A5103115430- Pharmacogenetics and Drug Metabolism
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Sepsis Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- RNA modifications and cancer
- Pneumonia and Respiratory Infections
- Hematological disorders and diagnostics
- Chronic Myeloid Leukemia Treatments
- Pancreatic and Hepatic Oncology Research
- Neonatal and Maternal Infections
- Pediatric Urology and Nephrology Studies
- Cancer Treatment and Pharmacology
- Pharmaceutical studies and practices
- Colorectal Cancer Treatments and Studies
- Genetic Associations and Epidemiology
- Viral-associated cancers and disorders
- Neonatal Respiratory Health Research
- Gastric Cancer Management and Outcomes
- Thermal Regulation in Medicine
- Cancer-related Molecular Pathways
- Drug-Induced Adverse Reactions
- Drug Transport and Resistance Mechanisms
KK Women's and Children's Hospital
2022-2024
National University of Singapore
2023
National Cancer Centre Singapore
2013-2023
SingHealth
2013-2019
Singapore General Hospital
2013
The therapeutic efficacy of tamoxifen is predominantly mediated by its active metabolites 4-hydroxy-tamoxifen and endoxifen, whose formation catalyzed the polymorphic cytochrome P450 2D6 (CYP2D6). Yet, known CYP2D6 polymorphisms only partially determine metabolite concentrations in vivo. We performed first cross-ancestry genome-wide association study with well-characterized patients European, Middle-Eastern, Asian descent (n = 497) to identify genetic factors impacting parent formation....
Evidence has long suggested that epidermal growth factor receptor (EGFR) may play a prominent role in triple-negative breast cancer (TNBC) pathogenesis, but clinical trials of EGFR inhibitors have yielded disappointing results. Using candidate drug screen, we identified inhibition cyclin-dependent kinases 12 and 13 (CDK12/13) dramatically sensitizes diverse models TNBC to blockade. This combination therapy drives cell death through the 4E-BP1-dependent suppression translation...
Differentiating infants with serious bacterial infections (SBIs) or invasive (IBIs) from those without remains a challenge. We sought to compare the diagnostic performances of single biomarkers (absolute neutrophil count [ANC], C-reactive protein [CRP] and procalcitonin [PCT]) 4 approaches comprising Lab-score, Step-by-Step approach (original modified) Pediatric Emergency Care Applied Research Network (PECARN) rule.This is prospective cohort study involving 0-90 days age who presented an...
The use of imatinib in the treatment BCR-ABL-positive chronic myeloid leukemia and gastrointestinal stromal tumors has significantly improved survival outcomes patients afflicted by these malignancies. However, a substantial proportion imatinib-treated still experience failure. Suboptimal concentrations have been postulated to contribute at least partially development resistance against imatinib. Indeed, variations genes encoding drug transporters reported markedly influence disposition...
Febrile young infants are at risk of serious bacterial infections (SBIs), which potentially life-threatening. This study aims to investigate the association between delayed presentation and SBIs among febrile infants.
e15722 Background: Gemcitabine plus erlotinib (G+E) is the standard of care for treatment patients with pancreatic ductal adenocarcinoma (PDAC). The FOLFIRINOX regimen was shown to significantly improve survival PDAC over gemcitabine but occurred at expense significant toxicities, highlighting crucial need more effective options that are tolerable. This study sought investigate effects oxaliplatin, xeloda and irinotecan (OXIRI) versus G+E in cell lines. Methods: anti-proliferative drug...