A5101519735- Fibroblast Growth Factor Research
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cholinesterase and Neurodegenerative Diseases
- Ubiquitin and proteasome pathways
- Consumer Behavior in Brand Consumption and Identification
- Mental Health and Well-being
- Simulation-Based Education in Healthcare
- Advanced Electron Microscopy Techniques and Applications
- Family Caregiving in Mental Illness
- Computational Drug Discovery Methods
- Biochemical Acid Research Studies
- Global Maternal and Child Health
- Healthcare Policy and Management
- CAR-T cell therapy research
- Healthcare Systems and Reforms
- Advanced Fluorescence Microscopy Techniques
- Kruppel-like factors research
- Viral gastroenteritis research and epidemiology
- Innovative Educational Techniques
- Schizophrenia research and treatment
- Plant Gene Expression Analysis
Xi'an Jiaotong University
2024
Yale University
2022-2023
Affiliated Hospital of Youjiang Medical University for Nationalities
2021
Guangdong University of Petrochemical Technology
2020
Liaoning University
2019
Sun Yat-sen University
2015-2018
Rhodamine derivatives and analogues have been widely used for different super-resolution imaging techniques, including photoactivated localization microscopy (PALM). Among them, rhodamine spirolactams exhibit great superiority PALM due to a desirable bright–dark contrast during the photochromic switching process. Although considerable attention has paid chemical modifications on spirolactams, on-time of switching, one key characteristics imaging, never optimized in previous developments. In...
Herein, the clustered regularly interspaced short palindromic repeats (CRISPRs)/CRISPRs-associated protein 9 (Cas9) technology for genome editing was used to develop an efficient gene system Eucalyptus urophylla × grandis and generate a new germplasm with reduced lignin content in pulp environmental sustainability papermaking. By targeting cinnamate-4-hydroxylase (C4H) E. grandis, recombinant plasmid pHEE401E-35S-RUBY-EuC4H constructed through homologous recombination. This then transformed...
Because of the complexity Alzheimer's disease (AD), multi-target-directed ligand (MTDL) strategy is expected to provide superior effects for treatment AD, instead classic one-drug-one-target strategy. In this context, we focused on design, synthesis and evaluation homoisoflavonoid derivatives as dual acetyl cholinesterase (AChE) monoamine oxidase (MAO-B) inhibitors. Among all synthesized compounds, compound 10 provided a desired balance AChE hMAO-B inhibition activities, with IC50 value 3.94...
A novel series of boron-containing compounds were designed, synthesized and evaluated as multi-target-directed ligands against Alzheimer's disease.
Abstract Squamous cell carcinoma of the head and neck (HNSCC) is sixth most prevalent cancer worldwide, with an annual incidence 600,000 new cases. Despite advances in surgery, chemotherapy, radiotherapy, overall survival for HNSCC patients has not been significantly improved over past several decades. Fibroblast growth factor (FGF)/fibroblast receptor (FGFR) genomic alterations are frequently detected HNSCC, including amplification, activating mutation, chromosomal rearrangement. Among...
The Family Doctor Contract Service (FDCS) system is a service model for primary care reform launched in 2016 to offer families and individuals active continuous health by team of family doctors within institutions China.
Abstract Intrahepatic cholangiocarcinoma (ICC) remains a deadly malignancy lacking systemic therapies for advanced disease. Recent advancements include selective FGFR1–3 inhibitors the 15% of ICC patients harboring fusions, although survival is limited by poor response and resistance. Herein we report generation patient-derived FGFR2 fusion-positive model system consisting cell line, organoid, xenograft, which have undergone complete histologic, genomic, phenotypic characterization,...
Abstract Bladder cancer (BC) is one of the most prevalent malignancies worldwide and FGFR3 alterations are particularly common in BC. Despite approval erdafitinib, durable responses for FGFR inhibitors still uncommon patients relapse to metastatic disease. Given necessity discover more efficient therapies BC, herein, we sought explore promising synergistic combinations BC with fusions. Our studies confirmed synergy between HDAC vitro demonstrated its benefits vivo. Mechanistic revealed that...
APOBEC3 family members are cytidine deaminases catalyzing conversion of to uracil. Many studies have established a link between expression and cancer development progression, especially APOBEC3A (A3A) APOBEC3B (A3B). Preclinical with human papillomavirus positive (HPV+) head neck squamous cell carcinoma (HNSCC) clinical trial specimens revealed induction A3B, but not A3A after demethylation. We examined the kinetic features deaminase activity for full length A3B found that longer substrates...
Unplanned readmissions among patients with mental and behavioural disorders (MBDs) disrupt inpatient recovery impose financial burdens on families healthcare systems. To estimate the 31-day unplanned readmission rates for MBDs in China identify determinant profiles from perspective of individual, hospital, contextual levels. Data were collected medical records 99 public hospitals across 10 cities. A total 49,352 admissions analysed based proposed conceptual model using multilevel logistic...
Objective To examine the practical effect of inter-professional education and situational simulation teaching implemented in surgical nursing practice teaching. Methods On whole, 100 undergraduate students operating room hospital authors from May 2019 to August 2020 were selected. These fell two groups with random number table method. The control received regular teaching, research group given interprofessional context. Simulation was conducted compare theoretical knowledge, skill level,...
APOBEC3 family members are cytidine deaminases catalyzing conversion of to uracil. Many studies have established a link between expression and cancer development progression, especiallyAPOBEC3A (A3A) APOBEC3B(A3B). Here, we explored the kinetic features full length A3B found that longer substrates purine at -2 position more favored by A3B, whereas A3A) prefers shorter an adenine or thymine site. The clinical relevance sequence preference A3A was pan bioinformatic analysis using TCGA...