A5048913550- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Retinal Diseases and Treatments
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Tryptophan and brain disorders
- Cancer-related gene regulation
- Gut microbiota and health
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Connective tissue disorders research
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Advanced Glycation End Products research
- Retinal and Macular Surgery
- Traditional Chinese Medicine Analysis
- Pharmacological Receptor Mechanisms and Effects
- Lipid metabolism and disorders
Soochow University
2022-2025
Shanghai Changzheng Hospital
2021-2024
Southern Medical University
2021-2024
Nanfang Hospital
2021-2024
Photonic Science (United Kingdom)
2024
Weatherford College
2024
Kunming Children's Hospital
2024
Kunming Medical University
2024
Sichuan University
2021-2023
West China Hospital of Sichuan University
2021-2023
Gut microbiota and the tumor microenvironment are thought to be critical factors that modulate processes of liver diseases, including hepatocellular carcinoma (HCC). Interleukin-25 (IL-25) promotes type 2 immunity via alternative activation macrophages, is closely associated with inflammation-related even malignancies. However, it not clear which role IL-25 plays in development HCC, whether gut involved. was detected by ELISA, Western blotting (WB), immunohistochemistry. Chemokines were...
To investigate the effects of recombinant human type XVII collagen (RHCXVII) on proliferation and adhesion primary keratinocytes (HPKCs) to observe its clinical efficacy safety in bullous pemphigoid (BP). The RHCXVII was produced by genetic recombination technology characterized Fourier transform infrared (FTIR) spectroscopy. HPKCs were obtained from foreskin seeded onto culture plates coated with at concentrations 10, 50 100μg/ml. relative assessed Cell Counting Kit-8 (CCK-8) assays,...
A major hallmark of pancreatic ductal adenocarcinoma (PDAC) is extensive local tumor invasion and early systemic dissemination. DJ-1 has been shown to prevent cell death via the Akt pathway, thereby playing an important role in cancer progression Parkinson's disease development. Here, we investigated metastasis showed that upregulated 68.5% specimens, correlated with stage predictive short overall survival. Knockdown expression two PDAC lines reduced migration potential vitro inhibited vivo...
Arsenic trioxide (ATO) is commonly used in the treatment of acute promyelocytic leukemia (APL), but does not benefit patients with solid tumors. When combined other agents or radiation, ATO showed benefits manageable toxicity. Previously, we reported that metformin amplified inhibitory effect on intrahepatic cholangiocarcinoma (ICC) cells more significantly than agents. Here, investigated chemotherapeutic sensitization ATO-based ICC vitro and vivo explored underlying mechanisms. cell lines...
Abstract Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). DN has many pathological changes, but tubular injury considered to be a crucial feature and plays key role in progression DN. Accumulating studies have confirmed that Luteolin (3,4,5,7-tetrahydroxyflavone, Lut) possesses anti-inflammatory antioxidant activities, which may play kidney protection Objectives This paper described effects Lut on appropriated kidneys db/db mice searched possible...
Hepatocellular carcinoma (HCC), a primary liver cancer, is closely associated with the gut microbiota. However, role of fungi in development HCC remains unclear. The aim this study was to explore influence intestinal Candida albicans on HCC. Here, We found that patients showed significantly decreased diversity mycobiome and increased abundance C. albicans, compared cirrhosis. gavage WT models tumor size weight influenced plasma metabolome, which indicated by alterations 117 metabolites, such...
Arsenic trioxide (ATO) is a well-accepted chemotherapy agent in managing promyelocytic leukemia. ATO often causes severe health hazards such as hepatotoxicity, dermatosis, neurotoxicity, nephrotoxicity and cardiotoxicity. The production of reactive oxygen species, (ROS) play significant role ATO-induced hepatotoxicity. oral hypoglycemic drug, metformin, considered to be potential novel for chemoprevention the treatment cancer. Moreover, metformin has also been shown have hepatoprotective...
C-X-C motif chemokine ligand 2 (CXCL2) is a small secreted protein that exhibits structure similar to the proangiogenic subgroup of CXC family. Recently, accumulating evidence suggests chemokines play pivotal role in cancer progression and carcinogenesis. We examined expression levels 7 types ELR＋ CXCLs messenger RNA (mRNA) 264 clinical samples. found CXCL2 was stably down-regulated 94% hepatocellular carcinoma (HCC) specimens compared with paired adjacent normal liver tissues some HCC cell...
Hypercoagulation and neutrophilia are described in several cancers, however, whether they involved lung carcinogenesis is currently unknown. Emodin the main bioactive component from Rheum palmatum has many medicinal values, such as anti-inflammation anticancer. This study to investigate contributions of neutrophils effects emodin on hypercoagulation carcinogenesis. The neutrophil phenotypes were assessed by cell proliferation, morphological changes, phagocytosis autophagy vitro....
Multiple myeloma (MM) is a clinically and biologically heterogeneous plasma-cell malignancy. Despite extensive research, disease heterogeneity relapse remain big challenge in MM therapeutics. We tried to dissect this identify novel biomarkers for patient stratification treatment outcome prediction by applying single-cell technology.
Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by dysfunctional inflammatory response. However, no effective therapeutic options have been reported so far. Microglia polarization has proposed to exert an essential role in modulating response after SAH. Sestrin2 stress protein. Growing evidence that sestrin2 could inhibit M1 microglia and promote M2 polarization. The current study investigated the effects of on phenotype switching subsequent brain injury sought...
6-Gingerol (6-G) is the main bioactive component in Ginger (Zingiber officinale Roscoe). The aim of this study was to explore contribution macrophage polarization 6-G-associated anti-cancer effects. In a urethane-induced lung carcinogenic model, carcinogenesis positively correlated with (F4/80+) infiltration interstitial control group. Furthermore, higher numbers arginase+/F4/80+ M2 cells than iNOS+/F4/80+ M1 were observed macrophages. Moreover, depletion by liposome-encapsulated clodronate...
This study explores the contributions of neutrophils to chemotherapeutic resistance and berberine-regulated cancer cell sensitivity doxorubicin (DOX). In vitro experiments, continuous DOX treatment led shift HL-60 cells N2 thus induced resistance. The combination with 2 µM berberine resulted in differentiation toward N1 therefore stimulated immune clearance. Berberine increased reactive oxygen species (ROS) decreased autophagy apoptosis HL-60-N2 morphological changes, but had no effect on...
Studies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.The study investigated whether azithromycin (AZT) could promote high-fat diet (HFD)-induced Moreover, effect of citrus reticulata pericarpium (CRP) extract on via regulation microbiome exposed antibodies early life were...
A characteristic toxicity of niraparib is a decrease in blood platelets (PLT), with an incidence ~ 34% for grades 3 - 4 conditions. However, exceedingly severe cases have been reported infrequently. This paper describes three patients acute and refractory PLT deficiency due to administration. The symptom characteristics, treatment course, outcomes also analyzed, the potential involvement immune-related factors considered. Therefore, it recommended comprehensively assess bone marrow...
Abstract Background Stomach adenocarcinoma (STAD) is the fifth most prevalent cancer in world and ranks third among cancer-related deaths worldwide. The tumour microenvironment (TME) plays an important role tumorigenesis, development, metastasis. Hence, we calculated immune stromal scores to find potential prognosis-related genes STAD using bioinformatics analysis. Methods ESTIMATE algorithm was used calculate immune/stromal of samples. Functional enrichment analysis, protein–protein...
Chronic obstructive pulmonary disease (COPD) is an important risk factor for developing lung cancer. Aged citrus peel (chenpi) has been used as a dietary supplement respiratory diseases in China.To explore the mechanism and candidate compounds of chenpi preventing COPD its progression to cancer.The active components potential targets were retrieved from Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Disease-associated cancer collected Gene Cards TTD The component-target...
Hepatic hemangiomas are the most common benign liver tumors, and management of giant hepatic hemangioma (GHH) is still in controversial. The aim this meta-analysis was to compare postoperative outcomes enucleation versus anatomic resection for GHH.PubMed, Embase, Web Science, Cochrane Library were searched from January 1988 December 2015 identify studies comparing GHH. Finally, we performed using Review Manager 5.3 software, results presented as risk ratio (RR) or mean difference (MD) with...