A5015233832- Gastrointestinal motility and disorders
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- Immunotherapy and Immune Responses
- Religion, Spirituality, and Psychology
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Palliative Care and End-of-Life Issues
- Microscopic Colitis
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Radiation Therapy and Dosimetry
- Nanoplatforms for cancer theranostics
- Helicobacter pylori-related gastroenterology studies
- Stress Responses and Cortisol
- Frailty in Older Adults
- Gastrointestinal disorders and treatments
- Grief, Bereavement, and Mental Health
- Glutathione Transferases and Polymorphisms
- Neurotransmitter Receptor Influence on Behavior
- Photodynamic Therapy Research Studies
- Ferroptosis and cancer prognosis
National Cancer Centre Singapore
2005-2025
Sherwood Forest Hospitals NHS Foundation Trust
2023-2024
Kings Mill Hospital
2024
Nottingham University Hospitals NHS Trust
2021-2024
Lincoln County Hospital
2018-2022
NIHR Nottingham Digestive Diseases Biomedical Research Unit
2021-2022
University of Nottingham
2021-2022
Nottingham Biomedical Research Centre
2021-2022
University of Lincoln
2021
Agroécologie
2019
Upconversion nanoparticles (UCNPs) are the preferred choice for deep-tissue photoactivation, owing to their unique capability of converting deep tissue-penetrating near-infrared light UV/visible photoactivation. Programmed photoactivation multiple molecules is critical controlling many biological processes. However, syntheses such UCNPs require epitaxial growth shells on core nanocrystals and highly complex/time-consuming. To overcome this bottleneck, we have modularly assembled two distinct...
Radiotherapy is the primary treatment modality for most head and neck cancers (HNCs). Despite addition of chemotherapy to radiotherapy enhance its tumoricidal effects, almost a third HNC patients suffer from locoregional relapses. Salvage therapy options such recurrences are limited often suboptimal, partly owing divergent tumor microenvironmental factors underpinning radioresistance. In this study, we utilized combinatorial functionomics approach, Quadratic Phenotypic Optimization Platform...
Bacteria often colonize the lower respiratory tract of patients with bronchiectasis. Although role these bacteria in pathogenesis disease is uncertain, their accurate identification important for epidemiologic and treatment purposes. Therefore, aims this study were: (1) to identify bronchiectasis without cystic fibrosis using protected catheter brush (PCB) order avoid oropharyngeal contamination, (2) compare results bronchoalveolar lavage (BAL) PCB. Quantitative culture was performed on PCB...
Background Endoscopy within 24 h of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time endoscopy outcomes and identify factors affecting delayed (>24 admission). Methods This prospective multicentre enrolled patients admitted with AUGIB who underwent inpatient between November December 2017. Analyses were performed associated endoscopy, compare patient outcomes, including length stay mortality rates, early groups....
Despite numerous advances in cancer radiotherapy, tumor radioresistance remain one of the major challenges limiting treatment efficacy radiotherapy. Conventional strategies to overcome involve understanding underpinning molecular mechanisms, and subsequently using combinatorial involving radiation targeted drug combinations against these radioresistant tumors. These exploit target fingerprint vulnerability clones achieve improved eradication. However, conventional drug-screening approaches...
Hepatocellular carcinoma (HCC) is the fifth most common and third deadliest primary neoplasm. Since HCC a particularly vascular solid tumor, we determined antitumor antiangiogenic activities of sunitinib malate, potent inhibitor two receptors involved in angiogenesis – endothelial growth factor receptor (VEGFR) plateletderived (PDGFR). In present study, reported that treatment HepG2 SK-Hep-1 cells with led to inhibition apoptosis dose-dependent fashion. Sunitinib inhibited phosphorylation...
75Selenium taurocholic acid (SeHCAT) scanning diagnoses bile malabsorption/bile diarrhoea (BAM/BAD) and defines optimal treatment. Approximately 2% of the population have BAM/BAD.To evaluate cost delayed diagnosis BAM/BAD.Patients' notes who underwent SeHCAT in three hospitals over a 1-year period were reviewed retrospectively. Scan results treatment response recorded. Package-of-care costs calculated using costing tools from National Institute for Health Care Excellence United Lincolnshire...
Epidermal growth factor receptor (EGFR) overexpression is characteristic in head and neck cancers associated with tumour regrowth following photodynamic therapy (PDT).We investigated vandetanib, which selectively blocks EGFR vascular endothelial receptor-2 (VEGFR-2), to enhance the efficacy of PDT.We assessed vitro therapeutic of: 1) vandetanib; 2) PDT photosensitizer Chlorin e6 (Fotolon®); 3) combined + vadetanib treatment CAL-27 oral squamous cell carcinoma (OSCC) line by viability, γH2AX...
Introduction: Secondary malignancy of the thyroid gland is uncommon, but it a problem requiring ongoing recognition. As more common than primary malignancy, metastatic disease involving should be actively excluded in patient with enlarging or abnormal and previously known tumour. Clinical Picture: We report 2 cases colon carcinoma metastasis to that mimicked anaplastic carcinoma. In both cases, airway compromise was evident. Treatment Outcome: Emergency tracheostomy necessary first case...
Abstract Rodent defense behavior assays have been widely used as preclinical models of anxiety to study possibly therapeutic anxiety-reducing interventions. However, some proposed anxiety-modulating factors—genes, drugs and stressors—have had discordant effects across different studies. To reconcile the effect sizes purported factors, we conducted systematic review meta-analyses literature on ten anxiety-linked interventions, examined in elevated plus maze, open field light-dark box assays....
9093 Background: Handgrip strength has been shown to predict all cause mortality in several studies. The objective of our study was assess the prognostic value handgrip an Asian geriatric oncology population and its integration into comprehensive assessment (CGA). Methods: A prospective analysis CGA data including done on 249 newly diagnosed patients aged 70 years above who attended clinic at National Cancer Centre Singapore. Univariate multivariate analyses were using Cox proportional...
e15538 Background: Sorafenib has been shown to significantly prolong survival in patients with nonresectable hepatocellular carcinoma (HCC) without however significant tumour regression. The addition of radio-ablative therapy could confer additional benefit. This phase I trial was carried out ascertain the toxicities and safety this combination designed as a prelude II trial. Methods: Eligible were administered SIR-sphere (max dose 3 GBq) subsequently given (400mg bd) either 14 days (Cohort...
PurposeImproved antitumor responses have been observed in patients after combination radiation therapy (RT) and immune checkpoint blockade (ICB). Whether these clinical are linked to the host systemic system has not elucidated.Methods MaterialsIn this single-institution prospective observational study, peripheral blood was longitudinally collected from 10 with metastatic disease who had responded anti-PD-1/anti-PD-L1 ICB received RT (8-50 Gy 1-5 fractions) upon progression at following...
Since its translation into Chinese, the Functional Living Index for Cancer (FLIC) has not been widely received due to some of difficulties. We modified visual analogue scale (VAS) an ordered categorical and changed wording in instrument. This study examined measurement properties FLIC.The version FLIC Assessment Therapy (FACT-G Chinese 4) were filled by 140 patients recruited from National Centre Singapore. The patients' scores compared with their clinical characteristics establish...
The aim of this study was to assess toxicity and response in the sequential administration gemcitabine followed by cisplatin unresectable or metastatic non-small cell lung cancer.Twenty-three patients were enrolled study. Gemcitabine given at 1,250 mg/m2 on days 1 8, for four 21-day cycles.There 4 with partial responses. 5 stable disease 10 progressive disease, giving a rate 21%. median time progression 3.3 months. overall survival 14.6 Toxicities graded 3 included anaemia (13.0%),...
9504 Background: Performance status (PS) is the main clinical parameter used by most oncologists to assess ability of elderly cancer patients tolerate chemotherapy and estimate prognosis. The results comprehensive geriatric assessment (CGA) for were analyzed investigate impact each CGA functional, physical, cognitive, affective domain on overall survival in relation performance status. Methods: was 233 consecutive aged 70 above. tools included Katz index daily activities independence (ADL),...
137 Background: Resistance to RT remains a clinical challenge, given our limited understanding of the molecular pathways underpinning radioresistance. Here, we investigated for mechanisms linked RR using paired experimental and clinico-molecular HNC PCa datasets discovery validation novel that may be enriched in cancers. Methods: For data, generated (FaDu, HK1) (22Rv1, DU145) cell lines following high-dose X-irradiation (90 Gy 45 fr). Genotypic characterization wildtype (WT) cells was...
Abstract Radiotherapy is an integral modality in treating human cancers, but radioresistance remains a clinical challenge due to the involvement of multiple intrinsic cellular and extrinsic tumour microenvironment factors that govern radiosensitivity. To study are associated with cancer radioresistance, we established 4 radioresistant prostate (22Rv1 DU145) head neck (FaDu HK1) models by irradiating their wild-type parentals 90 Gy, mimicking fractionated radiotherapy schema often using...
Introduction: Data on combined modality treatment for locally advanced squamous cell carcinoma of the oesophagus involving Asian patients are limited. Materials and Methods: A retrospective study 56 consecutive with this condition treated concurrent chemoradiotherapy followed by surgery in a single tertiary institution Singapore was performed. Results: The median overall survival entire cohort 14.1 months [95% confidence interval (CI); range, 8.6 to 19.6 months]. In who underwent successful...