A5021275241- Immune Response and Inflammation
- Immune cells in cancer
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- NF-κB Signaling Pathways
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Immunotherapy and Immune Responses
- Eicosanoids and Hypertension Pharmacology
- Tryptophan and brain disorders
- X-ray Diffraction in Crystallography
- Antimicrobial Peptides and Activities
- Quinazolinone synthesis and applications
- Crystallization and Solubility Studies
- Gut microbiota and health
- Mesenchymal stem cell research
- Structural Load-Bearing Analysis
- Drug-Induced Hepatotoxicity and Protection
- Structural Behavior of Reinforced Concrete
- MicroRNA in disease regulation
- Inflammation biomarkers and pathways
- Stress Responses and Cortisol
- IL-33, ST2, and ILC Pathways
- Synthesis and Biological Evaluation
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
Hebei University
2024-2025
Jiangmen Central Hospital
2025
Daping Hospital
2015-2024
Army Medical University
2015-2024
Hainan Medical University
2021-2024
Army Medical College
2021
Zunyi Medical University
2019
Yahoo (United Kingdom)
2019
First Affiliated Hospital of Chinese PLA General Hospital
1997
117th Hospital of People's Liberation Army
1997
The aryl hydrocarbon receptor (AhR) is an important immune regulator with a role in inflammatory response. However, the of AhR IL-10 production by macrophages currently unknown. In this study, we investigated LPS-induced expression from AhR-KO mice and AhR-overexpressing RAW264.7 cells. was highly expressed after LPS stimulation through NF-κB pathway. Loss resulted reduced macrophages. Moreover, elevated Maximal dependent on non-genomic pathway closely related to Src STAT3. Furthermore,...
Stromal cell-derived factor-1 (SDF-1) is a potent chemokine for bone marrow-derived stromal stem cells (BMSCs) that express CXCR4, the receptor SDF-1. SDF-1 considered to play an important role in trafficking of BMSCs. We investigated contribution recruitment BMSCs wound area and its promotion repair neovascularization. were pretreated with or without anti-CXCR4 blocking antibody combined CM-DiI label, injected via tail vein into mice full-thickness skin wounds on dorsum. Simultaneously,...
Dynamic contrast-enhanced MRI (DCE-MRI) estimates vascular permeability of brain tumors, and susceptibility-weighted imaging (SWI) may demonstrate tumor vascularity by intratumoral susceptibility signals (ITSS). This study assessed volume transfer constant (Ktrans) accuracy, the extravascular extracellular space (EES) per unit tissue (Ve) derived from DCE-MRI, degree ITSS in glioma grading. Thirty-two patients with different grades were enrolled this retrospective study. Patients underwent...
Abstract Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on immune function sepsis, an expert consensus focusing monitoring treatment sepsis-induced was developed. Literature related to sepsis were retrieved from PubMed, Web Science, Chinese National Knowledge Infrastructure design items opinions collected through online questionnaire. Then, Delphi method used form opinions, RAND...
Abstract Hormesis, an adaptive response, occurs when exposure to low doses of a stressor potentially induces stimulatory effect, while higher may inhibit it. This phenomenon is widely observed across various organisms and stressors, significantly advancing our understanding inspiring further exploration the beneficial effects toxins at both below beyond traditional thresholds. has profound implications for promoting biological regulation cellular level enhancing adaptability throughout...
Abstract Bismuth telluride (Bi 2 Te 3 ) has been the only commercialized material in thermoelectric cooling and waste heat recovery. However, inferior performance for n‐type Bi (Te, Se) largely restricts practical applications. In this study, additional Ag atoms are introduced utilizing lattice plainification strategy to enhance electrical performance. Observations indicate that situate van der Waals layers, acting as dopants increase carrier concentration, bonding with adjacent...
SnSe crystal has witnessed significant advancements as a promising thermoelectric material over the past decade. Its in-plane direction shows robust mechanical strength for practical applications. Herein, we optimize performance of n-type by symmetry modification. In particular, find that Te and Mo alloying continuously enhances symmetry, thereby increasing carrier mobility to ~ 422 cm2 V-1 s-1. Simultaneously, conduction bands converge with modification, further improving electrical...
Uveitis is characterized as a common cause of blindness worldwide. Aryl hydrocarbon receptor (AhR), ligand-activated nuclear receptor, has been implicated to play role in human uveitis, although the exact mechanisms remain poorly understood. The purpose this study was enhance our knowledge concerning AhR during intraocular inflammation. We immunized wild type and knockout C57BL/6J mice with IRBP651-670 induce experimental autoimmune uveitis (EAU). Disease severity evaluated both clinical...
Background: Innate immune memory, also termed "trained immunity", is thought to protect against experimental models of infection, including sepsis.Trained immunity via reprogramming monocytes/ macrophages has been reported result in enhanced inflammatory status and antimicrobial activity infection sepsis.However, a safe efficient way induce trained remains unclear.Methods: β-glucan prototypical agonist for inducing immunity.Ferumoxytol, superparamagnetic iron oxide (SPIO) with low...
Sepsis-associated acute kidney injury (SA-AKI) is one of the most frequent and serious complications sepsis. However, transcriptional regulatory network pathophysiological mechanism has not been revealed. This study identified new mechanisms in SA-AKI using bioinformatics analyses laboratory-based experiments.We performed transcriptomic profiling mouse kidneys after cecal ligation puncture (CLP) to mimic clinical RNA from samples CLP control groups was isolated analyzed bulk messenger...
Thermoelectrics can mutually convert between thermal and electrical energy, ensuring its utilization in both power generation solid-state cooling. Bi2Te3 exhibits promising room-temperature performance, making it the sole commercially available thermoelectrics to date. Guided by lattice plainification strategy, we introduce trace amounts of Cu into n-type Bi2(Te, Se)3 (BTS) occupy Bi vacancies, thereby simultaneously weakening defect scattering modulating electronic bands. Meanwhile,...
Macrophages are key responders of inflammation and closely related with oxidative stress. Activated macrophages can enhance oxygen depletion, which causes an overproduction reactive species (ROS) leads to further excessive inflammatory response tissue damage. Agmatine, endogenous metabolite L-arginine, has recently been shown have neuroprotective effects based on its antioxidant properties. However, the agmatine in peripheral tissues cells, especially macrophages, remain unclear. In this...
Abstract The therapeutic effect of mesenchymal stem cells (MSCs) on sepsis has been well-known. However, a comprehensive understanding the relationship between MSCs and macrophages remains elusive. Superparamagnetic iron oxide (SPIO) is one most commonly used tracers for MSCs. Our previous study shown that SPIO enhanced in macrophage-dependent manner. fate SPIO-labeled (MSC ) after infusion unknown direct interaction MSC unclear. Mice were injected intravenously with at 2 h Escherichia coli...
Nuclear factor-κB (NF-κB) is a central regulator of immune response and potential target for developing anti-inflammatory agents. Mechanistic studies suggest that compounds directly inhibit NF-κB DNA binding may block inflammation the associated tissue damage. Thus, we attempted to discover peptides could interfere with signaling based on highly conserved DNA-binding domain found in all members. One such small peptide, designated as peptide-6 (AIP6), was characterized current study. AIP6...
Evodiamine, one of the major bioactive components derived from Wu-Chu-Yu, a long-standing Chinese herb, was reported to possess anticancer activity. In this study, we investigated in-vitro and in-vivo effects evodiamine on human colon lovo cells their potential mechanisms. The 3-(4, 5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay showed that proliferation inhibited by various concentrations. Flow cytometry time-dependent increase in percentage apoptotic arrested S phase after...