A5100708612- Advanced Glycation End Products research
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Sarcoidosis and Beryllium Toxicity Research
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Breast Lesions and Carcinomas
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immune cells in cancer
- Hedgehog Signaling Pathway Studies
- Neonatal Health and Biochemistry
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
First Affiliated Hospital of Xi'an Jiaotong University
2021-2025
Fudan University
2020-2024
Peking University People's Hospital
2021-2024
Peking University
2021-2024
Xijing Hospital
2021-2024
Air Force Medical University
2021-2024
First Affiliated Hospital of Soochow University
2021-2024
Xi'an Jiaotong University
2021-2024
Soochow University
2021-2024
Xi'an Honghui Hospital
2024
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, precise mechanism by which metabolic reprogramming regulates inflammatory response is unclear. Here we show that aerobic glycolysis contributes modulating inflammasome activation macrophages. PKM2-mediated promotes EIF2AK2 phosphorylation Pharmacological genetic inhibition PKM2 or attenuates NLRP3 AIM2 inflammasomes activation,...
PML-RARα oncoprotein is a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-α (RARα) causes acute leukemias (APL). A hallmark all-trans (ATRA) responses in APL degradation which promotes cell differentiation. Here, we demonstrated that autophagy crucial regulator degradation. Inhibition by short hairpin (sh) RNA target essential genes such as Atg1, Atg5 PI3KC3 inhibitors (e.g. 3-methyladenine), blocked subsequently granulocytic differentiation human myeloid...
As a highly invasive carcinoma, esophageal cancer (EC) was the eighth most prevalent malignancy and sixth leading cause of cancer-related death worldwide in 2020. Esophageal squamous cell carcinoma (ESCC) is major histological subtype EC, its incidence mortality rates are decreasing globally. Due to lack specific early symptoms, ESCC patients usually diagnosed with advanced-stage disease poor prognosis, still high many countries, especially China. Therefore, enormous challenges exist...
Background There have been limited treatment therapies for lung squamous cell carcinoma (LUSC). M6A-related genes may be the next therapeutic targets LUSC. In this study, we explored prognostic role and mutational characteristics of m6A-related in Methods LUSC gene expression data, corresponding clinical information were extracted from The Cancer Genome Atlas database. Differentially expressed (DEGs) identified, mutation patients explored. Then, correlations among detected. Finally, roles...
The aim of the present study was to investigate in vivo effect high-mobility group box 1 protein (HMGB1) on activity regulatory T cells (Tregs) and influence T-cell-mediated immunity after thermal injury. Male Wistar rats were randomly divided into four groups as follows: sham burn group, with ethyl pyruvate treatment antireceptor for advanced glycation end products (RAGE) antibody they killed postburn days 1, 3, 5, 7, respectively, eight animals at each time point. Magnetic cell sorting...
Disruption of mitochondrial dynamics is an important pathogenic event in both acute and chronic kidney diseases, but the underlying mechanism remains poorly understood. Here, we report regulation mitofusin-2 (Mfn2; a key fusion protein) by microRNA-214 (miR-214) renal ischemia-reperfusion that contributes to fragmentation, tubular cell death, ischemic injury (AKI). miR-214 was induced, whereas Mfn2 expression decreased, mouse AKI cultured rat proximal cells (RPTCs) following ATP depletion...
The breast cancer specific survival (BCSS) benefits of Neoadjuvant therapy (NeoAT) for triple-negative metaplastic (TNMpBC) was uncertain. This study aimed to develop a prediction model assessing the BCSS TNMpBC patients with NeoAT. primary cohort 1163 TNMpBC, from which nomogram established based on results LASSO regression analysis, derived multi-centers data in China and SEER database. further validated by an independent 155 NeoAT, discrimination calibration assessed. Totally (13.3%)...
Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands TAM receptors (Tyro3, Axl, and Mertk), its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for active suppression autoimmunity. The present study was designed to investigate whether Tregs express potential Gas6-TAM signal in regulating suppressive function Tregs. Methods. protein mRNA levels were determined by using Western blot,...
Signal transduction mechanism in the regulation of high mobility group box protein 1 (HMGB1) has not yet been well elucidated. Our data showed for first time that Janus kinase-signal and activator transcription (JAK/STAT) pathway played a major role expression inflammatory effect HMGB1. The study was carried out following sequence. Firstly, JAK/STAT HMGB1 examined. After stimulation with 75 ng/mL LPS vitro, significant increases prompt activation were demonstrated cultured macrophages. On...
There has been a widespread impression that tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) mediate the toxicity of high doses lipopolysaccharide (LPS, endotoxin) are key factors in septic shock. However, clinical efficacy treatment with antagonists TNF-α IL-1β is still controversial, suggesting mediators other than might contribute causally to endotoxin-induced death. Recent studies implicated mobility group-1 (HMG-1) protein as late mediator endotoxin lethality mice. role HMG-1...
High mobility group box-1 protein (HMGB1), a recently described late-acting cytokine that mediates lethality of sepsis and systemic inflammation, also plays role in mediating dendritic cell (DC) maturation activation. The present study was performed to clarify the effects HMGB1 on splenic DCs its potential regulating mechanism underlying T-cell-mediated immunity. isolated from spleens normal rats were treated with different dosage (0.1, 1, or 10 μg/mL) for duration (24, 48, 72 h)....
We assessed the potential role of serial circulating tumor DNA (ctDNA) as a biomarker to monitor treatment response primary systemic therapy (PST) in breast cancer and evaluated predictive value ctDNA further identify patients with residual disease.
Acute renal injury (ARI) is a life‑threatening condition and main contributor to end‑stage disease, which mainly caused by ischemia‑reperfusion (I/R). miR‑106b‑5p kidney function‑related miRNA; however, whether regulates the progression of ARI remains unclear. The present study thus aimed examine effects antagonist on regulation progression. It was found that expression upregulated in tissue rats with I/R‑induced NRK‑52E rat proximal tubular epithelial cells subjected hypoxia‑reoxygenation...
High mobility group box 1 protein (HMGB1), a critical proinflammatory cytokine, has recently been identified to be an immunostimulatory signal involved in sepsis-related immune dysfunction when released extracellularly, but the potential mechanism remains elusive. Here, we showed that treatment with HMGB1 vitro inhibited T lymphocyte response and expression of mitofusin-2 (Mfn-2; member mitofusin family) dose- time-dependent manner. Upregulation Mfn-2 attenuated suppressive effect on cell...