A5046595961- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced Fluorescence Microscopy Techniques
- Organic Electronics and Photovoltaics
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Porphyrin and Phthalocyanine Chemistry
- Perovskite Materials and Applications
- Supercapacitor Materials and Fabrication
- Photoreceptor and optogenetics research
- Analytical Chemistry and Sensors
- Wind and Air Flow Studies
- Sulfur Compounds in Biology
- Lipid Membrane Structure and Behavior
- Catalytic Processes in Materials Science
- Photochromic and Fluorescence Chemistry
- Nonlinear Optical Materials Studies
- Organic Light-Emitting Diodes Research
- Nitric Oxide and Endothelin Effects
- Photosynthetic Processes and Mechanisms
- Carbon Dioxide Capture Technologies
- Electrochemical Analysis and Applications
- Seismic Performance and Analysis
- Click Chemistry and Applications
Dalian University of Technology
2015-2024
Dalian University
2015-2024
North China Electric Power University
2017-2024
CeMM Research Center for Molecular Medicine
2024
Austrian Academy of Sciences
2024
University of Vienna
2024
Hebei Normal University
2024
Lanzhou University
2023
Guilin University of Technology
2023
East China University of Science and Technology
2003-2019
Mercury rising: A FRET-based ratiometric probe (see picture; FRET=fluorescence resonance energy transfer) can selectively detect Hg2+ ions on the parts-per-billion scale under physiological conditions. The undergoes a clear Hg2+-induced change in intensity ratio of two well-separated and equally intense emission bands dipyrrometheneboron difluoride rhodamine. Experiments show that be used living cells.
A Cu(II)-sensing, ratiometric, and selective fluorescent sensor 1, N-butyl-4,5-di[(pyridin-2-ylmethyl)amino]-1,8-naphthalimide, was designed synthesized on the basis of mechanism internal charge transfer (ICT). In aqueous ethanol solutions presence Cu(II) induces formation a 1:1 metal-ligand complex, which exhibits strong, increasing emission centered at 475 nm expense 1 525 nm. [structure: see text]
A lysosome-specific and two-photon fluorescent probe, Lyso-NINO, demonstrates high selectivity sensitivity toward NO, lower cytotoxicity, perfect lysosomal localization. With the aid of first capture NO within lysosomes macrophage cells has been achieved using both fluorescence microscopy flow cytometry.
We have developed Lyso-V, the first fluorescent probe of lysosomal viscosity. Because its lysosome-actived fluorescence characteristics, Lyso-V has proved to be an ideal tracer with high spatial and temporal resolution under laser confocal microscopy. More importantly, shows practical applicability in real-time quantification viscosity changes live cells through lifetime imaging
In this feature article, we report our recent progresses in fluorescent sensors of biological dyes from the viewpoint supramolecular and bioorganic chemistry. For signalling fluorophores, extended or created naphthalene-based ICT systems, e.g. amino-1,8-naphthalimides, amino-1,8-dicyanonaphthalenes acenaphthopyrrol-9-carbonitriles. We also developed BODIPY derivatives with large Stokes shifts high fluorescence quantum yields polar solvents, a rhodamine analogue working strong competitive...
Insufficient brightness of fluorophores poses a major bottleneck for the advancement super-resolution microscopes. Despite being widely used, many rhodamine dyes exhibit sub-optimal due to formation twisted intramolecular charge transfer (TICT) upon photoexcitation. Herein, we have developed new class quaternary piperazine-substituted rhodamines with outstanding quantum yields (Φ = 0.93) and superior (ε × Φ 8.1 104 L·mol–1·cm–1), by utilizing electronic inductive effect prevent TICT. We also...
Small molecular dye that simultaneously exerts dual PDT/PTT effects as well florescence imaging triggered by a single NIR-II light has never been reported to date. Apart from the huge challenge in pushing absorption profile into region, fine-tuning dyes' excited state via rational structure design meet all three functions, especially oxygen photosensitization, remains most prominent throttle. Herein, five novel dyes (BHs) are productively developed strategically conjugating dyad innovative...
Replacement of the oxygen with a silicon atom on rhodamine framework produces strong red-emission fluorophore which has high molar extinction coefficient and 90 nm red shift relative to dye PY.
Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for detection microenvironment was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) results in an evident blue to green emission wavelength change both solution phases cell lines, which might first probe solid tumors.
Near-infrared (NIR) fluorescent probes are increasingly popular in biological imaging and sensing, as long-wavelength (650-900 nm) excitation emission have the advantages of minimum photodamage, deep tissue penetration, interference from autofluorescence living systems. Here, a series BODIPY dyes SPC, DC-SPC, DPC, DC-DPC synthesized conveniently efficiently. They exhibit excellent photophysical properties far red to near-infrared region, including large extinction coefficients, high...
Bulky 4-tritylphenylethynyl substituted boradiazaindacene with pure red emission, relatively large Stokes shift, high fluorescence quantum yield, and low self-quenching was efficiently synthesized qualified as a potential EL dopant.
Novel isomeric fluorine−boron complexes with donor−acceptor architecture have been efficiently synthesized and well characterized. Significant features, such as strong solid liquid fluorescence, unusual large Stokes shifts, lower LUMO levels higher HOMO levels, are observed in these potential multifunctional molecules.
A light-harvesting system containing three kinds of BODIPY fluorophores was synthesized. It exhibited very strong absorption in the region from 300 to 700 nm, and energy transfer within it highly efficient.
Abstract We have connected a borondipyrromethene (BODIPY) donor to the 5′ position of tetramethylrhodamine (TMR) acceptor form high efficiency (over 99 %) intramolecular fluorescence resonance energy transfer (FRET) cassette, BODIPY–rhodamine platform (BRP). While good spectral overlap between emission BODIPY and absorption TMR was one favorable factor, another feature this FRET system rigid short biphenyl spacer that favored efficient through‐bond transfer. More importantly, in system,...
In the orignial 1,3,5,7-tetraphenyl aza-BODIPY, replacing phenyl rings with thiophene achieved significant bathochromic shifts. One of target molecules, DPDTAB, emitting strong NIR fluorescence a quantum yield 0.46 in acetonitrile, is very competitive fluorophore.
By comparison and combination of two strategies, extending π-conjugation tuning Intramolecular Charge Transfer (ICT) effect, new long-wavelength BODIPY dyes have been efficiently synthesized. The chromophores exhibit good optical properties: high fluorescence quantum yields, exceptionally large molar extinction coefficients, narrow red-emission bands, relatively Stokes shifts etc., in polar or apolar solvents. Besides, the dyes, under transversal pumping at 532 nm, highly efficient stable...
Two-photon excitable (850 nm) NIR fluorescent turn-on (702 probe TP-NIR was synthesized for selective detection of cysteine (Cys). The itself shows is turned on by reaction with Cys in aqueous buffer. In addition, the displays greater selectivity over other thiols, including glutathione (GSH) and homocysteine (Hcy). Moreover, large Stokes shift, excitation, emission make this suitable biological imaging.
Rhodamine derivatives and analogues have been widely used for different super-resolution imaging techniques, including photoactivated localization microscopy (PALM). Among them, rhodamine spirolactams exhibit great superiority PALM due to a desirable bright–dark contrast during the photochromic switching process. Although considerable attention has paid chemical modifications on spirolactams, on-time of switching, one key characteristics imaging, never optimized in previous developments. In...
Nitric oxide (NO) is a ubiquitous cellular messenger molecule in the cardiovascular, nervous, and immune systems. Mitochondrion main area where endogenous NO synthesized by inducible NOS enzymes mammalian cells. Thus, real-time monitoring mitochondria very meaningful for chemical biology. Although variety of fluorescent probes have been successfully developed, they are not suited detecting mitochondrial because none them can specifically localize mitochondria. Herein, Mito-Rh-NO, first...
It is meaningful to accurately quantify the changes in local viscosity within mitochondria of living cells, because influences mitochondrial network organization and metabolite diffusion. Although many molecular probes targeting have been reported, almost all them are not fixed mitochondria. Thus, they may be suitable for sensing abnormal with lowered potential. In order monitor mitochondria, no matter their working or health status, we develop first fixable BODIPY (boron-dipyrromethene)...
Restoring innate apoptosis and simultaneously inhibiting metastasis by a molecular drug is an effective cancer therapeutic approach. Herein, large rigid V-shaped NIR-II dye, DUT850, rationally designed for potential cardiolipin (CL)-targeted chemo-phototheranostic application. DUT850 displays moderate fluorescence, excellent photodynamic therapy (PDT) photothermal (PTT) performance, ultra-high photostability. More importantly, the unique backbone, positive charge, lipophilicity of afford its...
Sulfoxide-bridged dimeric BODIPYs were developed as a new class of long-wavelength photoconvertible fluorophores. Upon visible-light irradiation, sulfoxide moiety was released to generate the corresponding α,α-directly linked BODIPYs. The extrusion SO from sulfoxides mainly through an intramolecular fashion involving reactive triplet states. By this photoconversion, not only more than 100 nm red shifts absorption and emission maxima (up 648/714 nm) achieved but also stable products with...