A5029453742- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Hernia repair and management
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Viral-associated cancers and disorders
- Breast Cancer Treatment Studies
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Palliative Care and End-of-Life Issues
- Cancer therapeutics and mechanisms
- Gastric Cancer Management and Outcomes
- Endometrial and Cervical Cancer Treatments
- Meningioma and schwannoma management
- Acute Lymphoblastic Leukemia research
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Statistical Methods in Clinical Trials
- Glioma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
Institut National d'Oncologie
2024
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Policlinico Abano Terme
2024
Hospices Civils de Lyon
2024
Ospedale Policlinico San Martino
2024
University of Messina
2024
National Cancer Centre Singapore
2014-2023
Binus University
2023
National University of Singapore
2018
Abstract Background The impact and consequences of cancer on the patients their family caregivers (FCs) are closely intertwined. Caregivers’ burdens can be increased due to patients’ unmet needs unresolved problems. Additionally, caregivers’ may adversely affect own well-being health outcomes. This study aims determine palliative care factors associated with these in advanced solid FCs. Methods In a cross-sectional survey, 599 tumours FCs were recruited from largest ambulatory centre...
Asians are diagnosed with breast cancer at a younger age than Caucasians are. We studied the effect of on locoregional recurrence and survival Asian patients treated breast-conserving therapy.Medical records 2492 therapy between 1989 2012 were reviewed. The Kaplan-Meier method was used to estimate recurrence, cancer-free survival, cancer-specific rates. These rates then compared using log-rank tests. Outcomes modeled by Cox proportional hazards. Fractional polynomials test for non-linear...
Background: The majority of patients with hepatocellular carcinoma (HCC) are inoperable and results conventional chemotherapy dismal. Many end up no treatment options resort to alternative medicine. authors report the use Coriolus versicolor (CV) in advanced HCC poor liver function or who were unfit receive standard therapy. Methods: Fifteen eligible cases randomized 2:1 either CV placebo. primary endpoint was median time progression (TTP) between both arms. Secondary endpoints include...
Statins, HMG-CoA reductase inhibitors, are commonly used cholesterol-lowering medications which also increasingly recognized to have anti-cancer properties for various cancers, including breast cancer. Most clinical evidence supports a protective effect of statin on reducing cancer recurrence, particularly in hormone-receptor positive cancers.This study seeks the impact use recurrence an Asian population.This is retrospective patients diagnosed with at National Cancer Centre and Singapore...
Objectives This purpose of this study was to examine clinical-pathologic factors – particularly smoking and brain metastases in EGFR mutation positive (M+) lung adenocarcinoma (ADC) determine their impact on survival patients treated with first line TKI. Methods A retrospective review reflex testing experience for all ADC diagnosed at a tertiary Asian cancer centre from January 2009 April 2013. Amongst cohort, advanced M+ TKI were identified that influence progression free overall survival....
Abstract Background To evaluate changes in xerostomia status, salivary characteristics and gland volumes 2 years following radiotherapy nasopharyngeal carcinoma patients. Methods Xerostomia scores, flow rates, pH buffering capacity were measured at pre‐radiotherapy, mid‐radiotherapy, weeks, 3 months post‐radiotherapy. Salivary their correlation with radiation dose also assessed. Results Mean to oral cavity, parotid submandibular glands (SMG) was 44.5, 65.0 38.6 Gy respectively. Parotid SMG...
Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of nonsmall cell lung cancer (NSCLC) predominantly reported in East Asia. We aimed to evaluate clinical characteristics, diagnosis, treatment, and prognosis PPLELC Singapore.Retrospective review all patients diagnosed with at our center between 2000 2014.All 28 were Chinese, 67.9% female, the median age was 58 years (range37-76 years). Majority (89.3%) never smokers 53.6% asymptomatic diagnosis. About 28.6%...
Afatinib is an oral irreversible epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) indicated in first-line treatment of advanced EGFR-mutant (EGFRm+) non-small cell lung cancer (NSCLC). Dose dependent side effects can limit drug exposure, which may impact on extracranial and central nervous system (CNS) disease control.We performed a retrospective study 125 patients diagnosed with EGFRm+ NSCLC treated afatinib at tertiary Asian center, exploring clinicopathological...
Abstract Context The interleukin-13 receptor alpha2 (IL13RA2), which is known to be overexpressed in glioblastoma multiforme, plays a role various cellular processes such as cell migration that may contribute tumor progression. Studies have attributed IL13RA2 invasion and metastasis cancers of the ovary, breast, pancreas, but pathological thyroid cancer still unclear. Objective This study aims evaluate expression carcinomas examine progression papillary carcinoma (PTC). Methods...
Selinexor is a selective inhibitor of nuclear export with anti-cancer properties. We performed phase I study to determine the safety and maximum tolerated dose selinexor when combined high-dose dexamethasone, ifosfamide, carboplatin etoposide (DICE) in relapsed/refractory T-cell lymphoma (TCL) natural-killer/T-cell (NKTL). Patients TCL NKTL were treated standard ICE, dexamethasone 20 mg on days 3 7, escalating doses oral 3, 5 7 3+3 design. Dose levels (DL) 1, 2 40, 60 80 mg, respectively....
Abstract Background The efficacy of a combination nimotuzumab, humanized monoclonal antibody to the epidermal growth factor receptor, with chemoradiation in locally advanced head and neck squamous cell carcinoma (HNSCC) was evaluated phase II study. Methods Patients stage III/IV HNSCC received 3‐weekly cisplatin 100 mg/m 2 for three cycles weekly nimotuzumab 200 mg 8 weeks concurrently radiotherapy. Primary endpoint best overall response (BOR) secondary progression‐free survival (PFS)....
Aim Benefit of adjuvant imatinib therapy following curative resection in patients with intermediate-risk gastrointestinal stromal tumor (GIST) is unclear. GIST-specific exon mutations, particular 11 deletions, have been shown to be prognostic. We hypothesize that specific KIT mutations may improve risk stratification GIST, identifying a subgroup who benefit from therapy. Methods In total, 142 GIST complete clinicopathologic and mutational data two sites were included. Risk classification was...
Abstract Background Recent evidence supports hippocampal avoidance with whole brain radiotherapy (HA-WBRT) as the recommended treatment option in patients good prognosis and multiple metastases this results better neurocognitive preservation compared to radiotherapy. However, there is often poor tumour control technique due low doses given. Stereotactic Radiosurgery (SRS), a form of focused which given who have limited number metastases, delivers higher radiation dose resulting target lesion...