A5080867840- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Mechanisms and Therapy
- Gallbladder and Bile Duct Disorders
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Neurotoxicity Research
- TGF-β signaling in diseases
- Endoplasmic Reticulum Stress and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Gut microbiota and health
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Heat shock proteins research
- Colorectal Cancer Treatments and Studies
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Medical University of South Carolina
2013-2017
MUSC Hollings Cancer Center
2013-2017
Key Laboratory of Guangdong Province
2016
Memorial Sloan Kettering Cancer Center
2013
The University of Texas MD Anderson Cancer Center
2013
Levine Cancer Institute
2013
Second Military Medical University
2009
Eastern Hepatobiliary Surgery Hospital
2009
Drug-induced liver injury (DILI) is a common adverse event, which compromises the safety of numerous drugs, poses significant risk to patient health, and enhances healthcare expenditures. Many articles have been recently published on DILI related research, though no relevant scientometric study has yet. This was aimed at comprehensively analyzing knowledge base emerging topics DILI.The reviews DILI, from 2010 2019 in Web Science Core Collection (WoSCC), were retrieved March 15, 2020, using...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and many patients are diagnosed with advanced disease. The treatment liver cancer has made significant strides in recent years, owing to practice immunotherapy drugs. Numerous studies have been published on for HCC; however, no relevant bibliometric study published. This aims gain a better understanding current situation identify potential new research directions by conducting analysis HCC.We searched Web Science Core...
Tumor cells co-express vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) that interact each other to support a self-sustainable cell growth. So far, this autocrine loop is not reported in human intrahepatic cholangiocarcinoma (ICC). Apatinib highly selective VEGFR2 inhibitor, but its effects on ICC have been investigated. In study, we phosphorylated were expressed at significantly high level patient tissues (P<0.05). vitro, treating lines RBE SSP25 with recombinant...
The occurrence and development of hepatocellular carcinoma (HCC) depends largely on such non-tumor factors as inflammatory condition, immune state, viral infection liver fibrosis. Various inflammation-based prognostic scores have been associated with survival in patients HCC, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR) nutritional index (PNI). aspartate aminotransferase/platelet count (APRI) is thought to be a biomarker fibrosis cirrhosis. This study aims evaluate...
Gut microbiota and the tumor microenvironment are thought to be critical factors that modulate processes of liver diseases, including hepatocellular carcinoma (HCC). Interleukin-25 (IL-25) promotes type 2 immunity via alternative activation macrophages, is closely associated with inflammation-related even malignancies. However, it not clear which role IL-25 plays in development HCC, whether gut involved. was detected by ELISA, Western blotting (WB), immunohistochemistry. Chemokines were...
Pancreatic fistula (PF) remains the most challenging complication after pancreaticoduodenectomy (PD). The purpose of this study was to identify risk factors PF and delineate its impact on patient outcomes.We retrospectively reviewed clinical data 532 patients who underwent PD divided them into group no group. Risk outcomes following were examined.PF found in 65 (12.2%) cases, whom 11 classified ISGPF grade A, 42 B, 12 C. Clinically serious postoperative complications versus mortality,...
Abstract Purpose: gp96 (grp94) is a key downstream chaperone in the endoplasmic reticulum (ER) to mediate unfolded protein response (UPR) and pathogenesis of multiple myeloma closely linked dysregulated UPR. In this study, we aimed determine roles initiation progression vivo vitro. Experimental Design: We generated mouse model with overexpression XBP1s conditional deletion B-cell compartment simultaneously identify development vivo. Using short hairpin RNA (shRNA) system, silenced human...
Increased cellular protein production places stress on the endoplasmic reticulum (ER), because many of nascent proteins pass through ER for folding and trafficking. Accumulation misfolded in triggers activation three well-known pathways including IRE1, ATF6, PERK. The activity each sensor modulates overall strategy managing quality control as needs change due to growth, differentiation, infection, transformation, host other possible physiological states. Here we review role multiple myeloma...
Abstract Background Gut microbiota and microbe-derived metabolites are involved in the development of HCC. Bile acids (BAs) most important gut microbiota-modulated endogenous signaling molecules. Methods We tested serum bile acid levels microbiome compositions patients with HCC, chemical-induced HCC mouse models (DEN-HCC mice) orthotopic implanted liver tumor vancomycin treatment (vancomycin-treated mice). Then, we screened an kind HCC-related BAs, verified its effect on growth vivo vitro....
Biliary stricture is the most common complication after liver transplantation, accounting for ~40% of all biliary complications [1] [2]. These remain a major cause morbidity and, in severe cases, mortality. Endoscopic treatment first-line benign [3]. The success rate endoscopic anastomotic 58%–76% patients with living-donor transplantation [4] [5]. Here, we show novel approach to managing following orthotopic failure retrograde cholangiopancreatography (ERCP) technique, even direct cholangioscopy.
Cholelithiasis is a condition characterized by the formation of stones in gallbladder and/or bile ducts. Proficient use duodenoscopy, laparoscopy, and choledochoscopy techniques plays pivotal role managing cholelithiasis. To enhance young doctors' proficiency multiendoscope technology application, training model for choledochoscopy, laparoscopy was established using live pig model. Initially, duodenoscope used to access duodenum through passage mouth, esophagus, stomach observe duodenal...
This study aimed to compare the outcomes of liver resection for unilateral and bilateral intrahepatic stones.Hepatectomy is effective in treating stones accompanied by biliary stricture or segmental atrophy. The between may be varied because different complexity these 2 subtypes disease.From January 1992 December 2008, 718 consecutive patients with underwent elective hepatectomy our center were reviewed. (n = 461) 257) compared. consistency extent (ELR) stone-affected segments (SAS) was...
Tumor suppression of Transforming Growth Factor (TGF-β) signaling pathway requires an adaptor protein, Embryonic Liver Fodrin (ELF). Disruption ELF expression resulted in miscolocalization Smad3 and Smad4, then disruption TGF-β signaling. However, the prognostic significance for hepatocellular carcinoma (HCC) hasn't been clarified. This study aimed to investigate whether measuring both TGF-β1 provides a more powerful predictor HCC prognosis than either marker alone.TGF-β1 protein were...
Serum enzymes, including lactate dehydrogenase (LDH) and alkaline phosphatase (ALP), have recently been reported to play important roles in tumor growth. Increases LDH ALP confirmed predict poor prognosis patients with various cancers. However, their prognostic value pancreatic cancer has not well studied. Therefore, we reviewed the preoperative data on 185 ductal adenocarcinoma (PDAC) who underwent surgery between July 2005 December 2010 explore of these markers. The cutoff points were...
Peripheral blood monocyte count is an easily assessable parameter of systemic inflammatory response. The aim this study was to determine whether prognostic in hepatocellular carcinoma (HCC) following hepatic resection. We retrospectively reviewed 351 patients with HCC treated resection from 2006 2009. Preoperative absolute peripheral count, demographics, and clinical pathological data were analyzed. On univariate multivariate analysis, elevated counts (≥545/mm3), tumor size ≥5 cm,...
// Fei Ji 1,2,3,* , Shunjun Fu Zhiyong Guo 1,2,3* Hui Pang 4 Dubo Chen 5 Xiaoping Wang 1,2,3 Weiqiang Ju Dongping Xiaoshun He Yunpeng Hua 6 and Baogang Peng 1 Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China 2 Guangdong Provincial Key Laboratory of Donation Immunology, 3 International Cooperation Base Science Technology (Organ Transplantation), Department Medical Records, Medicine, Liver Surgery, * These authors have contributed equally...
Posthepatectomy liver failure is one of the main causes death in patients after hepatectomy. This study intends to establish a prediction model predict risk posthepatectomy and provide scientific basis for further reducing incidence failure.This was retrospective analysis 1,172 with hepatocellular carcinoma undergoing partial Using univariate multivariate logistic regression analyses stepwise regression, established based on independent factors validated by bootstrapping 100 resamples,...
Background . Although expression of miR-200s is aberrant in liver fibrosis, its role fibrogenesis still remains unknown. Here, we investigated the miR-200c activation human hepatic stellate cells (HSCs) and induction fibrosis. Methods We engineered HSCs (LX2 cell line) to stably express (LX2-200c) or empty vector control (LX2-nc). Results upregulated α -smooth muscle actin (SMA) vimentin, enhanced growth migration, increased collagen type I (a main component ECM) gene secretion epidermal...