A5004737683- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- MicroRNA in disease regulation
- Anesthesia and Sedative Agents
- Advanced Optical Imaging Technologies
- Gut microbiota and health
- Cardiac Arrest and Resuscitation
- Digital Holography and Microscopy
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Circular RNAs in diseases
- Organ Transplantation Techniques and Outcomes
- Enhanced Recovery After Surgery
- Airway Management and Intubation Techniques
- Extracellular vesicles in disease
- Advanced Vision and Imaging
- Biochemical effects in animals
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
China Electronics Technology Group Corporation
2024-2025
Second Xiangya Hospital of Central South University
2025
Central South University
2023-2025
Outcomes Research Consortium
2024-2025
Key Laboratory of Guangdong Province
2024-2025
Ministry of Education of the People's Republic of China
2025
Northwest University
2025
Fudan University
2023-2024
Ferroptosis, a new type of cell death has been found to aggravate intestinal ischemia/reperfusion (I/R) injury. However, little is known about the changes gut microbiota and metabolites in I/R role on ferroptosis-induced This study aimed establish mouse model ileum organoid hypoxia/reoxygenation (H/R) explore during protective ability capsiate (CAT) against ferroptosis-dependent Intestinal induced disturbance significant metabolites. We that CAT metabolite levels preoperative stool patients...
Learning-based computer-generated holography (CGH) provides a rapid hologram generation approach for holographic displays. Supervised training requires large-scale dataset with target images and corresponding holograms. We propose an autoencoder-based neural network (holoencoder) phase-only generation. Physical diffraction propagation was incorporated into the autoencoder’s decoding part. The holoencoder can automatically learn latent encodings of holograms in unsupervised manner. proposed...
Intestinal ischemia/reperfusion (I/R) injury has high morbidity and mortality rates. Gut microbiota is a potential key factor affecting intestinal I/R injury. Populations exhibit different sensitivities to injury; however, whether this interpopulation difference related variation in gut unclear. Here, elucidate the interaction between microbiome injury, we performed 16S DNA sequencing on preoperative feces of C57BL/6 mice fecal transplantation (FMT) experiments germ-free mice. The transwell...
Deep learning offers a novel opportunity to achieve both high-quality and high-speed computer-generated holography (CGH). Current data-driven deep algorithms face the challenge that labeled training datasets limit performance generalization. The model-driven introduces diffraction model into neural network. It eliminates need for dataset has been extensively applied hologram generation. However, existing problem of insufficient constraints. In this study, we propose network capable...
Objective The pathogenesis of sepsis is complex, and the sepsis-induced systemic proinflammatory phase one key drivers organ failure consequent mortality. Akkermansia muciniphila (AKK) recognised as a functional probiotic strain that exerts beneficial effects on progression many diseases; however, whether AKK participates in still unclear. Here, we evaluated potential contribution to lethal development. Design Relative abundance gut microbial septic patients was evaluated. Cecal ligation...
Intestinal ischemia-reperfusion (I/R) injury is a devastating complication in the perioperative period. Dexmedetomidine commonly applied The authors aimed to determine effects of different doses dexmedetomidine (given before or after intestinal ischemia) on I/R and explore underlying mechanisms.Intestinal was produced rat by clamping superior mesenteric artery for 1 h followed 2 reperfusion. Intravenous infusion performed at 2.5, 5, 10 μg · kg(-1) h(-1) ischemic insult. In addition,...
Remote ischemic preconditioning (RIPC) may confer the cytoprotection in critical organs. The authors hypothesized that limb RIPC would reduce intestinal and pulmonary injury patients undergoing open infrarenal abdominal aortic aneurysm repair.In this single-center, prospective, double-blinded, randomized, parallel-controlled trial, 62 elective repair were randomly assigned a 1:1 ratio by computerized block randomization to receive or conventional (control). Three cycles of 5-min...
Introduction Acute lung injury (ALI) is a major cause of morbidity and mortality after intestinal ischaemia/reperfusion (I/R). The gut microbiota its metabolic byproducts act as important modulators the gut–lung axis. This study aimed to define role succinate, key metabolite, in I/R-induced ALI progression. Methods Gut mice subjected I/R were analysed using 16S rRNA gene sequencing. Succinate level alterations measured germ-free or conventional treated with antibiotics. Succinate-induced...
Myocardial ischemia/reperfusion (I/R) injury is still a lack of effective therapeutic drugs, and its molecular mechanism urgently needed.Studies have shown that the intestinal flora plays an important regulatory role in cardiovascular injury, but specific has not been fully elucidated.In this study, we found increase Ang II plasma was accompanied by levels myocardial during reperfusion patients with cardiopulmonary bypass.Furthermore, treatment enhanced mice I/R which reversed caveolin-1...
Abstract Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on immune function sepsis, an expert consensus focusing monitoring treatment sepsis-induced was developed. Literature related to sepsis were retrieved from PubMed, Web Science, Chinese National Knowledge Infrastructure design items opinions collected through online questionnaire. Then, Delphi method used form opinions, RAND...
Abstract Background Lactobacillus has been demonstrated to serve a protective role in intestinal injury. However, the relationship between murinus ( L. )-derived tryptophan metabolites and ischemia/reperfusion (I/R) injury yet be investigated. This study aimed evaluate of -derived I/R underlying molecular mechanism. Methods Liquid chromatograph mass spectrometry analysis was used measure fecal content mice undergoing patients cardiopulmonary bypass (CPB) surgery. Immunofluorescence,...
Background Recent studies had provided evidence that the gut microbiota is associated with sepsis. However, potential causal relationship remained unclear. Methods The present study aimed to explore effects between and sepsis by performing Mendelian randomization (MR) analysis utilizing publicly accessible genome-wide association (GWAS) summary-level data. Gut GWAS ( N = 18,340) were obtained from MiBioGen GWAS-summary-level data for gained UK Biobank (sepsis, 10,154 cases; 452,764...
Intestinal organoid transplantation is a promising therapy for the treatment of mucosal injury. However, how transplanted organoids regulate immune microenvironment recipient mice and their role in treating intestinal ischemia-reperfusion (I/R) injury remains unclear. Here, we establish method transplanting into I/R mice. We find that improve mouse survival, promote self-renewal stem cells after I/R, depending on enhanced ability macrophages polarized to an anti-inflammatory M2 phenotype....
There are significant differences in the susceptibility of populations to intestinal ischemia/reperfusion (I/R), but underlying mechanisms remain elusive. Here, we show that mice exhibit I/R-induced enterogenic sepsis. Notably, milnacipran (MC) content enterogenic-sepsis-tolerant is significantly higher. We also reveal pre-operative fecal MC cardiopulmonary bypass patients, including those with I/R injury, associated post-operative gastrointestinal injury. attenuates mouse injury wild-type...
Cysteine S-sulfinylation is an important oxidative post-translational modification on proteins that regulates a variety of cell and protein functions. Aberrant contributes to range human pathologies, such as cancer cardiovascular disease. However, efforts elucidate the roles in physiology disease have been hampered due lack methodology for selective direct monitoring this living cells. In work, we developed fluorogenic probe PAK sulfinic acids by using 1,2-allenic ketone recognition moiety....
Remote ischemic preconditioning (RIPC) may confer the protection in critical organs. The authors hypothesized that limb RIPC would reduce lung injury patients undergoing pulmonary resection.In a randomized, prospective, parallel, controlled trial, 216 elective thoracic resection under one-lung ventilation with propofol-remifentanil anesthesia were randomized 1:1 to receive either or conventional (control). Three cycles of 5-min ischemia/5-min reperfusion induced by blood pressure cuff served...
Cell death is an important biological process that believed to have a central role in intestinal ischaemia/reperfusion (I/R) injury. While the apoptosis inhibition pivotal preventing I/R, how necrotic cell regulated remains unknown. Necroptosis represents newly discovered form of programmed combines features both and necrosis, it has been implicated development range inflammatory diseases. Here, we show receptor-interacting protein 1/3 (RIP1/3) kinase mixed lineage domain-like recruitment...
Sepsis is associated with a high risk of death, and the crosstalk between gut microbiota sepsis gradually revealed. Indole 3-propionic acid (IPA) microbiota-derived metabolite that exerts immune regulation organ protective effects. However, role IPA in not clear. In this study, sepsis-related survival, clinical scores, bacterial burden, injury was assessed murine model cecal ligation puncture-induced polymicrobial sepsis. Aryl hydrocarbon receptor (AhR) highly specific inhibitor (CH223191)...