigment epithelium‐derived factor (PEDF), a potent anti‐angiogenic factor, and combined PEDF radiotherapy on...