A5101986718- Pancreatic and Hepatic Oncology Research
- Olfactory and Sensory Function Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Seismology and Earthquake Studies
- Anomaly Detection Techniques and Applications
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Liver Disease and Transplantation
- Dialysis and Renal Disease Management
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Neurological Complications and Syndromes
- Glycosylation and Glycoproteins Research
- Service-Oriented Architecture and Web Services
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect Pheromone Research and Control
- Gastric Cancer Management and Outcomes
- Glaucoma and retinal disorders
- Electrolyte and hormonal disorders
- Software Engineering Research
Duke Medical Center
2022-2025
NYU Langone Health
2025
Massachusetts General Hospital
2023-2024
Harvard University
2023-2024
Duke University
2022-2024
Brigham and Women's Hospital
2023-2024
Durham Technical Community College
2023
University Health Network
2021
Center for the Neural Basis of Cognition
2016-2020
University of Pittsburgh
2014-2020
Here we show that conditional deletion of Pten in a subpopulation adult neural stem cells the subependymal zone (SEZ) leads to persistently enhanced cell self-renewal without sign exhaustion. These null SEZ-born and progenies can follow endogenous migration, differentiation, integration pathways contribute constitutive neurogenesis olfactory bulb. As result, deleted animals have increased bulb mass function. establish normal connections with peripheral epithelium help recovery from acute...
The article describes the design of Community Seismic Network, which is a dense open seismic network based on low cost sensors. inputs are from sensors hosted by volunteers community direct connection to their personal computers, or through built into mobile devices. server cloud-based for robustness and dynamically handle load impulsive earthquake events. main product map peak acceleration, delivered within seconds ground shaking. lateral variations in level shaking will be valuable first...
Stroke and heart disease are the most serious complications of diabetes accounting for >65% mortality among diabetics. Although intensive insulin therapy has significantly improved prognosis its complications, it is associated with an elevated risk recurrent hypoglycemia (RH). We tested hypothesis that RH exacerbates cerebral ischemic damage in a rodent model diabetes.We determined extent neuronal death CA1 hippocampus after global ischemia control streptozotocin-induced diabetic rats....
The Caltech CSN project collects sensor data from thousands of personal devices for real-time response to dangerous earthquakes.
Navigating an odor landscape is a critical behavior for the survival of many species, including mice. An ethologically relevant mouse locating food using information about concentration. To approximate this behavior, we used open field odor-based spot-finding task indoors with little wind, examining navigation strategies as mice search and approach source. After were trained to navigate sources paired reward, observed behavioral changes consistent localization 10-45 cm away from These...
In the main olfactory bulb (MOB), first station of sensory processing in system, GABAergic interneuron signaling shapes principal neuron activity to regulate olfaction. However, a lack known selective markers for MOB interneurons has strongly impeded cell-type-selective investigation function. Here, we identify marker glomerular layer-projecting deep short-axon cells (GL-dSACs) and investigate systematically structure, abundance, intrinsic physiology, feedforward input, neuromodulation,...
The highly specific organization of the olfactory bulb (OB) is well known, but impact early odorant experience on its circuit structure unclear. Olfactory sensory neurons (OSNs) project axons from epithelium to OB, where they form spherical neuropil structures called glomeruli. These glomeruli and postsynaptic targets OSNs, including mitral tufted cells (M/TCs) juxtaglomerular cells, glomerular modules, which represent basic odor-coding units OB. Here, we labeled M/TCs within a single module...
Abstract Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated in human cancers, yet strategies its downstream signaling kinases have failed to produce durable treatment responses. Here, we developed multiple models of acquired dual-mechanism ERK/MAPK inhibitors across -mutant pancreatic, colorectal, and lung then probed long-term events enabling survival against this class drugs. These studies revealed that...
Abstract Background A growing number of centers offer hepatic artery infusion pump (HAIP) chemotherapy for advanced liver malignancies. While small series have demonstrated feasibility robotic HAIP placement, comparison outcomes with open placement is lacking. We compared after versus placement. Methods retrospectively reviewed without concurrent hepatectomy at Memorial Sloan Kettering Cancer Center from 1 January 2011 to 15 September 2022, and Duke Health November 2018 18 May 2023. Patients...
The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly Migraine with Aura. Migraine, and without aura (MA MO) have many diagnostic characteristics common. It is postulated that symptomatic might themselves be influenced by MTHFR. Here we analysed the clinical profile, symptoms, triggers treatments of 267 migraineurs previously genotyped for MTHFR variant. chi-square test was used to analyse all...
Abstract Early sensory experience shapes the anatomy and function of circuits. In mouse olfactory bulb (OB), prenatal early postnatal odorant exposure through odorized food (food/odorant pairing) not only increases volume activated glomeruli but also number mitral tufted cells (M/TCs) connected to glomeruli. Given importance M/TCs in OB output mediating lateral inhibitory networks, increasing a single glomerulus may significantly change representation by total that and/or strength inhibition...
Evidence has long suggested that epidermal growth factor receptor (EGFR) may play a prominent role in triple-negative breast cancer (TNBC) pathogenesis, but clinical trials of EGFR inhibitors have yielded disappointing results. Using candidate drug screen, we identified inhibition cyclin-dependent kinases 12 and 13 (CDK12/13) dramatically sensitizes diverse models TNBC to blockade. This combination therapy drives cell death through the 4E-BP1-dependent suppression translation...
Objective: To create a blueprint for surgical department leaders, academic institutions, and funding agencies to optimally support surgeon-scientists. Summary Background Data: Scientific contributions by surgeons have been transformative across many medical disciplines. Surgeon-scientists provide distinct approach mindset toward key scientific questions. However, lack of institutional support, pressure increased clinical productivity growing administrative burden are major challenges the...
Human mesenchymal stem cells (hMSC) are being administered by direct intramyocardial (IM) injection into patients with myocardial dysfunction an objective to improve clinical status. However, surprisingly little attention has been directed qualifying hMSC functionality beyond simple viability. In particular, the transit of hMSCs through a small-caliber needle lumen, final fluidic pathway for all IM devices, may be especially prone inducing unwarranted effects on cell function. This study...
Abstract Intrahepatic cholangiocarcinoma (ICC) remains a deadly malignancy lacking systemic therapies for advanced disease. Recent advancements include selective FGFR1–3 inhibitors the 15% of ICC patients harboring fusions, although survival is limited by poor response and resistance. Herein we report generation patient-derived FGFR2 fusion-positive model system consisting cell line, organoid, xenograft, which have undergone complete histologic, genomic, phenotypic characterization,...